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ICCB-19 hydrochloride is a research-grade small molecule that inhibits TRADD-mediated signaling and indirectly inhibits RIPK1 kinase activity. It has been reported to induce autophagy, modulate TNF-induced inflammatory responses, and affect RIPK1-dependent apoptosis in cellular and animal models.
Targets TRADD and indirectly inhibits RIPK1 kinase activity.
Binds TRADD N-terminal domain to disrupt protein interactions.
Promotes autophagy via K63-linked ubiquitination of Beclin-1.
Reduces TNF-induced inflammatory gene expression in cell and animal studies.
Provided as a hydrochloride salt with reported high purity.
Available as solid and DMSO solution aliquots for research use.
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