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Methylamino-PEG1-Boc, also known as Methylamino-PEG1-t-butyl ester, is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands joined by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets the protein of interest. This mechanism allows PROTACs to harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
PEG-based PROTAC linker
Utilized in the synthesis of PROTACs
PROTACs consist of two distinct ligands joined by a linker
PROTACs harness the intracellular ubiquitin-proteasome system
Selectively degrades target proteins
Intended for research use only
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