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Organonitrogen Compounds

Organic compounds that contain one or more nitrogen atoms.
Hydrazines and derivatives (4)
Tertiary amines (2)
Nitrogen mustard compounds (1)

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1

Medchemexpress LLC VIT-2763 | 2095668-10-1 | 99.9% | 408.43 | 50 MG
SDP

VIT-2763 is an oral ferroportin inhibitor designed to inhibit hepcidin binding to ferroportin and block iron efflux. It holds potential for treating β-thalassemia by addressing iron regulation. This compound has demonstrated significant biological activity both in vitro and in vivo.

  • Reduces fluorescence polarization signal by displacing TMR-hepcidin from ferroportin.
  • Induces BLA reporter gene activity, increasing intracellular iron concentrations by blocking iron export.
  • Triggers ubiquitination and degradation of ferroportin.
  • Corrects anemia and improves red blood cell parameters in relevant animal models.
  • Decreases the percentage of ROS-positive red blood cells and extends their lifespan.
  • Significantly decreases serum iron levels in animal studies.
  • Currently undergoing Phase 2 clinical trials for Beta-Thalassemia and Sickle Cell Disease.

ENCOMPASS_PREFERRED
2

Medchemexpress LLC Semicarbazide hydrochloride | 563-41-7 | MFCD00013009 | 98.0% | 111.53 g/mol | CH6ClN3O | 1mL
SDP

Semicarbazide hydrochloride is an orally active urea derivative Semicarbazide hydrochloride binds to copper or iron in cells Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO) Semicarbazide hydrochloride damages cartilage blood vessels ovaries testicles and thyroid follicles[1][2][3][4][5][6][7][8][9]

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Semicarbazide hydrochloride | 563-41-7 | MFCD00013009 | 98.0% | 111.53 | CH6ClN3O | 100g
SDP

Semicarbazide hydrochloride is an orally active urea derivative Semicarbazide hydrochloride binds to copper or iron in cells Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO) Semicarbazide hydrochloride damages cartilage blood vessels ovaries testicles and thyroid follicles[1][2][3][4][5][6][7][8][9]

ENCOMPASS_PREFERRED
4

Medchemexpress LLC Semicarbazide hydrochloride | 563-41-7 | MFCD00013009 | 98.0% | 111.53 g/mol | CH6ClN3O | 10g
SDP

Semicarbazide hydrochloride is an orally active urea derivative Semicarbazide hydrochloride binds to copper or iron in cells Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO) Semicarbazide hydrochloride damages cartilage blood vessels ovaries testicles and thyroid follicles[1][2][3][4][5][6][7][8][9]

ENCOMPASS_PREFERRED
5

Medchemexpress LLC Semicarbazide (hydrochloride) | 563-41-7 | MFCD00013009 | 98.0% | 111.53 | CH6ClN3O | 50g
SDP

Semicarbazide hydrochloride is an orally active urea derivative Semicarbazide hydrochloride binds to copper or iron in cells Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO) Semicarbazide hydrochloride damages cartilage blood vessels ovaries testicles and thyroid follicles[1][2][3][4][5][6][7][8][9]

ENCOMPASS_PREFERRED
6

4-Amino-2-dimethylamino-6-hydroxy-5-nitrosopyrimidine 98.0+%, TCI America™

CAS: 70700-44-6 Molecular Formula: C6H9N5O2 Molecular Weight (g/mol): 183.171 MDL Number: MFCD00059767 InChI Key: WQJLLOCUCJRMMW-UHFFFAOYSA-N Synonym: 6-Amino-2-dimethylamino-5-nitroso-4-pyrimidinol, 4-Hydroxy-2-dimethylamino-5-nitroso-6-aminopyrimidine PubChem CID: 319506 IUPAC Name: 6-amino-2-(dimethylamino)-5-nitroso-1H-pyrimidin-4-one SMILES: CN(C)C1=NC(=O)C(=C(N1)N)N=O

PubChem CID 319506
CAS 70700-44-6
Molecular Weight (g/mol) 183.171
MDL Number MFCD00059767
SMILES CN(C)C1=NC(=O)C(=C(N1)N)N=O
Synonym 6-Amino-2-dimethylamino-5-nitroso-4-pyrimidinol, 4-Hydroxy-2-dimethylamino-5-nitroso-6-aminopyrimidine
IUPAC Name 6-amino-2-(dimethylamino)-5-nitroso-1H-pyrimidin-4-one
InChI Key WQJLLOCUCJRMMW-UHFFFAOYSA-N
Molecular Formula C6H9N5O2