Organooxygen compounds
Medchemexpress LLC Simufilam hydrochloride (PTI-125 hydrochloride) | 2480226-07-9 | 99.9% | 295.81 | 25 MG
Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. It restores NMDAR signaling and Arc expression. It inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ42-induced neuroinflammation, and tau protein hyperphosphorylation. This product can be used for research related to Alzheimer's disease.
- Reduces FLNA-α7nAChR/TLR4 associations and dissociates Aβ42-α7nAChR complexes.
- Restores α7nAChR/NMDAR/IR function and NMDAR signaling and arc expression in human AD brain slices.
- Decreases tau phosphorylation, Aβ42 aggregates, and inflammatory cytokines in mouse models.
- Improves NMDAR/IR function, synaptic plasticity, spatial/working memory, and nesting behavior in 3xTg AD mice.
Medchemexpress LLC Elacridar hydrochloride | 143851-98-3 | 99.8% | C34H34ClN3O5 | 5 MG
Elacridar hydrochloride (GF120918A) is an orally active dual-inhibitor of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). This compound is used for research to examine the influence of efflux transporters on agent distribution to the brain and for cancer research.
- Orally active P-glycoprotein (P-gp) inhibitor
- Orally active breast cancer resistance protein (BCRP) inhibitor
- Used to examine the influence of efflux transporters on agent distribution to the brain
- Applicable for cancer research
- Inhibits cell viability of 786-O cells in vitro
- Affects P-glycoprotein and ABCG2 protein expression levels in MCF-7 and 786-O cell lines
- Increases ⁹⁹mTc-MIBI intracellular accumulation in MCF-7 and 786-O cell lines
Aobchem 1-(Benzofuran-2-yl)-2-methylpropan-1-one | ≥95% | CAS 91420-41-6 | C12H12O2 | 250mg
1-(Benzofuran-2-yl)-2-methylpropan-1-one | ≥95% | CAS 91420-41-6 | C12H12O2 | 250mg
Aobchem 2-(Benzofuran-2-yl)propan-2-ol | ≥95% | CAS 59302-96-4 | C11H12O2 | 250mg
2-(Benzofuran-2-yl)propan-2-ol | ≥95% | CAS 59302-96-4 | C11H12O2 | 250mg
Aobchem 2-Methoxy-4-pyridinemethanol | 97% | CAS 123148-66-3 | C7H9NO2 | 500g
2-Methoxy-4-pyridinemethanol | 97% | CAS 123148-66-3 | C7H9NO2 | 500g
Aobchem Ethyl benzofuran-3-carboxylate | ≥97% | CAS 194278-43-8 | C11H10O3 | 5g
Ethyl benzofuran-3-carboxylate | ≥97% | CAS 194278-43-8 | C11H10O3 | 5g
Aobchem 1-(2 3 4-Trifluorophenyl)ethanol | ≥97% | CAS 1340441-08-8 | C8H7F3O | 5g
1-(2 3 4-Trifluorophenyl)ethanol | ≥97% | CAS 1340441-08-8 | C8H7F3O | 5g
Aobchem Phenyl(4-propylphenyl)methanol | ≥95% | CAS 51166-13-3 | C16H18O | 5g
Phenyl(4-propylphenyl)methanol | ≥95% | CAS 51166-13-3 | C16H18O | 5g
Aobchem Phenyl(4-propylphenyl)methanol | ≥95% | CAS 51166-13-3 | C16H18O | 500mg
Phenyl(4-propylphenyl)methanol | ≥95% | CAS 51166-13-3 | C16H18O | 500mg
Aobchem 2-(Benzofuran-2-yl)propan-2-ol | ≥95% | CAS 59302-96-4 | C11H12O2 | 1g
2-(Benzofuran-2-yl)propan-2-ol | ≥95% | CAS 59302-96-4 | C11H12O2 | 1g
![Aobchem 1-[4-(4-Pyridinyl)phenyl]ethanone | ≥95% | CAS 70581-00-9 | C13H11NO | 250mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000974451.png-250.jpg)
Aobchem 1-[4-(4-Pyridinyl)phenyl]ethanone | ≥95% | CAS 70581-00-9 | C13H11NO | 250mg
1-[4-(4-Pyridinyl)phenyl]ethanone | ≥95% | CAS 70581-00-9 | C13H11NO | 250mg