Organooxygen compounds
Medchemexpress LLC VU0453379 hydrochloride | 98.0% | 471.03 | 25 MG
VU0453379 hydrochloride is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM.
- Highly selective
- CNS penetrant
- Positive allosteric modulator (PAM) of GLP-1R
Medchemexpress LLC Amxi-5001 hydrochloride | 98.05% | C25H21ClFN5O3 | 50 MG
AMXI-5001 hydrochloride is a potent, orally active compound that acts as a dual inhibitor of parp1/2 and microtubule polymerization. It demonstrates selective antitumor cytotoxicity across various human cancer cells, with significantly lower IC50s compared to existing clinical PARP1/2 inhibitors. AMXI-5001 hydrochloride has been shown to induce complete regression of established tumors, including large ones.
- Potent, orally active, dual parp1/2 and microtubule polymerization inhibitor.
- Exhibits selective antitumor cytotoxicity in a wide range of human cancer cells.
- Shows much lower IC50s than current clinical PARP1/2 inhibitors.
- Capable of inducing complete regression of established tumors, including exceedingly large tumors.
Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | 99.9% | 430.32 | 100 MG
Befiradol hydrochloride | 2436760-81-3 | 99.9% | 430.32 | 100 MG
Medchemexpress LLC Aplaviroc hydrochloride | 461023-63-2 | 99.9% | 614.17 | 100 MG
Aplaviroc hydrochloride is a potent CCR5 antagonist, effective against wild-type R5 HIV-1 strains with IC50 values of 0.1 to 0.4 nM. It also suppresses the infectivity and replication of HIV-1MDR variants at low concentrations. This compound binds to CCR5 with high affinity and has been shown to suppress R5 HIV-1 viremia in animal models. Aplaviroc hydrochloride has been involved in multiple clinical trials for HIV infection.
- Potent CCR5 antagonist
- Effective against wild-type R5 HIV-1 strains
- Suppresses HIV-1MDR variants
- Binds to CCR5 with high affinity
- Suppresses R5 HIV-1 viremia in animal models
- Investigated in clinical trials for HIV infection
Medchemexpress LLC Amrubicin hydrochloride | 110311-30-3 | MFCD00876391 | 98.78% | C25H26ClNO9 | 1 MG
Amrubicin hydrochloride (SM-5887) is a DNA topoisomerase II inhibitor primarily used for cancer research. It exhibits significant cytotoxic effects on various cell lines, including A549, HT-29, and K562 cells, and shows potent antitumor activities in SCLC tumors and other cancer xenograft models.
- DNA topoisomerase II inhibitor
- Used for cancer research
- Cytotoxic against A549, HT-29, and K562 cells
- Shows radio-enhancement effects on human lung adenocarcinoma A549 cells
- Antitumor activities against SCLC tumors
Medchemexpress LLC BMY-25368 hydrochloride | 86134-36-3 | 97.0% | 379.88 | 5 MG
BMY-25368 (SKF 94482) is a histamine H2 receptor antagonist that acts as a gastric acid secretion inhibitor. It competitively antagonizes gastric secretion stimulated by histamine, Pentagastrin, Bethanechol, and food. This product is for research use only and not intended for medical applications.
- Acts as a histamine H2 receptor antagonist
- Inhibits gastric acid secretion
- Antagonizes gastric secretion stimulated by histamine, Pentagastrin, Bethanechol, and food
- Light yellow to yellow solid
- Suitable for laboratory research
Medchemexpress LLC Amiloride hydrochloride | 2016-88-8 | 99.8% | 25 MG
Amiloride hydrochloride is an analytical standard intended for research and analytical applications. It acts as an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA), and is also identified as a blocker of the polycystin-2 (PC2; TRPP2) channel. This compound is commonly used as a reference standard in qualitative, quantitative, and methodological research experiments.
- Used as an analytical standard
- Inhibits epithelial sodium channel (ENaC)
- Inhibits urokinase-type plasminogen activator receptor (uTPA)
- Blocks polycystin-2 (PC2; TRPP2) channel
- Suitable for HPLC, GC, and MS experiments
Medchemexpress LLC Slm6031434 hydrochloride | 1897379-34-8 | 99.1% | 5MG
Slm6031434 hydrochloride | 1897379-34-8 | 99.1% | 5MG
Medchemexpress LLC Vatinoxan hydrochloride | 130466-38-5 | 99.79% | 454.97 | 25 MG
Vatinoxan hydrochloride is a peripheral α2 adrenergic receptor antagonist. It has been shown to increase cardiac index and tissue oxygen delivery without deleterious adverse effects when administered alone. Furthermore, it attenuates or prevents dexmedetomidine's systemic hemodynamic effects in a dose-dependent manner and shortens the sedative effect without altering its quality. This product is intended for research use only.
- Peripheral α2 adrenergic receptor antagonist.
- Increases cardiac index and tissue oxygen delivery.
- Attenuates or prevents dexmedetomidine's systemic hemodynamic effects.
- Shortens sedative effect without altering its quality.
- Intended for research use only.
Medchemexpress LLC Voreloxin Hydrochloride | 175519-16-1 | 99.58% | 437.90 | 50 MG
Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
- Inhibits topoisomerase II activity.
- Induces site-selective DNA DSB.
- Causes G2 arrest.
- Leads to apoptosis.
- Shows potent cytotoxic activity in AML cell lines.
- Exhibits additive or synergistic activity with cytarabine in acute leukemia cell lines.
- Reduces bone marrow cellularity in mice.
- Causes reversible decrease in myeloid and lymphoid cells in vivo.
Medchemexpress LLC AR-C102222 hydrochloride | 1781934-50-6 | 99.8% | 50 MG
AR-C102222 hydrochloride is a selective inducible nitric oxide synthase (iNOS) inhibitor (IC50 = 37 nM) provided as the hydrochloride salt for research use. It exhibits reported antinociceptive and anti-inflammatory activity and is supplied as a high-purity solid suitable for in vitro and in vivo studies.
- Purity 99.83%.
- Molecular weight 418.83 g/mol.
- Chemical formula C19H17ClF2N6O.
- Soluble in DMSO (100 mg/mL); formulatable for in vivo dosing (≥5 mg/mL in recommended vehicles).
- Storage: 4°C sealed; in solvent store at -80°C (6 months) or -20°C (1 month).
- Available as solid in multiple sizes, including 50 mg.
Medchemexpress LLC Ro 41-1049 hydrochloride | 127917-66-2 | MFCD00900596 | 100.0% | 301.77 g·mol⁻¹ | C12H13ClFN3OS | 1 ML
Ro 41-1049 hydrochloride is a reversible, selective monoamine oxidase A (MAO-A) inhibitor supplied for research use. It is available as a solid and as a pre-made 10 mM solution in DMSO (1 mL), and is provided with a high reported purity to support reproducible in vitro experiments.
- Reversible, selective MAO-A inhibition suitable for biochemical assays.
- Supplied as solid or pre-made 10 mM solution in DMSO (1 mL) for convenience.
- High reported purity to reduce confounding impurities.
- Characterized by CAS number 127917-66-2 and known molecular weight for accurate dosing.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Zoniporide hydrochloride hydrate | 863406-85-3 | 99.4% | 374.82 g/mol | C17H19ClN6O2 | 25 MG
Zoniporide hydrochloride hydrate is the hydrochloride hydrate salt of zoniporide, a potent and selective inhibitor of the sodium-hydrogen exchanger isoform 1 (NHE-1) used for research applications. It is provided as a high-purity solid suitable for in vitro and ex vivo studies of NHE-1 function and related cardiovascular and platelet biology.
- Potent and selective NHE-1 inhibition (human IC50 ~14 nM).
- Inhibits ex vivo NHE-1-dependent platelet swelling (IC50 ~59 nM).
- High purity (>99% by HPLC).
- Available as the hydrochloride hydrate salt for improved handling and stability.
- Molecular weight 374.82 g/mol; molecular formula C17H19ClN6O2.
- Supplied in small research quantities, e.g., 25 MG.
Medchemexpress LLC Oxyfedrine hydrochloride | 16777-42-7 | 99.9% | 349.85 | C19H24ClNO3 | 25 MG
Oxyfedrine hydrochloride is the hydrochloride salt of oxyfedrine, an orally active beta-adrenoreceptor agonist and vasodilator used in pharmacological research. Supplied as a solid research-grade powder, it includes batch analytical data to support experimental use and handling.
- High purity powder (~99.9%).
- Acts as a beta-adrenoreceptor agonist and vasodilator for pharmacology studies.
- Solid form with defined molecular weight and formula for dosing calculations.
- Stable when stored sealed, protected from moisture and light.
- Provided with batch-specific analytical documents (COA, HNMR, LCMS).
Medchemexpress LLC Fadrozole hydrochloride | 102676-31-3 | 99.9% | C14H14ClN3 | 25 MG
Fadrozole hydrochloride (CGS 16949A) is a potent, selective, and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. It inhibits estrogen production in hamster ovarian slices and has various in vivo effects, including the prevention of certain tumors and reduction of parasite burden.
- Potent, selective, and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM.
- Inhibits estrogen production with an IC50 of 0.03 μM.
- Inhibits progesterone production with an IC50 of 120 μM.
- Inhibits aromatase-mediated uterine hypertrophy in immature female rats with an oral ED50 of 0.03 mg/kg.
- Prevents development of benign and malignant spontaneous mammary neoplasms.
- Slows spontaneous development of pituitary pars distalis adenomas.
- Reduces incidence of spontaneous hepatocellular tumors.
- Reduces parasite burden in male and female mice by 70%.