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Azide-PEG8-alcohol is a PEG-based PROTAC linker that functions as a click chemistry reagent with an Azide group. It participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This molecule is used in the synthesis of PROTACs, which harness the ubiquitin-proteasome system for selective protein degradation.
Peg-based PROTAC linker
Utilized in PROTAC synthesis
Click chemistry reagent
Features an Azide group
Enables CuAAc reactions with alkyne groups
Enables SPAAC reactions with DBCO or BCN groups
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