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Chemical. CAS 586976-24-1. Formula C31H43ClF3NO2. MW 554.1. Potent activator of p300 HAT histone acetyltransferase activity, which has an important role in regulation of gene expression. Does not show PCAF p300/CBP-associated factor HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.
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Chemical. CAS 1143863-69-7. Formula C15H11FO2. MW 242.2. Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90beta heterocomplexes, consequently blocking its function and inhibiting cancer cell motility. Does not bind to Cdc37 or HSP90beta alone. Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer. Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
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Chemical. CAS 872573-93-8. Formula C18H13N3OS2. MW 351.5. Selective CDK 1 inhibitor Cdk1/B1 and Cdk1/A. Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M . Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards.
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Sonidegib metabolite M48 is the primary circulating metabolite of sonidegib, provided as a research-grade chemical for laboratory studies. The compound has formula C15H11F3O3, molecular weight 296.24 g·mol⁻¹, and is supplied with documented purity and storage recommendations for research use only.
Research use only; not for human or clinical use.
High reported purity: 98.0%.
White to off-white solid suitable for analytical and in vitro studies.
Available in small research quantities for assay development and metabolic studies.
Stable at room temperature for up to 3 years under recommended storage conditions.
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An isothiocyanate that potently induces chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression; at 15 μM, inhibits class I and II HDAC activity and suppresses tumor growth selectively in cancerous prostate epithelial cells without affecting normal cells
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S-(2,4-dinitrophenyl)glutathione is a glutathione derivative in which the cysteine thiol is modified with a 2,4-dinitrophenyl group. It is used as a substrate and inhibitor in biochemical studies of glutathione-related enzymes and for enzymatic assays, supplied as a solid with analytical documentation for research use.
High purity (99.89%).
Molecular weight 473.41 g/mol.
Molecular formula C16H19N5O10S.
Available sizes: 1 mg, 5 mg, 10 mg (larger sizes by request).
Storage: sealed powder at -80°C (long term) or -20°C (short term).
Datasheet, SDS, and COA available for quality and handling information.
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Sulfanilamide is a competitive inhibitor targeting bacterial dihydropteroate synthetase (DHPS) an enzyme essential in microbial folate biosynthesis pathway By inhibiting DHPS the compound limits synthesis of dihydrofolate a precursor crucial for bacterial DNA replication and proliferation In enzymatic assays evaluating inhibition potency Sulfanilamide demonstrates an IC50 value of approximately 320 M Due to its defined mode of action Sulfanilamide is extensively utilized in microbiology and pharmacology research particularly for investigating bacterial metabolic pathways resistance mechanisms and screening potential antibacterial agents
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Hydroxyethyl disulfide is a small-molecule disulfide reagent used in biochemical research and enzymology. It has been reported to block the inhibitory effect of showdomycin on methotrexate-resistant thymidylate synthase. Prior to use, consult the safety data sheet and certificate of analysis for handling and quality information.
High purity suitable for research use.
Single CAS-registered chemical for unambiguous identification.
Simple molecular composition with formula C4H10O2S2.
Available in multiple sizes, including a 25 g package.
Safety and quality documentation (SDS, COA, datasheet) available.
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