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S-Isopropylisothiourea hydrobromide is a small-molecule inhibitor targeting nitric oxide synthase (NOS) It is designed to inhibit NOS activity thereby reducing nitric oxide (NO) production and modulating NO-mediated biological processes S-Isopropylisothiourea hydrobromide exerts its biological activity primarily through selective NOS inhibition Based on these pharmacological properties S-Isopropylisothiourea hydrobromide holds research potential in investigating NO-related processes particularly in pathophysiological contexts such as hemorrhagic shock
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IPTU is a potent inhibitor of NOS in vitro but may lack good in vivo efficacy due to poor cellular penetration. The Ki values are 9.8, 22, and 37 nM using purified human iNOS, eNOS, and nNOS, respectively.{1292}
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