Phenylpropanoids and polyketides
Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | 99.9% | 822.03 | 10 MM 1 ML
Tacrolimus monohydrate is a macrocyclic lactone that binds to FKBP to form a complex, inhibiting calcineurin phosphatase. This action suppresses T-lymphocyte signal transduction and IL-2 transcription, resulting in immunosuppressive properties. It is intended for research use only.
- Inhibits T-lymphocyte signal transduction
- Inhibits IL-2 transcription
- Immunosuppressive properties
- Potentiates glucocorticoid and progesterone actions
- May enhance TGFβ-1 gene expression
- Inhibits T cell proliferation
Medchemexpress LLC Hydrocinnamic acid | 501-52-0 | MFCD00002771 | 99.9% | 150.18 g·mol⁻¹ | C9H10O2 | 5g
Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities
Medchemexpress LLC Hydrocinnamic acid-d9 (3-phenylpropionic acid-d9) | 93131-15-8 | MFCD01075426 | 99.7% | 159.23 | C9HD9O2 | 50mg
Hydrocinnamic acid-d9 is the deuterium labeled Hydrocinnamic acid[1] Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activitie[2]s
Sigma Aldrich Fine Chemicals Biosciences Paraffin oil puriss., meets analytical specification of Ph. Eur., BP, viscous liquid | 8012-95-1 | MFCD00131611 | 2.5L
Paraffin oil puriss., meets analytical specification of Ph. Eur., BP, viscous liquid | 8012-95-1 | MFCD00131611 | 2.5L
Medchemexpress LLC Naringenin trimethyl ether | 38302-15-7 | 1 MG
Naringenin trimethyl ether is a constituent of twigs and leaves of Aglaia duperreana. It is known for its significant molluscicidal activity, demonstrating an LC50 of 3.9 μg/mL for P. canaliculata. This compound is intended for research use only.
- Constituent of twigs and leaves of Aglaia duperreana
- Exhibits significant molluscicidal activity
- LC50 of 3.9 μg/mL for P. canaliculata
Apexbio Technology LLC Doxorubicin (Adriamycin) HCl 25316-40-9 10mM (in 1mL DMSO)
Doxorubicin hydrochloride an anthracycline antibiotic derivative exhibits cytotoxic activity and is widely utilized as an anticancer chemotherapeutic agent Its mechanism involves intercalating into DNA double-strands inhibiting DNA topoisomerase II activity and consequently interrupting replication processes causing DNA damage and altered chromatin structure by histone displacement In biomedical research settings doxorubicin hydrochloride is employed in vitro and in animal models to study therapeutic strategies against hematologic malignancies solid tumors and sarcomas Reported IC50 values vary with cell type and assay conditions typically ranging between approximately 0 1 M to 2 M in various tumor-derived cell models
Medchemexpress LLC Avobenzone | 70356-09-1 | 98.0% | 100 MG
Avobenzone is a dibenzoylmethane compound widely used as a UVA filter in sunscreens for skin photoprotection. It is also an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist.
- Significantly promotes adipogenesis in hBM-MSCs
- Significantly up-regulates mRNA levels of PPARγ during adipogenesis in hBM-MSCs
- Inhibits proliferative activities of human trophoblast cells and induces apoptosis in HTR8/SVneo cells
- Shows weak ERα agonism and weak AR antagonism
Medchemexpress LLC Luteolin 5-O-glucoside | 20344-46-1 | 448.38 | 1 MG
Luteolin 5-O-glucoside is a major flavonoid extracted from *Cirsium maackii*. It exhibits anti-inflammatory properties by inhibiting LPS-induced NO production and t-BHP-induced ROS generation. This compound also suppresses the expression of iNOS and COX-2 in macrophages, making it suitable for various research applications focusing on inflammation pathways.
- Inhibits LPS-induced NO production.
- Suppresses t-BHP-induced ROS generation.
- Reduces expression of iNOS and COX-2 in macrophages.
- Derived from natural plant sources.
Medchemexpress LLC Apigenin-7-O-sulfate potassium | 120562-19-8 | 99.9% | 388.39 | C15H9KO8S | 1mg
Apigenin-7-O-sulfate is a major flavonoid which is found to be a distinctive feature of plants from the Bay of Cadiz and can be extracted from these plants[1]
Cayman Chemical Luteolin Inhibitors
A common dietary phenolic flavone; inhibits soybean and reticulocyte 15-lipoxygenases (IC50 = 0.6 µM); inhibits the release of TNFα from neutrophils; inhibits matrix metalloproteinases
Cayman Chemical EpIcatechIn 25mg
A polyphenol flavonoid with diverse biological activities; scavenges DPPH radicals in a cell-free assay at 5 µM; inhibits COX-1 (IC50 = 3.2 μM); acts synergistically with epigallocatechin gallate to induce apoptosis in, and reduce the proliferation of, PC-9 cells at 200 µM; reduces LPS-induced increases in plasma creatinine and urea levels in a rat model of renal inflammation at 80 mg/kg