Macrolide lactams
Macrolide lactams
Ascomycin, 95%, Thermo Scientific Chemicals
CAS: 104987-12-4 Molecular Formula: C43H69NO12 Molecular Weight (g/mol): 792.02 MDL Number: MFCD06198665 InChI Key: ZDQSOHOQTUFQEM-NURRSENYSA-N Synonym: ascomycin,immunomycin,unii-auf4u5nsjk,ascomycin fk520,auf4u5nsjk,chembl8597,15,19-epoxy-3h-pyrido 2,1-c 1,4 oxaazacyclotricosine-1,7,20,21 4h,23h-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-2-4-hydroxy-3-methoxycyclohexyl-1-methylethenyl-14,16-dimethoxy-4,10,12,18-tetram,ascomycin from streptomyces hygroscopicus var. ascomyceticus,15,19-epoxy-3h-pyrido 2,1-c 1,4 oxaazacyclotricosine-1,7,20,21 4h,23h-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-8-ethyl-3-2-4-hydroxy-3-methoxycyclohexyl-1-methylethenyl-14,16-dimethoxy-4,10,12,18-tetramethyl-, 3s-3r* e 1s*,3s*,4s* ,4s*,19s*,26ar*,ascomycin fk 520, fr 900520, imm PubChem CID: 5282071 ChEBI: CHEBI:29582 SMILES: CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C
Tacrolimus Monohydrate 80.0+%, TCI America™
CAS: 109581-93-3 Molecular Formula: C44H71NO13 Molecular Weight (g/mol): 822.046 MDL Number: MFCD11045918 InChI Key: NWJQLQGQZSIBAF-MLAUYUEBSA-N Synonym: FK 506 PubChem CID: 5282315 ChEBI: CHEBI:61057 SMILES: CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC.O
eMolecules Ascomycin | 104987-12-4 | | 1g
Combi-Blocks | Ascomycin | 1g | 296391981 | QA-7570 | 96.000 | 104987-12-4 | | 792.020 | C43H69NO12
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AdipoGen Ascomycin high purity
Chemical. CAS 104987-12-4. Formula C43H69NO12. MW 792. Isolated from Streptomyces sp. Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin protein phosphatase 2B PP2B. Suppresses the production of T helper type 1 Th1 interferon and IL-2 and Th2 IL-4 and IL-10 cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant antiepileptic.
Sigma Aldrich Fine Chemicals Biosciences Tacrolimus monohydrate European Pharmacopoeia (EP) Reference Standard | 109581-93-3 | MFCD11045918 |
Tacrolimus monohydrate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 |
Sigma Aldrich Fine Chemicals Biosciences FK-506 monohydrate >=98% (HPLC) | 109581-93-3 | MFCD11045918 | 5MG
FK-506 monohydrate >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 | 5MG
TARGETMOL CHEMICALS INC FK-453 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. FK-453 is a potent antagonist of non-xanthine adenosine A1 receptor with diuretic and renal vasodilatory activity. purity: 99%
AdipoGen Ascomycin high purity
Chemical. CAS 104987-12-4. Formula C43H69NO12. MW 792. Isolated from Streptomyces sp. Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin protein phosphatase 2B PP2B. Suppresses the production of T helper type 1 Th1 interferon and IL-2 and Th2 IL-4 and IL-10 cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant antiepileptic.
AdipoGen FK-506 Tacrolimus
Chemical. CAS 109581-93-3. Formula C44H69NO12 . H2O. MW 804.0 . 18.0. Isolated from Streptomyces FCZ0311. Potent immunosuppressant as cyclosporin A and rapamycin. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 IL-2. Forms a complex with FK-506 binding protein 12 FKBP12. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B PP2B calcineurin, leading to disruption of T cell activation. Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases e.g. atopic dermatitis and with potential anti-rheumatic activity rheumatoid arthritis. Neuroprotective. Regulates nitric oxide neurotoxicity. Neurotransmitter. Ca2 release compound. NF-kappaB suppressor by induction of unfolded protein response UPR. Anti-cancer compound. Apoptosis inducer.
Sigma Aldrich Fine Chemicals Biosciences Tacrolimus for system suitability European Pharmacopoeia (EP) Reference Standard | 109581-93-3 | MFCD11045918 |
Tacrolimus for system suitability European Pharmacopoeia (EP) Reference Standard | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 |