Anthracyclines
Doxorubicin hydrochloride
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Daunorubicin hydrochloride
CAS: 23541-50-6 Molecular Formula: C27H30ClNO10 Molecular Weight (g/mol): 563.984 MDL Number: MFCD04974507 InChI Key: GUGHGUXZJWAIAS-QQYBVWGSSA-N Synonym: daunorubicin hydrochloride,daunorubicin hcl,daunomycin hydrochloride,daunoblastina,rubidomycin hydrochloride,daunorubicinol hydrochloride,daunoblastin,rubomycin,ondena,daunomycin chlorohydrate PubChem CID: 62770 IUPAC Name: (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride SMILES: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
Daunorubicin Hydrochloride 98.0+%, TCI America™
CAS: 23541-50-6 Molecular Formula: C27H30ClNO10 Molecular Weight (g/mol): 563.984 MDL Number: MFCD04974507 InChI Key: GUGHGUXZJWAIAS-QQYBVWGSSA-N Synonym: daunorubicin hydrochloride,daunorubicin hcl,daunomycin hydrochloride,daunoblastina,rubidomycin hydrochloride,daunorubicinol hydrochloride,daunoblastin,rubomycin,ondena,daunomycin chlorohydrate PubChem CID: 62770 IUPAC Name: (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride SMILES: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
Doxorubicin Hydrochloride 95.0+%, TCI America™
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Doxorubicin hydrochloride, MP Biomedicals™
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Selleck Chemical LLC Daunorubicin HCl S3035-50mg
Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0 02 M in a cell-free assay Daunorubicin is a topoisomerase II inhibitor that induces apoptosis Daunorubicin (RP 13057) HCl can be used to induce animal models of Kidney Disease
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 50mg
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
AdipoGen Doxorubicin hydrochloride
Chemical. CAS 25316-40-9. Formula C27H29NO11 . HCl. MW 579.98. Doxorubicin, a broad spectrum anthracycline antibiotic, inhibits DNA and RNA synthesis in mammalian cells and has been shown to be a very effective anti-tumor agent. Doxorubicin binds to nucleic acids by intercalating the DNA double helix and stabilizing topoisomerase II cleavage complexes, leading to DNA strand breaks at specific doxorubicin-induced sites and formation of reactive oxygen species ROS in cells. It also been shown to evict histones leading to chromatin damage. Doxorubicin induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein and has been shown to have immunosuppressive properties. DOX can reduce mitochondrial NADH accumulation and impair oxidative phosphorylation in heart tissues, events associated with reduced glucose uptake.
Sigma Aldrich Fine Chemicals Biosciences Daunorubicin hydrochloride >=90% (HPLC) | 23541-50-6 | MFCD04974507 | 5MG
Daunorubicin hydrochloride >=90% (HPLC) | Purity: >=90% (HPLC) | Mol Wt: 563.98 | 23541-50-6 | MFCD04974507 | 5MG
Apexbio Technology LLC Doxorubicin 23214-92-8 100mg
Doxorubicin is an anthracycline antibiotic commonly used as an anti-cancer agent targeting DNA replication machinery Its mechanism of action involves intercalation into DNA double helices and subsequent inhibition of DNA topoisomerase II impeding DNA synthesis and causing genomic instability Additionally Doxorubicin mediates chromatin remodeling by facilitating histone displacement from active chromatin contributing further to DNA damage and transcriptional dysregulation It is extensively employed in studies involving hematologic malignancies solid tumors and sarcomas frequently serving as a chemotherapeutic reference compound In biochemical assays Doxorubicin has demonstrated inhibitory effects on Topoisomerase II with an IC50 typically ranging between 1-10 M depending on assay conditions and cell lines applied
Sigma Aldrich Fine Chemicals Biosciences Cathine hydrochloride5MG
hydrochloride Cathine hydrochloride5MG
Apexbio Technology LLC BIIE 0246 246146-55-4 10mg
BIIE 0246 (CAS 246146-55-4) is a potent and selective antagonist of the neuropeptide Y Y2 receptor (Y2R) a G protein-coupled receptor involved in presynaptic inhibition within the central and peripheral nervous systems BIIE 0246 exhibits high affinity for Y2R with an IC50 of 3 3 nM in radioligand binding assays and Ki values between 8 15 nM in HEK293 cells expressing rat Y2 receptors In hippocampal slices BIIE 0246 (100 nM) reverses NPY-induced inhibition of excitatory postsynaptic potentials In vivo administration in rats attenuates PYY(3-36)-mediated suppression of food intake and increases feeding in satiated animals supporting its use in research on appetite regulation and anxiety-related behavior
TARGETMOL CHEMICALS INC Doxorubicin hydrochloride
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 uM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy. Purity 99.57%
Apexbio Technology LLC BIIE 0246 246146-55-4 1mg
BIIE 0246 (CAS 246146-55-4) is a potent and selective antagonist of the neuropeptide Y Y2 receptor (Y2R) a G protein-coupled receptor involved in presynaptic inhibition within the central and peripheral nervous systems BIIE 0246 exhibits high affinity for Y2R with an IC50 of 3 3 nM in radioligand binding assays and Ki values between 8 15 nM in HEK293 cells expressing rat Y2 receptors In hippocampal slices BIIE 0246 (100 nM) reverses NPY-induced inhibition of excitatory postsynaptic potentials In vivo administration in rats attenuates PYY(3-36)-mediated suppression of food intake and increases feeding in satiated animals supporting its use in research on appetite regulation and anxiety-related behavior