Phenylpropanoids and polyketides
Apexbio Technology LLC Dicoumarol 66-76-2 100mg
Dicoumarol (CAS 66-76-2) is a small molecule inhibitor targeting NAD(P)H quinone oxidoreductase 1 (NQO1) and pyruvate dehydrogenase kinase 1 (PDK1) exhibiting IC50 values of 0 37 M and 19 42 M respectively in vitro By inhibiting NQO1 Dicoumarol perturbs cellular redox homeostasis while its suppression of PDK1 modulates glycolytic flux and mitochondrial energy metabolism These actions make Dicoumarol a valuable tool for investigating tumor metabolism oxidative stress apoptosis and associated signaling pathways in biomedical research contexts
Medchemexpress LLC 4-Hydroxycoumarin | 1076-38-6 | MFCD00006856 | 10MM 1ML
4-Hydroxycoumarin | 1076-38-6 | MFCD00006856 | 10MM 1ML
Medchemexpress LLC 7-hydroxycoumarin-3-carboxylic acid N-succinimidyl ester | 134471-24-2 | 100 MG
7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. It functions as a blue fluorescent dye for labeling proteins and nucleic acids.
- Amine-reactive succinimidyl ester
- Blue fluorescent dye
- Used for labeling proteins
- Used for labeling nucleic acids
Chem-Impex International, Inc. Umbelliferone | 93-35-6 | MFCD00006878 | 100G
Umbelliferone, 93-35-6, MFCD00006878, 100G
Medchemexpress LLC Daphnetin (7,8-dihydroxycoumarin) | 486-35-1 | 99.8% | 178.14 | 5 MG
Daphnetin (7,8-dihydroxycoumarin) is a coumarin derivative found in plants of the Genus Daphne. It is a potent, orally active protein kinase inhibitor.
- Has IC50s of 7.67 μM, 9.33 μM, and 25.01 μM for EGFR, PKA, and PKC in vitro, respectively.
- Triggers ROS-induced cell apoptosis.
- Induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway.
- Possesses anti-inflammatory activity, inhibiting TNF-α, IL-1β, ROS, and MDA production.
- Exhibits schizontocidal activity against malaria parasites.
- Can be utilized in research for rheumatoid arthritis, cancer, and anti-malarial purposes.
Medchemexpress LLC 7-Ethoxy-4-methylcoumarin | 87-05-8 | 99.44% | 100 G
7-Ethoxy-4-methylcoumarin is a coumarin derivative that functions as a substrate probe for mammalian cytochromes P450 1A1, 2B4, and 2B6.
- Coumarin derivative
- Substrate probe
- Targets mammalian cytochromes P450 1A1, 2B4, and 2B6
TARGETMOL CHEMICALS INC Daphnetin 50MG
Also available in 1 mL, 10 mg, 25 mg, 100 mg and bulk. Please contact Fisher for quotes. Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50 7.67 uM), PKA (IC50 9.33 uM), and PKC (IC50 25.01 uM), also exhibit anti-oxidant and anti-inflammatory activities. Purity 99.82%
Medchemexpress LLC AZP-531 | 1088543-62-7 | 99.8% | 962.02 | 5 MG
AZP-531 | 1088543-62-7 | 99.8% | 962.02 | 5 MG
Medchemexpress LLC Palomid 529 | 914913-88-5 | 99.4% | C24H22O6 | 1 ML
The product is a potent inhibitor of both mTORC1 and mTORC2 complexes, affecting the PI3K/AKT/mTOR pathway. It demonstrates the ability to reduce endothelial cell proliferation and induce apoptosis in vitro, as well as exhibit antitumor activity in various cancer cell lines and mouse models. This compound interferes with the pathway through the dissociation of mTOR complex 1 and mTOR complex 2, leading to decreased phosphorylation of substrates, cell growth inhibition, and cell death.
- Potent inhibitor of mTORC1 and mTORC2 complexes.
- Inhibits VEGF-driven and bFGF-driven endothelial cell proliferation.
- Induces endothelial cell apoptosis.
- Reduces Akt activity in various cancer cell lines.
- Demonstrates antitumor activity in glioblastoma, prostate, and breast cancer models.
- Causes cell growth inhibition and death in cancer cells.
eMolecules 4-Methylesculetin | 529-84-0 | MFCD00006859 | 1g
Combi-Blocks | 4-Methylesculetin | 1g | 415500297 | QC-7742 | 95.000 | 529-84-0 | MFCD00006859 | 192.170 | C10H8O4
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Apexbio Technology LLC Palomid 529 914913-88-5 5mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
Apexbio Technology LLC 6,7-Dihydroxycoumarin 305-01-1 20mg
6 7-Dihydroxycoumarin (CAS 305-01-1) also known as esculetin is a naturally occurring coumarin derivative extracted from Aesculus hippocastanum Linn This compound exhibits notable antioxidant activity primarily by scavenging reactive oxygen species and inhibiting lipid peroxidation Additionally 6 7-dihydroxycoumarin has been studied for its modulatory effects on various cellular signaling pathways implicated in inflammation and apoptosis Its applications in biomedical research include investigations into oxidative stress inflammation and related disease models The compound is soluble in ethanol and dilute alkali and should be stored in a sealed cool and dry environment to preserve stability