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Triterpenoids

Compounds with a carbon skeleton based on six isoprene units that are derived biosynthetically from the acyclic C30 hydrocarbon, squalene. They have relatively complex cyclic structures, most being either alcohols, aldehydes or carboxylic acids.

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1

Apexbio Technology LLC 18α-Glycyrrhetinic acid 1449-05-4 10mg
SDP

18 -Glycyrrhetinic acid (CAS 1449-05-4) is a dietary-derived small molecule known to inhibit NF- B signaling while promoting proteasome activation Experimental studies have demonstrated that it enhances lifespan and exhibits anti-aggregation properties in multicellular organisms The compound also induces apoptosis in cellular models These activities highlight its potential utility in pharmacological research related to lifespan extension protein aggregation disorders and apoptosis-regulated diseases

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2

AdipoGen Forskolin,Chemical. CAS: 66428-89-5 and 66575-29-9
SDP

Forskolin, AdipoGen Life Sciences. Chemical. CAS: 66428-89-5 and 66575-29-9. Formula: C22H34O7. MW: 410.5. Isolated from Coleus forskohlii. Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels. Widely used tool to investigate cAMP as a second messenger. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator. Glucose transporter inhibitor. Platelet aggregation inhibitor. Stimulates lipolysis in fat cells. Non-competitive nicotinic acetylcholine receptors inhibitor. MAP kinase inhibitor. Upregulates mitochondrial uncoupling protein (UCP) mRNA levels in brown adipose tissue. Autophagy inhibitor. Hedgehog signaling inhibitor. Has antiglaucoma potential. Promotes neuronal differentiation of NSCs.

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3

Medchemexpress LLC Oleanolic acid 28-O-β-D-glucopyranoside | 14162-53-9 | 5 MG
SDP

Oleanolic acid 28-O-β-D-glucopyranoside is an orally active pentacyclic triterpenoid compound with anti-inflammatory effects. It inhibits inflammatory responses, enhances intestinal epithelial barrier function, and modulates gut microbiota in ulcerative colitis models. Its mechanism of action is related to the PI3K-AKT and MAPK signaling pathways and can be used in research for diseases such as colitis.

  • Orally active pentacyclic triterpenoid compound with anti-inflammatory effects
  • Inhibits inflammatory responses and modulates gut microbiota
  • Enhances intestinal epithelial barrier function
  • Targets IL-6 and COX-2 pathways
  • Increases transepithelial electrical resistance (TEER) and tight junction protein expression in Caco-2 cells
  • Reduces inflammatory cytokines (IL-6, TNF-α, COX-2, iNOS) in Caco-2 cells
  • Ameliorates ulcerative colitis in mouse models by reducing inflammation and improving colon health

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