Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
![eMolecules Formic Acid[for LC-MS] | TCI America | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 98.000 | OC=O | 25ml | 115078985](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC2396979.JPG-250.jpg)
eMolecules Formic Acid[for LC-MS] | TCI America | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 98.000 | OC=O | 25ml | 115078985
Formic Acid[for LC-MS] | TCI America | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 98.000 | OC=O | 25ml | 115078985
Sigma Aldrich Fine Chemicals Biosciences Formic acid European Pharmacopoeia (EP) Reference Standard | 64-18-6 | MFCD00003297 |
Formic acid European Pharmacopoeia (EP) Reference Standard | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 |
Sigma Aldrich Fine Chemicals Biosciences Formic acid reagent grade, >=95% | 64-18-6 | MFCD00003297 | 100ML
Formic acid reagent grade, >=95% | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 100ML
Medchemexpress LLC Ammonium formate | 540-69-2 | MFCD00013103 | 98.5% | 63.06 | CH5NO2 | 500g
Formic acid ammonium salt is an endogenous metabolite
Sigma Aldrich Fine Chemicals Biosciences Formic acid ACS reagent, >=88% | 64-18-6 | MFCD00003297 | 100ML
Formic acid ACS reagent, >=88% | Purity: >=88% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 100ML
Sigma Aldrich Fine Chemicals Biosciences FORMIC ACID 98-100%,1L
Formic acid 98-100% | CAS No: 64-18-6 | Linear Formula: HCOOH | Molecular Weight: 46.03 | 1 liter
TARGETMOL CHEMICALS INC QUILSECONAZOLE FORMIC AC 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Quilseconazole Formic acid is a selective inhibitor of fungal Cyp51 with potent activities against Cryptococcus neoformans and Cryptococcus gattii.
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 |
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 |
Medchemexpress LLC Dl-01 formic | 2964513-44-6 | 98.5% | 1144.30 | C56H73N9O15S | 5 MG
DL-01 formic is a drug-linker conjugate used in the synthesis of antibody-drug conjugates (ADCs) and related research applications. It is supplied as a high-purity solid for laboratory research use only and should be handled and stored according to the product datasheet and safety documentation.
- Drug-linker conjugate for ADC synthesis
- High purity (approximately 98.5%) solid, white to light yellow
- Molecular formula C56H73N9O15S and molecular weight 1,144.30
- CAS number 2964513-44-6
- Store at -80°C, protect from light, store under nitrogen
Medchemexpress LLC Pkiota-in-2 formic | 99.04% | 402.36 | 10 MG
PKCiota-IN-2 formic is a potent inhibitor of PKCiota (IC50 of 2.8 nM), and also inhibits PKC-α (IC50 of 71 nM) and PKC-ε (IC50 of 350 nM). This compound is for research use only.
- Molecular weight of 402.36
- Formula: C25H23N5O3
- Appearance as a solid
- Color ranges from light yellow to yellow
- Soluble in DMSO at 100 mg/mL (248.53 mM); requires ultrasonic
- Ships at room temperature in continental US
- Store at 4°C sealed, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC CCT367766 (formic) | 98.1% | 992.42 | 25 MG
CCT367766 (formic) | 98.1% | 992.42 | 25 MG
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3924754 SIGMA FORMIC ACID 98 - 100
Medchemexpress LLC MRTX-EX185 formic | 2988148-70-3 | 97.23% | C34H35FN6O4 | 1 ML
MRTX-EX185 formic is a potent KRAS (G12D) inhibitor with an IC50 of 90 nM. It binds to both GDP-loaded and active GNP states of KRAS and KRAS (G12D). This compound exhibits broad-spectrum binding properties and can be utilized for studying various RAS-driven tumors, such as pancreatic cancer.
- Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells with an IC50 of 70 nM.
- Non-toxic to non-KRAS-dependent cell lines (HEK293 cells).
- Significantly inhibits ERK phosphorylation (p-ERK) in KRAS(G12C)-driven cell lineages.
Medchemexpress LLC Zelavespib formic | 97.4% | 558.39 | 25 MG
Zelavespib formic (PU-H71 formic) is a potent Hsp90 inhibitor with an IC50 value of 51 nM for Hsp90 in MDA-MB-468 cells. It is intended for research use only.
- Potent Hsp90 inhibitor
- Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO
- Available in various solid forms (5 mg, 10 mg, 25 mg, 50 mg, 100 mg)
- Also available in solution form (10 mM * 1 mL in DMSO)
- Cited in 12 publications
- Related to various compound screening libraries and small molecules
- Clinical trials listed for Metastatic Breast Cancer, Accelerated Phase MPN, Blast Phase MPN, Metastatic Solid Tumor, Lymphoma, Myeloproliferative Neoplasms (MPN), Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF)