Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Apexbio Technology LLC FSLLRY-NH2 TFA 245329-02-6 (free base) 10mg
FSLLRY-NH2 TFA is a synthetic peptide antagonist targeting protease-activated receptor 2 (PAR-2) It is designed to block PAR-2 activation thereby inhibiting intracellular signaling cascades such as calcium mobilization and MAP kinase activation that underlie inflammatory responses nociceptive transmission and immune modulation FSLLRY-NH2 TFA exerts its biological activity primarily through competitive binding to PAR-2 preventing receptor activation and downstream signaling events Based on these pharmacological properties FSLLRY-NH2 TFA holds research potential in the study of inflammation-associated disorders and pain pathways
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus, 99, 76-05-1, MFCD00004169
Trifluoroacetic acid ReagentPlus, 99
Medchemexpress LLC CH-0793076 TFA (TP3076 TFA) | 2740278-76-4 | 98.7% | 572.53 g·mol⁻¹ | C28H27F3N4O6 | 5 MG
CH-0793076 TFA is a camptothecin-like hexacyclic analog and the active metabolite of TP300 that functions as a DNA topoisomerase I inhibitor. It is supplied as a trifluoroacetate salt for research use and has demonstrated antiproliferative activity, including activity against cells expressing BCRP.
- Inhibits DNA topoisomerase I (reported IC50 ≈ 2.3 μM).
- Active metabolite of TP300.
- Demonstrates antiproliferative activity in cellular assays.
- Provided as a trifluoroacetate salt suitable for biochemical studies.
- Molecular weight 572.53 g·mol⁻¹; chemical formula C28H27F3N4O6.
TARGETMOL CHEMICALS INC 6H05 TFA 5MG
Also available in 1mg 2mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. 6H05 TFA (6H05 trifluoroacetate) is a selective and allosteric oncogenic mutant K-Ras(G12C) inhibitor. purity: 98%
Medchemexpress LLC NH2-UAMC1110 TFA | 2990021-73-1 | 99.9% | 545.46 g·mol⁻¹ | C23H24F5N5O5 | 10 MG
NH2-UAMC1110 TFA is the trifluoroacetic acid salt of an amino-functionalized derivative of UAMC1110. It is used as a chemical intermediate for the synthesis of FAPI-QS and other FAP-targeting imaging agents and radiotracers. The compound is supplied with high purity and is intended for research and radiochemistry applications where an amino handle is required for conjugation and labeling.
- High purity (99.89%) suitable for synthetic and radiochemistry use.
- Amino-functionalized derivative for conjugation and labeling.
- Trifluoroacetic acid salt form for improved handling and solubility.
- Intended for use as an intermediate in FAP-targeting radiotracer synthesis.
- Characterized by CAS number 2990021-73-1 and formula C23H24F5N5O5.