Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC TAM557 TFA | 98.5% | 1119.34 | 1 MG
TAM557 TFA is a cytotoxic tubulysin compound designed for conjugation to transport vehicles such as proteins, peptides, small molecules, or polymeric carriers that incorporate a targeting principle. It is intended for research use only.
- Cytotoxic tubulysin compound
- Modified for conjugation to transport vehicles
- Appearance: solid, white to off-white
- Shipping at room temperature
- Store at -20°C, sealed, away from moisture and light
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Pediocin PA 1 TFA | 95.24% | 4624.12 | 1 MG
Pediocin PA 1 TFA | 95.24% | 4624.12 | 1 MG
Medchemexpress LLC NH2-UAMC1110 TFA | 2990021-73-1 | 99.9% | 545.46 g·mol⁻¹ | C23H24F5N5O5 | 10 MG
NH2-UAMC1110 TFA is the trifluoroacetic acid salt of an amino-functionalized derivative of UAMC1110. It is used as a chemical intermediate for the synthesis of FAPI-QS and other FAP-targeting imaging agents and radiotracers. The compound is supplied with high purity and is intended for research and radiochemistry applications where an amino handle is required for conjugation and labeling.
- High purity (99.89%) suitable for synthetic and radiochemistry use.
- Amino-functionalized derivative for conjugation and labeling.
- Trifluoroacetic acid salt form for improved handling and solubility.
- Intended for use as an intermediate in FAP-targeting radiotracer synthesis.
- Characterized by CAS number 2990021-73-1 and formula C23H24F5N5O5.
Medchemexpress LLC Cl2e-SN38 TFA | 99.1% | 1855.95 | C89H117F3N14O26 | 5 MG
CL2E-SN-38 TFA is an antibody-drug conjugate (ADC) drug-linker consisting of an SN-38 payload attached via a CL2E linker in the trifluoroacetate (TFA) salt form. It is intended for preclinical research into ADCs, where SN-38 functions as a topoisomerase I inhibitor.
- Highly releasable and structurally stable antibody-SN-38 conjugate.
- Contains SN-38 payload, a topoisomerase I inhibitor.
- TFA salt form for improved solubility and handling.
- Available in small research quantities (5 MG).
- High purity suitable for preclinical ADC development.
Medchemexpress LLC Psalmotoxin 1 TFA | 880107-52-8 | 99.37% | 4689.39 | 500 UG
Psalmotoxin 1 is a protein toxin that binds at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). It acts as a potent and selective ASIC1a inhibitor by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis and inhibit cell migration, proliferation, and invasion of cancer cells. It is utilized in research concerning cancers and neurological diseases.
- Potent and selective ASIC1a inhibitor with an IC50 of 0.9 nM
- Induces cell apoptosis
- Inhibits cell migration, proliferation, and invasion of cancer cells
- Used in research concerning cancers and neurological diseases
- Neuroprotective in a conscious model of stroke
- Inhibits tumor growth in breast cancer models
Medchemexpress LLC GsMTx4 | 1209500-46-8 | 99.9% | 4095.84 | 500 UG
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. It also blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 serves as a pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
- Selectively inhibits cationic-permeable mechanosensitive channels
- Blocks cation-selective stretch-activated channels
- Attenuates lysophosphatidylcholine-induced astrocyte toxicity and microglial reactivity
- Neuroprotective and inhibits demyelination
- Reduces mechanical allodynia induced by inflammation and sciatic nerve injury
Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.8% | 987.96 | 5 MG
SJ1008030 TFA is a JAK2 PROTAC that selectively degrades JAK2. It inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM and can be utilized for leukemia research. The compound is composed of a JAK2 ligand, a Cereblon ligand, and a linker.
- Selective JAK2 PROTAC degrader.
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Can be used for leukemia research.
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH-CALL-4 cells.
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating inhibition of the JAK-STAT signaling pathway.
Medchemexpress LLC TL033 TFA | 2746343-70-2 | 98.1% | 1630.83 | 5 MG
TL033 TFA (HY-147340A) is a chemical compound with CAS number 2746343-70-2 and a molecular weight of 1630.83. This product is supplied as a light yellow to yellow solid with a high purity of 98.1% (HPLC). It requires specific storage conditions to maintain its integrity, ensuring reliability for research applications.
- CAS number: 2746343-70-2
- Purity (HPLC): 98.1%
- Molecular weight: 1630.83
- Appearance: Light yellow to yellow solid
- Recommended storage (solid): -20°C, sealed, away from moisture and light
- Storage in solvent: -80°C (6 months) or -20°C (1 month), sealed, away from moisture and light
Medchemexpress LLC GRL-1720 TFA | 2835511-03-8 | C16H12ClF3N2O4 | 5 MG
GRL-1720 TFA is a potent inhibitor of SARS-CoV-2 Mpro, exhibiting anti-SARS-CoV2 activity with an EC50 value of 15 μM. This compound has a molecular weight of 388.73 and appears as a solid, ranging from light brown to brown in color.
- High purity of 98.94%.
- Shipped at room temperature.
- Store at -20°C, sealed, away from moisture.
- In solution, stable for 6 months at -80°C or 1 month at -20°C with sealed storage, away from moisture.
Medchemexpress LLC RVD-Hpα TFA | 1431329-51-9 | 99.32% | 1538.67 | 1 MG
RVD-Hpα TFA is the N-terminally extended form of human hemopressin. It functions as a selective CB1 receptor agonist, increasing intracellular Ca2+ levels in cells expressing CB1 receptors in vitro. It also acts as a high-affinity CB2 positive allosteric modulator.
- Acts as a selective CB1 receptor agonist
- Increases intracellular Ca2+ levels in CB1 receptor expressing cells
- Functions as a high-affinity CB2 positive allosteric modulator (Ki=50 nM)
Medchemexpress LLC IA9 TFA (human TREM-2 182-190 TFA) | 98.9% | 1001.31 (free acid) | 5 MG
IA9 TFA is a potent, CNS-penetrant inhibitor of Triggering Receptor Expressed on Myeloid cells 2 (TREM-2). It is capable of reducing proinflammatory cytokines and mitigating joint inflammation and damage in a Collagen-induced arthritis mouse model. This compound is suitable for neuroinflammation PET imaging and research related to rheumatoid arthritis and neuroinflammation.
Features and Benefits
- Potent CNS-penetrant TREM-2 inhibitor.
- Diminishes the release of proinflammatory cytokines.
- Suppresses joint inflammation and damage in experimental arthritis.
- Can be used for neuroinflammation PET imaging.
- Applicable for rheumatoid arthritis and neuroinflammation research.