Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Lys-CoA TFA (Lys-coenzyme A) | 98.5% | 25 MG
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). This compound inhibits p300 HAT activity-dependent transcriptional activation and is for research use only.
- Selective p300 histone acetyltransferase (HAT) inhibitor
- Displays greater than 100-fold selectivity for p300 over PCAF
- Inhibits p300 HAT activity-dependent transcriptional activation
- Induces a senescent phenotype in human normal melanocytes
Medchemexpress LLC UNC8732 TFA | 2929304-06-1 | 99.1% | 723.74 | 5 MG
UNC8732 TFA is a potent NSD2 inhibitor and degrader, designed for use in research applications. This compound plays a crucial role in studying protein degradation pathways.
- Acts as a NSD2 inhibitor.
- Functions as a protein degrader.
- Suitable for various research applications.
Medchemexpress LLC Tam557 Tfa | 98.5% | 1119.34 | 5 MG
TAM557 TFA is a cytotoxic tubulysin compound modified for conjugation to transport vehicles such as proteins, peptides, small molecules, or polymeric carriers that can carry a targeting principle. It is for research use only and not sold to patients.
- Cytotoxic tubulysin compound
- Modified for conjugation to transport vehicles
- Available in 1 mg, 5 mg, 10 mg, and 50 mg sizes
eMolecules 2411759-92-5 | Medchem Express | EZM0414 (TFA) | 5mg | 592903606 | HY-136328 | 514.522 | C24H30F4N4O4
8-Bromo-quinolin-4-ol | Chemcia | 57798-00-2 | MFCD00272389 | 224.057 | C9H6BrNO | 96.000 | Oc1ccnc2c(Br)cccc12 | 25g | 210210476
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Medchemexpress LLC Lys-CoA TFA | 98.5% | 50 MG
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). Lys-CoA TFA effectively inhibits p300 HAT activity-dependent transcriptional activation.
- Selective p300 histone acetyltransferase (HAT) inhibitor
- Displays >100-fold selectivity for p300 over PCAF
- Inhibits p300 HAT activity-dependent transcriptional activation
- Induces a senescent phenotype in human normal melanocytes at concentrations of 0.1 and 1 mM over 60 hours
- Almost completely abolished proliferation, induced high levels of SA-β-Gal, and inhibited cyclin E expression in a dose-dependent manner in normal human melanocytes
- For research use only
Medchemexpress LLC JBJ-09-063 TFA | 99.6% | 670.67 | 5 MG
JBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor with IC50s of 0.147 nM, 0.063 nM, 0.083 nM and 0.396 nM for EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S and EGFRLT/L747S. It effectively reduces EGFR, Akt and ERK1/2 phosphorylation and is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models. JBJ-09-063 TFA can be used for researching EGFR-mutant lung cancer.
- Effectively inhibits cell growth and increases apoptosis, even in gefitinib-resistant H3255GR cells with an EGFR T790M mutation.
- Shows efficacy in H1975 cells expressing osimertinib-resistant mutations.
- Exhibits IC50s of 50 nM and 6 nM in Ba/F3 cell when used alone or in combination.
- Has favorable pharmacokinetic properties and good efficacy upon oral dosing.
Medchemexpress LLC Goralatide TFA | 1796568-94-9 | 98.0% | 1 MG
Goralatide TFA is an inhibitor of cell cycle progression that enhances the selectivity of hyperthermic purging of human progenitor cells. It has potential for research related to leukemia.
- Inhibits cell cycle progression.
- Enhances selectivity of hyperthermic purging of human progenitor cells.
- Potential for leukemia research.
Apexbio Technology LLC GR 94800 TFA 5mg
GR 94800 TFA is a selective antagonist targeting neuropeptide Y (NPY) Y2 receptors Neuropeptide Y signaling via Y2 receptor subtypes participates in energy balance appetite modulation mood regulation anxiety-related behaviors and neuronal response to stress GR 94800 TFA specifically inhibits NPY Y2 receptor-mediated signaling thereby facilitating studies on the physiological and behavioral outcomes regulated by this receptor pathway It is commonly utilized by biomedical researchers investigating functions of NPY systems in feeding control emotional responses anxiety and depressive behaviors as well as cognition-related processes such as learning and memory Additionally this compound serves as an investigative tool to elucidate downstream signaling pathways and potential pharmacological targets linked to the Y2 receptor
Medchemexpress LLC PBX-7011 TFA | 98.6% | 561.46 | 1 MG
PBX-7011 TFA is a derivative of camptothecin, which inhibits the expressions of cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells. It degrades DDX5 proteins and exhibits anticancer activity. This product is for research use only and not sold to patients.
- Inhibits expression of cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP.
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
- Targets Bcl-2 family and Survivin.
- Involves the apoptosis pathway.
- Is a derivative of camptothecin.
Medchemexpress LLC Cyclo(RLsKDK) TFA | 99.7% | 841.88 | 1 MG
Cyclo(RLsKDK) TFA is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. It is utilized in research for inflammatory diseases and cancer studies.
- Specific inhibitor of metalloproteinase ADAM8 (IC50 182 nM).
- Promotes ADAM8 activation and CD23 shedding (IC50 120 nM and 182 nM).
- Increases activity of pro-ADAM8.
- Reduces tumor load and improves survival rates in pancreatic ductal adenocarcinoma (PDAC) mice models.
- Reduces sADAM8 content, pERK1/2 activation, and PDAC metastasis in vivo.
Medchemexpress LLC Cn2 toxin TFA | 96.59% | 7588.60 | 5 MG
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide identified as the main toxin found in scorpion venom. It specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6.
- Single-chain β-scorpion neurotoxic peptide
- Main toxin in scorpion venom
- Specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6
- Available in various quantities
- For research use only
Medchemexpress LLC FTO-IN-1 TFA | 2797619-81-7 | 98.1% | 505.27 | 1 ML
FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32. It can be used for the research of cancer and is for research use only.
- FTO inhibitor with an IC50 of <1 μM
- Inhibits FTO enzyme activity by 62% in vitro at 50 μM
- Inhibits the viability of SCLC-21H, RH30 and KP3 cells with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively
![Medchemexpress LLC (2S)-2-amino-3-[(3-fluorophenyl)-(2-phenylmethoxyphenyl)methoxy]propanoic acid; TFA | 00-00-0 | 99.8% | 509.45 g·mol⁻¹ | C25H23F4NO6 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000263712.png-250.jpg)
Medchemexpress LLC (2S)-2-amino-3-[(3-fluorophenyl)-(2-phenylmethoxyphenyl)methoxy]propanoic acid; TFA | 00-00-0 | 99.8% | 509.45 g·mol⁻¹ | C25H23F4NO6 | 5 MG
ALX-1393 TFA is the trifluoroacetate salt of a selective glycine transporter 2 (GlyT2) inhibitor used as a research reagent to investigate glycinergic neurotransmission and nociception. It is supplied as a purified solid for laboratory use and has reported antinociceptive activity in rodent pain models.
- Selective GlyT2 inhibitor for probing glycinergic neurotransmission.
- Research-grade solid suitable for in vitro and in vivo studies.
- High purity (99.83%) supporting reproducible results.
- Molecular formula C25H23F4NO6 and molecular weight 509.45 g·mol⁻¹.
- Store at -20°C to maintain stability and minimize moisture exposure.
Medchemexpress LLC ACV Tripeptide TFA | 477.45 | 25 MG
ACV Tripeptide TFA is a tripeptide that serves as the initial dedicated intermediate in the biosynthetic pathway leading to penicillin and cephalosporin classes of β-lactam natural products in bacteria and fungi. It is nonribosomally synthesized by the ACV synthetase (ACVS) enzyme, encoded by the 11 kb *pchAB* gene, and can be used for the biosynthesis of β-lactam antibiotics. This tripeptide contains the unusual amino acid α-aminoadipic acid (α-AAA), along with L-cysteine and D-valine.
- Tripeptide
- Initial intermediate in β-lactam biosynthesis
- Synthesized by ACV synthetase (ACVS) enzyme
- Contains α-aminoadipic acid (α-AAA), L-cysteine, and D-valine
- Molecular weight: 477.45
- Formula: C16H26F3N3O8S
- Appearance: Solid
Strem, An Ascensus Company CAS# 76-05-1. 100g. Trifluoroacetic acid, 99%. MFCD00004169
CAS# 76-05-1. 100g. Trifluoroacetic acid, 99%. MFCD00004169. Molecular Weight: 114.02. Molecular Formula: CF3COOH. Color/form: colorless liq. Strem# 09-7160. http://www.strem.com/catalog/v/09-7160/
