Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Sigma Aldrich Fine Chemicals Biosciences TRIFLUOROACETIC ACID 100ML
NC3241523 TRIFLUOROACETIC ACID 100ML
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid 99 fo25G
TRIFLUOROACETIC Trifluoroacetic acid 99 fo25G
Medchemexpress LLC MM-401 (TFA) | 1442106-11-7 | 99.3% | 700.75 | 5 MG
MM-401 (TFA) is an inhibitor of MLL1 H3K4 methyltransferase. It works by blocking the interaction between MLL1 and WDR5, thereby inhibiting MLL1 activity with an IC50 of 0.32 μM. This compound can induce cell cycle arrest, apoptosis, and differentiation. It is used in research for MLL leukemia.
- Inhibits MLL1 H3K4 methyltransferase
- Blocks MLL1-WDR5 interaction
- Potent inhibition of MLL1 activity
- Induces cell cycle arrest
- Promotes apoptosis
- Facilitates differentiation
- Useful for research of MLL leukemia
- Specifically inhibits MLL1-dependent H3K4 methylation in cells
- Inhibits growth of MLL leukemia cells
- Affects MLL-AF9 transcriptome
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC), 76-05-1, MFCD00004169
Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC)
Medchemexpress LLC Vasopressin-d5 TFA (Arginine vasopressin-d5 TFA) | 113-79-1 | 5MG
Vasopressin-d5 TFA is the TFA salt form of Vasopressin-d5 and is an isotope-labeled compound of Vasopressin. Vasopressin is a cyclic nonapeptide produced in the hypothalamus. It is involved in the hypothalamic-pituitary-adrenal axis, regulating pituitary corticotropin secretion by enhancing the stimulatory effects of corticotropin-releasing factor. Additionally, Vasopressin acts as a neurotransmitter by binding to specific G protein-coupled receptors.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Cyclo(RGDyC) TFA | 95.68% | 594.64 | 1 MG
Cyclo(RGDyC) TFA is a cyclic pentapeptide with anti-angiogenic abilities. It can be combined with liposome delivery systems for research on ocular neovascular diseases and cancer.
- Cyclic pentapeptide
- Anti-angiogenic abilities
- Contains the alphaVbeta3 integrin-binding sequence arginine-glycine-aspartate (RGD)
- Can be used to target tumors and ocular neovasculature
- White to off-white solid appearance
- Soluble in H2O
Medchemexpress LLC Tmprss6-in-1 Tfa | 1 MG
Tmprss6-in-1 TFA is a potent inhibitor of Tmprss6 (Matriptase-2), a type II transmembrane serine protease (TTSP). Genetic reduction of Tmprss6 has shown to improve symptoms of hemochromatosis and beta thalassemia in mice.
- Potent inhibitor of Tmprss6 (Matriptase-2)
- Belongs to transmembrane serine proteases (TTSPs)
- Molecular weight: 790.88
- Formula: C35H41F3N8O6S2
- Appearance: Solid
- Soluble in Dmso at 125 mg/mL (158.05 mM)
- Target: Ser/Thr protease
- Pathway: Metabolic enzyme/protease
- For research use only
Medchemexpress LLC VTP-27999 (TFA) | 1013937-63-7 | 97.0% | C28H42ClF3N4O7 | 5 MG
VTP-27999 (TFA) is an alkyl amine Renin inhibitor useful for hypertension and end-organ diseases. This product is for research use only.
- Alkyl amine Renin inhibitor
- Useful for hypertension research
- Useful for end-organ diseases research
- For research use only
Medchemexpress LLC Ac-VEID-CHO (trifluoroacetate salt) | 00-00-0 | 99.8% | 614.57 Da | C24H37F3N4O11 | 1 MG
Ac-VEID-CHO (TFA) is a peptide-derived reversible caspase inhibitor intended for in vitro research into apoptosis and neurodegenerative pathways. It is supplied as a trifluoroacetate salt and demonstrates potent inhibition of several executioner caspases in biochemical assays. Not for human or clinical use.
- Reversible caspase inhibitor targeting caspase-6, caspase-3, and caspase-7.
- Reported IC50 values in the low nanomolar range for primary targets.
- High purity suitable for biochemical assays (99.8%).
- Available in small mg-scale quantities for research use.
- Limited cellular activity due to poor cellular accumulation.
Medchemexpress LLC Glycyl-Exatecan (TFA) | 1883333-57-0 | 96.9% | 10 MG
Glycyl-Exatecan TFA is a derivative of Exatecan and acts as an anticancer agent. It demonstrates significant antitumor activity.
- Acts as an anticancer agent
- Demonstrates significant antitumor activity
- Suitable for research on cancers such as solid tumors
- Derivative of Exatecan