Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Acyline TFA | 99.8% | 1647.23 | 5 MG
Acyline TFA, a GnRH peptide analogue, is a GnRH antagonist that inhibits gonadotropin and testosterone (T) levels.
- Disrupts vaginal oestrus and reduces uterine weights in female Kiss1-/- and Gpr54-/- mice.
- Decreases luteinizing hormone (LH) concentrations in female Kiss1-/- mice.
- Reduces follicle stimulating hormone (FSH) concentrations in male Kiss1-/- and Gpr54-/- mice.
Medchemexpress LLC MC-VC-PAB-NH2 TFA | 1616727-21-9 | MFCD00935992 | 99.9% | 772.77 | C33H47F3N8O10 | 5 MG
MC-VC-PAB-NH2 TFA is a cleavable antibody-drug conjugate (ADC) linker used to attach cytotoxic payloads to antibodies and enable intracellular release through enzymatic cleavage. It contains a valine-citrulline dipeptide and a para-aminobenzyl self-immolative spacer and is supplied as the trifluoroacetate salt for stability in research applications.
- Cleavable valine-citrulline linker for cathepsin-mediated payload release.
- Para-aminobenzyl self-immolative spacer to facilitate efficient drug release.
- Supplied as a trifluoroacetate salt for improved stability and handling.
- High purity suitable for research use.
- Soluble in DMSO at high concentration; ultrasonic assistance may be required.
- Store sealed, away from moisture and light; follow recommended low-temperature storage for solutions.
Medchemexpress LLC NLS-StAx-h TFA | 2872559-21-0 | 98.9% | 3559.28 | 100 UG
NLS-StAx-h TFA is a selective, cell-permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. It efficiently inhibits β-catenin-transcription factor interactions and demonstrates anti-proliferation effects on cancer cells, making it suitable for research into Wnt signaling pathways.
- Efficiently inhibits β-catenin-transcription factor interactions
- Shows anti-proliferation effects on cancer cells
- Reduces the viability of SW-480 and DLD-1 colorectal cancer cells by more than 80%
- Inhibits the migration of colorectal cancer cells in a dose-dependent manner
Medchemexpress LLC Hexa-His TFA | 1456728-20-3 | 99.8% | 954.87 | 25 MG
Hexa-His TFA is a peptide consisting of 6 His residues, used as a metal binding site for the recombinant protein.
- Consists of 6 His residues
- Used as a metal binding site
- Suitable for recombinant protein applications
- Molecular weight of 954.87
- Purity of 99.8%
- Appearance is solid, white to off-white
- Recommended storage for powder: -80°C for 2 years or -20°C for 1 year
- Recommended storage in solvent: -80°C for 6 months or -20°C for 1 month
- Store sealed and away from moisture
Medchemexpress LLC 4,7,10,13,16-pentaazanonadecanedioic acid ester (TFA) | MFCD34677028 | 98.6% | 1841.72 (free base) | C93H173N5O20S5·xC2HF3O2 | 5 MG
5A2-SC8 TFA is an ionizable amino lipid provided as the trifluoroacetic acid salt for formulation into lipid nanoparticles (LNPs). It is intended for research use to enable efficient delivery of small RNAs, such as siRNA and miRNA, and has documented low in vivo toxicity and COA-verified purity.
- Ionizable amino lipid suitable for LNP formulation.
- Enhances delivery of siRNA and miRNA to target cells.
- Low in vivo toxicity profile reported.
- Provided as the TFA salt to aid formulation and handling.
- COA-verified purity by HPLC (~98.6%).
- Store at -80 °C and protect from light for stability.
Medchemexpress LLC DAMGO TFA | 950492-85-0 | 99.5% | 627.61 | 25 MG
DAMGO TFA is a selective agonist for the μ-opioid receptor (μ-OPR) with a Kd of 3.46 nM for native μ-OPR. It significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, without down-regulating CXCR4 protein expression. It is for research use only.
- Effectively inhibits prostaglandin E2 (PGE2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa).
- Produces significant anti-injury effects.
- Exhibits long-lasting analgesic effects in a dose-dependent manner.
TARGETMOL CHEMICALS INC CYN 154806 TFA 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. CYN 154806 TFA is a cyclic octapeptide and an effective selective somatostatin sst2 receptor antagonist. For the recombinant sst2, sst1, sst3, sst4 and sst5 receptors, the pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48, respectively. Purity 99.7%