Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Pfaltz & Bauer Trifluoroacetic acid anhydride 100G | 407-25-0
Trifluoroacetic acid anhydride 100G | 407-25-0
![Medchemexpress LLC Carbamic acid, N-methyl-N-[2-(methylamino)ethyl] ester, 2,2,2-trifluoroacetate | 1224601-17-5 | MFCD01938808 | 98.1% | 620.57 g/mol | C29H31F3N4O8 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000201969.png-250.jpg)
Medchemexpress LLC Carbamic acid, N-methyl-N-[2-(methylamino)ethyl] ester, 2,2,2-trifluoroacetate | 1224601-17-5 | MFCD01938808 | 98.1% | 620.57 g/mol | C29H31F3N4O8 | 1 ML
SN-38-CO-DMEDA TFA is a research-grade carbamate intermediate (trifluoroacetate salt) used in the synthesis of antibody-drug conjugates such as LND1035. Supplied as a 10 mM solution in DMSO (1 mL), it has CAS number 1224601-17-5, chemical formula C29H31F3N4O8, molecular weight 620.57 g/mol, and reported purity 98.07%.
- 10 mM solution in DMSO, 1 mL
- Intended for use as a chemical synthesis intermediate
- Reported purity 98.07%
- CAS number 1224601-17-5
- Available as solid quantities in multiple sizes
Medchemexpress LLC FRETS-VWF73 | 97.3% | 8314.28 | 1 MG
FRETS-VWF73 is a 73-amino-acid peptide that serves as a fluorogenic substrate for the ADAMTS13 assay (Ex = 340 nm; Em = 450 nm). It is utilized as a predictive tool for thrombotic thrombocytopenic purpura and is intended for research use only.
- Functions as a fluorogenic substrate for ADAMTS13 assay
- Predictive tool for thrombotic thrombocytopenic purpura
- Excitation wavelength: 340 nm
- Emission wavelength: 450 nm
- Purity: 97.3%
- Molecular weight: 8314.28
- Appearance: Solid, light yellow to yellow
- Solubility: 25 mg/mL in DMSO
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 25 MG
Relamorelin TFA is a pentapeptide ghrelin analog and a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for the GHS-1a receptor. It is centrally penetrant, increases growth hormone levels, and accelerates gastric emptying. This compound has potential for research into cachexia, gastroparesis, and gastric/intestinal dysmobility disorders.
- Pentapeptide ghrelin analog
- Selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist
- Ki of 0.42 nM for GHS-1a receptor
- Centrally penetrant
- Increases growth hormone levels
- Accelerates gastric emptying
- Shows ~3 times greater affinity for GHS-1a (Ki=0.42 nM) than native ghrelin (Ki=1.12 nM)
- 6 times more potent (EC50=0.71 nM) in activating the GHS-1a receptor than native ghrelin (EC50=4.2 nM) in vitro by calcium mobilization
- Solid appearance, white to off-white color
- For research use only.
Medchemexpress LLC Gplgiagq tfa | 99.9% | 825.83 | 50 MG
GPLGIAGQ TFA is an MMP2-cleavable polypeptide used as a stimulus-sensitive linker in liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. It can also be utilized to synthesize unique MMP2-targeted photosensitizers in photodynamic therapy (PDT). This product is for research use only.
- Used as a stimulus-sensitive linker in liposomal and micellar nanocarriers for tumor targeting
- Can be utilized to synthesize unique MMP2-targeted photosensitizers in photodynamic therapy (PDT)
- For research use only
- MMP2-cleavable polypeptide
- Target: MMP2
- Molecular weight: 825.83
- Formula: C33H54F3N9O12
- Appearance: solid, white to off-white
- Sequence: Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln
Medchemexpress LLC VU0364572 TFA | 1240514-89-9 | 99.3% | 487.51 | 1 ML
VU0364572 TFA is an orally active, selective, allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. It has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's Disease and is CNS penetrant.
- Acts as an orally active and selective allosteric agonist of the M1 muscarinic receptor.
- Features an EC50 of 0.11 μM.
- Demonstrates neuroprotective potential.
- Aids in preventing memory impairments and reducing neuropathology in Alzheimer's Disease.
- Is CNS penetrant.
Medchemexpress LLC Mi-1061 Tfa | 1410737-35-7 | 97.5% | 696.47 | C32H27Cl2F4N3O6 | 25MG
MI-1061 TFA is the trifluoroacetate (TFA) salt of MI-1061, a potent, orally bioavailable inhibitor of the MDM2-p53 protein-protein interaction. It activates p53, induces apoptosis in tumor models, and shows selective activity in p53 wild-type cell lines.
- Potent biochemical MDM2-p53 interaction inhibitor (IC50 = 4.4 nM; Ki = 0.16 nM).
- Selective cellular activity with IC50 = 100 nM in SJSA-1 and 250 nM in HCT-116 p53+/+; >10,000 nM in p53-/- cells.
- Trifluoroacetate salt presented as a solid form.
- Molecular weight 696.47 and molecular formula C32H27Cl2F4N3O6.
- Intended for research use as a tool compound to study p53 activation and antitumor effects.
- Purity listed as 97.47%.
Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.8% | 987.96 | 5 MG
SJ1008030 TFA is a JAK2 PROTAC that selectively degrades JAK2. It inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM and can be utilized for leukemia research. The compound is composed of a JAK2 ligand, a Cereblon ligand, and a linker.
- Selective JAK2 PROTAC degrader.
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Can be used for leukemia research.
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH-CALL-4 cells.
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating inhibition of the JAK-STAT signaling pathway.
Medchemexpress LLC Lys-bradykinin TFA | 00-00-0 | 99.9% | 1188.38 g/mol (free base) | C56H85N17O12 · xC2HF3O2 | 25 MG
Lys-bradykinin TFA is the trifluoroacetate salt form of the decapeptide kallidin (Lys-bradykinin). It is used as a research reagent and acts as a ligand for kallidin and bradykinin receptors, supporting studies in vascular regulation, inflammation, and pain signaling.
- TFA salt form of lys-bradykinin (kallidin).
- High purity (≈99.85%).
- Molecular weight 1188.38 g/mol (free base).
- Provided in small quantities suitable for biochemical assays; 25 mg size available.
- Intended for receptor binding and vascular biology research applications.
eMolecules 76-05-1 | Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 500g | 537709017
Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 500g | 537709017
