Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Veldoreotide TFA | 2126831-23-8 | 99.0% | 1237.33 | 5 MG
Veldoreotide TFA (DG3173) is a somatostatin analogue that binds to and activates somatostatin receptors (SSTR) 2, 4, and 5. It inhibits growth hormone (GH) secretion in adenomas and has potential use as a pain modulating agent.
- Activates somatostatin receptors 2, 4, and 5
- Inhibits growth hormone (GH) secretion in adenomas
- May be used as a pain-modulating agent
- Stimulates SST2, SST4, and SST5 receptors in HEK293 cells co-expressing these receptors with GIRK2 channels
- Inhibits SST4-expressing BON-1 cells at 10 μM for 24 hours
Medchemexpress LLC Pepinh-MYD TFA | 1421052-89-2 | 98.9% | 3388.03 | 5 MG
Pepinh-MYD TFA is a MyD88 inhibitor designed to interfere with MyD88-mediated TLR signaling pathways. It contains a domain sequence from MyD88 TIR and a protein transduction sequence, enabling cell membrane penetration and inhibition of related immune responses. This compound shows potential for studying the role of MyD88 in viral infections, including COVID-19.
- Acts as a MyD88 inhibitor
- Contains a domain sequence from MyD88 TIR
- Includes a protein transduction sequence for cell membrane penetration
- Interferes with MyD88-mediated TLR signaling pathways
- Inhibits immune responses
- Suitable for studying the role of MyD88 in viral infections
- Applicable in COVID-19 anti-virus research
Medchemexpress LLC Pam2CSK4 (TFA) | 99.5% | 1271.82 (free base) | 5 MG
Pam2CSK4 (TFA) is a lipopeptide that acts as a TLR6-independent TLR2 ligand and agonist. It promotes platelet aggregation and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages.
- Acts as a TLR6-independent TLR2 ligand and agonist.
- Promotes platelet aggregation.
- Increases platelet adhesion to collagen-coated surfaces.
- Activates iNOS expression and NO production in mouse macrophages.
Medchemexpress LLC Astressin 2B TFA | 99.5% | 4041.69 (free base) | 5 MG
Astressin 2B TFA | 99.5% | 4041.69 (free base) | 5 MG
Medchemexpress LLC Mp6 (TFA) | 98.5% | 5 MG
mP6 (Myr-FEEERA-OH) is a myristoylated peptide and an integrin β3 inhibitor. It prevents the interaction of Gα13 with integrin β3 while preserving talin-dependent integrin function. This peptide also blocks the GTP usage of Rac1, Rap1, and Rab7, which effectively inhibits the infection of CHO-A24 cells.
- Myristoylated peptide
- Inhibits Gα13-integrin β3 interaction
- Preserves talin-dependent integrin function
- Blocks GTP usage of Rac1, Rap1, and Rab7
- Inhibits infection of CHO-A24 cells
- For research use only
Medchemexpress LLC Huwentoxin-IV TFA | 526224-73-7 | 4106.78 | 500 UG
Huwentoxin-IV is a potent and selective sodium channel blocker. It inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4, with preferential blocking of peripheral nerve subtype Nav1.7. This compound has also demonstrated analgesic effects in animal models of inflammatory and neuropathic pain.
- Potent and selective sodium channel blocker
- Inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4
- Preferentially blocks peripheral nerve subtype Nav1.7
- Binds to neurotoxin receptor site 4
- Analgesic effects in animal models of inflammatory and neuropathic pain
Medchemexpress LLC Cyclo(RLsKDK) TFA | 99.7% | 841.88 | 1 MG
Cyclo(RLsKDK) TFA is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. It is utilized in research for inflammatory diseases and cancer studies.
- Specific inhibitor of metalloproteinase ADAM8 (IC50 182 nM).
- Promotes ADAM8 activation and CD23 shedding (IC50 120 nM and 182 nM).
- Increases activity of pro-ADAM8.
- Reduces tumor load and improves survival rates in pancreatic ductal adenocarcinoma (PDAC) mice models.
- Reduces sADAM8 content, pERK1/2 activation, and PDAC metastasis in vivo.
Medchemexpress LLC Adrixetinib (TFA) | 2394874-66-7 | C27H25F6N5O7 | 1 ML
Adrixetinib (TFA) is a protein tyrosine kinase (PTK) inhibitor (antagonist) with anti-tumor effects.
- Molecular formula: C27H25F6N5O7.
- Molecular weight: 645.51.
- Appearance: Off-white to light yellow solid.
- Purity (HPLC) of 99.82%.
- Recommended storage at 4°C in sealed conditions, away from moisture.
- When in solvent, store at -80°C for up to 6 months or -20°C for up to 1 month, under sealed conditions and away from moisture.
Medchemexpress LLC TfR-T12 TFA | 99.1% | 1604.75 | 1 MG
TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide. It binds to the TfR and is subsequently internalized into TfR-expressing cells, making it suitable for research applications.
- Displays a binding affinity in the nM range.
- Synthetic peptide obtained by phage display.
- Binds to a different site on TfRs compared with transferrin.
- Can be chemically conjugated to construct multifunctional lipid vesicles.
Medchemexpress LLC SIYNFEKL TFA | 99.9% | 1013.14 (free acid) | 5 MG
SIYNFEKL TFA is an antigenic peptide, a variant of the major MHC class I-restricted epitope SIINFEKL. It stimulates specific T cells in experimental settings to study competitive interactions between T cells.
- Stimulates specific T cells
- Used to study competitive interaction between T cells
- Exhibits low affinity for OT-I T cell receptor (TCR)
- Applicable for detection of CD8+ T cells
Medchemexpress LLC TcY-NH2 TFA ((trans-cinnamoyl)-YPGKF-NH2 TFA) | 1262750-73-1 | 99.7% | 853.88 | 10 MG
tcY-NH2 TFA is a potent and selective PAR4 antagonist peptide. It is capable of inhibiting thrombin- and AY-NH2-induced platelet aggregation and endostatin release. This peptide is suitable for research applications in inflammation and immunology.
- Potent and selective PAR4 antagonist peptide.
- Inhibits thrombin- and AY-NH2-induced platelet aggregation.
- Prevents endostatin release.
- Suitable for inflammation and immunology research.
- Purity of 99.7%.
- Soluble in DMSO at 100 mg/mL.
- Demonstrated activity in various in vitro and in vivo models.
Medchemexpress LLC Ela-32(human) (tfa) | 99.9% | 3967.82 | 1 MG
ELA-32(human) TFA is a potent, high affinity apelin receptor agonist with an IC50 of 0.27 nM and a Kd of 0.51 nM. This product does not bind to GPR15 and GPR25. It activates the PI3K/AKT pathway, promoting the self-renewal of hESCs via cell-cycle progression and protein translation. Additionally, it potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage, and stimulates angiogenesis in HUVEC cells.
- Potent, high affinity apelin receptor agonist
- IC50 of 0.27 nM and a Kd of 0.51 nM
- Exhibits no binding to GPR15 and GPR25
- Activates the PI3K/AKT pathway
- Promotes self-renewal of hESCs via cell-cycle progression and protein translation
- Potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage
- Stimulates angiogenesis in HUVEC cells
Medchemexpress LLC GsMTx4 TFA | 99.9% | 4095.84 | 1 MG
GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. It also blocks cation-selective stretch-activated channels (SACs) and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity, making it a pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
- Selectively inhibits cationic-permeable mechanosensitive channels (MSCs)
- Blocks cation-selective stretch-activated channels (SACs)
- Attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity
- Attenuates microglial reactivity
- Useful as a pharmacological tool for identifying the role of excitatory mechanosensitive channels