Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Adrixetinib (TFA) | 2394874-66-7 | C27H25F6N5O7 | 1 ML
Adrixetinib (TFA) is a protein tyrosine kinase (PTK) inhibitor (antagonist) with anti-tumor effects.
- Molecular formula: C27H25F6N5O7.
- Molecular weight: 645.51.
- Appearance: Off-white to light yellow solid.
- Purity (HPLC) of 99.82%.
- Recommended storage at 4°C in sealed conditions, away from moisture.
- When in solvent, store at -80°C for up to 6 months or -20°C for up to 1 month, under sealed conditions and away from moisture.
Medchemexpress LLC NH2-UAMC1110 TFA | 2990021-73-1 | C23H24F5N5O5 | 5 MG
NH2-UAMC1110 TFA | 2990021-73-1 | C23H24F5N5O5 | 5 MG
Medchemexpress LLC CRA-2059 TFA | 99.9% | 864.83 | 1 ML
CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ). Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 has the potential for inflammatory bowel disease research.
- Highly specific and selective tryptase inhibitor
- Potential for inflammatory bowel disease research
- Inhibits recombinant human tryptase-β (rHTβ) with a Ki of 620 pM
- Targets tryptase, a trypsin-like serine protease
Medchemexpress LLC DX600 TFA | 99.2% | 3074.33 (free acid) | 1 MG
DX600 TFA is a selective ACE2 specific inhibitor (KD: 1.3 nM) that does not cross-react with ACE. It has been observed to exacerbate diabetes-induced cardiovascular dysfunction and increase cardiac and renal NOX activity. It is for research use only.
- Selective ACE2 specific inhibitor
- Does not cross-react with ACE
- Exacerbates diabetes-induced cardiovascular dysfunction
- Increases cardiac and renal NOX activity
Medchemexpress LLC Hr97 Tfa | 1518.84 | 1 MG
HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops called HR97-SunitiGel. The peptide-drug conjugate can provide sustained ocular drug delivery.
- Cell-penetrating peptide
- Combines with engineered melanin to prepare eye drops
- Supports sustained ocular drug delivery
- Sequence: Phe-Ser-Gly-Lys-Arg-Arg-Lys-Arg-Lys-Pro-Arg-Cys
- Shortened sequence: FSGKRRKRKPRC
- In vitro solubility: 50 mg/mL in DMSO (need ultrasonic)
Medchemexpress LLC Biotin-COG1410 TFA | 98.0% | 1 MG
Biotin-COG1410 TFA is a biotin-labeled COG1410. COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. It exerts neuroprotective and anti-inflammatory effects in a murine model of traumatic brain injury (TBI) and can be used for the research of neurological diseases.
- Decreases the production and release of NO and TNFα in BV2 microglia cells.
- Exhibits significant improvement on vestibulomotor function and spatial learning and memory in mice.
- Improves vestibulomotor function, decreases poststroke locomotor asymmetry, and decreases infarct volume of the ipsilateral hemisphere in rats.
Medchemexpress LLC Huwentoxin-IV TFA | 526224-73-7 | 4106.78 | 500 UG
Huwentoxin-IV is a potent and selective sodium channel blocker. It inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4, with preferential blocking of peripheral nerve subtype Nav1.7. This compound has also demonstrated analgesic effects in animal models of inflammatory and neuropathic pain.
- Potent and selective sodium channel blocker
- Inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4
- Preferentially blocks peripheral nerve subtype Nav1.7
- Binds to neurotoxin receptor site 4
- Analgesic effects in animal models of inflammatory and neuropathic pain
Medchemexpress LLC Spinorphin (TFA) | 2828433-21-0 | 99.4% | 991.06 | 5 MG
Spinorphin TFA is an inhibitor of enkephalin-degrading enzymes. It inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme, and enkephalinase. Spinorphin also has an antinociceptive effect.
- For research use only
Medchemexpress LLC F9170 (TFA) | >98% | 2097.33 | 1 MG
F9170 (trifluoroacetate salt) is an antiviral peptide that corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein. This product is identified as a laboratory chemical for the manufacture of substances and is strictly for research use only. It must be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- Antiviral peptide.
- Corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein.
- Intended for research use only.
- Suitable for laboratory chemical applications.
- Recommended for handling by experienced personnel.
Medchemexpress LLC DPC-AJ1951 (TFA) | 99.4% | 1666.99 (free base) | 1 MG
DPC-AJ1951 TFA is a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). Its activity has been characterized in ex vivo and in vivo assays of bone resorption. In vitro, it induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR.
- Acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR)
- Activity characterized in ex vivo and in vivo assays of bone resorption
- Induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR
- 14 amino acid peptide
Medchemexpress LLC L-Serine, L-alanyl-L-prolyl-L-prolyl-L-histidyl-L-alanyl-L-leucyl- (TFA) | 99.87% | 805.80 | 25 MG
RS 09 TFA is an LPS peptide mimic and a TLR4 agonist. It binds to TLR-4, activating NF-κB, and functions as an adjuvant in vivo to enhance the antigen-specific immune response.
- Acts as an LPS peptide mimic and TLR4 agonist.
- Binds to TLR-4 and activates NF-κB.
- Enhances antigen-specific immune response in vivo.
- Stimulates TLR-4 and activates NF-κB in HEK-BLUETM-4 cells.
- Induces nuclear translocation of NF-κB and secretion of inflammatory cytokines in RAW264.7 cells.
Medchemexpress LLC Stressin I TFA | 98.63% | 4472.20 (free base) | 1 MG
Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent and selective agonist for the CRF1 receptor, intended for research use only. It has been shown to increase adrenocorticotropic hormone (ACTH) levels in rats.
- Potent CRF1 receptor selective agonist
- Ki of 1.7 nM
- Increases adrenocorticotropic hormone (ACTH) levels in rats