Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Box5 (TFA) | 00-00-0 | 99.2% | 880.9 Da | C32H51F3N6O15S2.xC2HF3O2 | 5 MG
Box5 TFA is the trifluoroacetate salt form of a peptide antagonist of Wnt5a used in vitro to study Wnt5a-mediated signaling, calcium release, and cell migration. Supplied in small milligram vials, the material is provided with documentation to support research use.
- Trifluoroacetate salt form for improved solubility and handling.
- Potent antagonist of Wnt5a signaling for pathway studies.
- Inhibits Wnt5a-mediated calcium release and cell migration.
- High purity approximately 99.2% for consistent results.
- Supplied in small milligram sizes suitable for in vitro experiments.
- COA and SDS available for quality and safety verification.
Medchemexpress LLC Batifiban TFA | 00-00-0 | 99.6% | 817.94 g/mol | C34H47N11O9S2 · xC2HF3O2 | 5 MG
Batifiban TFA is a cyclic peptide antagonist of platelet glycoprotein IIb/IIIa that inhibits platelet aggregation by blocking ligand binding such as vitronectin. Supplied as the trifluoroacetate (TFA) salt for research use, it is provided as a high-purity powder suitable for in vitro biochemical and cellular assays.
- Antagonizes platelet glycoprotein IIb/IIIa to inhibit aggregation.
- Blocks vitronectin binding to integrin receptors.
- Supplied as trifluoroacetate (TFA) salt for stability.
- High purity (~99.6%) suitable for biochemical assays.
- Available in small research pack sizes, including 5 mg.
- Store sealed, away from moisture and light; long-term storage at -80°C.
Medchemexpress LLC Amg 7905 (tfa) | 00-00-0 | 99.1% | 597.58 | C27H25F6N5O2S | 5 MG
AMG 7905 TFA is the trifluoroacetate salt of AMG 7905, a potent transient receptor potential vanilloid 1 (TRPV1) antagonist used in research. It potentiates proton-enhanced TRPV1 activation while blocking capsaicin-induced channel responses, and has been used to study thermoregulation and TRP channel physiology. The compound is supplied as a high-purity research reagent for in vitro and in vivo studies.
- Potent TRPV1 antagonist activity.
- Modulates proton-enhanced channel activation and blocks capsaicin responses.
- High purity (≈99.1%).
- Provided as the trifluoroacetate (TFA) salt to aid handling and solubility.
- Available in small research pack sizes suitable for pilot studies.
- Intended for laboratory research use only.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC), 76-05-1, MFCD00004169
Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC)
