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Acyl bromides

Organic compounds that contain an acyl group bonded to a bromide ion; an acyl group is a carbon atom bonded to an alkyl functional group, and an oxygen atom via a double bond.

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1

Medchemexpress LLC KRN2 bromide | 1390654-28-0 | 98.8% | 524.38 | 1 ML
SDP

KRN2 (bromide) is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. It is for research use only and not sold to patients.

  • Selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6.
  • Dose-dependently inhibits the NF-κB p65 binding to Nfat5 promoter 1.
  • Directly blocks the interaction between NF-κB p65 and its DNA binding sequence.
  • Effectively suppresses AIA and CIA in mice.
  • Decreases the production of pro-inflammatory cytokines and autoantibodies.
  • Reduces macrophage infiltration.

ENCOMPASS_PREFERRED
2

Medchemexpress LLC KRN2 bromide | 1390654-28-0 | 98.8% | 524.38 | 25 MG
SDP

KRN2 bromide is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. It selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6. It also dose-dependently inhibits NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence.

  • Selectively inhibits nuclear factor of activated T cells (NFAT5).
  • Suppresses expression of pro-inflammatory genes.
  • Inhibits NF-κB p65 binding to Nfat5 promoter.
  • Effectively suppresses AIA and CIA in mice, decreasing pro-inflammatory cytokines and autoantibodies.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 13-[(2-fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy- | 1390654-28-0 | 98.8% | 524.38 | 10 MG
SDP

Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 13-[(2-fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy- | 1390654-28-0 | 98.8% | 524.38 | 10 MG

ENCOMPASS_PREFERRED
4

Medchemexpress LLC (2e)-1-(3,4-dimethoxyphenyl)-5-fluoro-3-(4-fluorophenyl)-2-(2-fluorophenyl)pent-1-en-4-one bromide | 1390654-28-0 | >98.8% | 524.38 | 100 MG
SDP

KRN2 bromide is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. It selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hindering high-salt-induced NFAT5 and its target gene expressions. KRN2 also dose-dependently inhibits NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site of Nfat5 exon 1.

  • Effectively suppresses AIA in which innate immune cells play a predominant role.
  • Effectively suppresses CIA as well as AIA in mice.
  • Decreases the production of pro-inflammatory cytokines and autoantibodies.
  • Reduces macrophage infiltration.

ENCOMPASS_PREFERRED