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Alkyl bromides

Organic compounds in which a hydrogen atom or more has been replaced by a bromide ion in an alkane molecule (saturated hydrocarbon chain).

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1

Medchemexpress LLC Mk-4101 | 935273-79-3 | MFCD30343842 | 99.2% | 493.47 g/mol | C24H24F5N5O | 5 MG
SDP

MK-4101 is a research-use small-molecule Smoothened (SMO) antagonist that inhibits the Hedgehog signaling pathway and shows antiproliferative and pro-apoptotic activity in tumor cell models. Chemical formula C24H24F5N5O, molecular weight 493.47 g/mol, CAS 935273-79-3, purity ~99.16%.

  • Smoothened (SMO) antagonist activity with Hedgehog pathway inhibition.
  • Demonstrated antiproliferative and pro-apoptotic effects in tumor cell models.
  • Reported IC50 values: 1.1 μM (293 cells), 1.5 μM (mouse cells), 1.0 μM (KYSE180).
  • High reported chemical purity (~99.2%).
  • Available as solid and DMSO solution formats for flexible use.
  • For research use only; not for human therapeutic use.

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2

Selleck Chemical LLC MK-4101
SDP

MK-4101 a potent inhibitor of the Hedgehog pathway shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells

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3

Medchemexpress LLC Benzoic acid, 3-fluoro-5-(2-pyridinyl)-, 2-[(2-fluorophenyl) sulfonyl] hydrazide | 2055397-28-7 | MFCD31690337 | 99.6% | 389.38 | 5 MG
SDP

WM-1119 is a highly potent and selective KAT6A inhibitor, functioning as a chemical probe. It demonstrates anti-cancer efficacy both in vitro and in vivo by inhibiting MYST family histone acetyltransferases KAT6A and KAT6B. This compound induces cell cycle exit and cellular senescence without causing DNA damage, and it has shown to arrest tumor growth and significantly reduce tumor burden in animal models.

  • Acts as a highly potent and selective KAT6A inhibitor
  • Exhibits an IC50 of 0.25 μM for KAT6A in lymphoma cells
  • Shows 1,100-fold greater activity against KAT6A than KAT5
  • Demonstrates 250-fold greater activity against KAT6A than KAT7
  • Induces cell cycle exit and cellular senescence in MEFs
  • Inhibits the proliferation of EMRK1184 lymphoma cells
  • Well-tolerated in in vivo studies without generalized ill effects

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4

Medchemexpress LLC 3-fluoro-5-(2-pyridinyl)benzoic acid, 2-[(2-fluorophenyl)sulfonyl]hydrazide | 2055397-28-7 | MFCD31690337 | >=98% | 389.4 g/mol | C18H13F2N3O3S | 25 MG
SDP

WM-1119 is a small-molecule inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) used as a biochemical probe in epigenetics and oncology research. It exhibits potent biochemical activity (KAT6A IC50 = 6.3 nM) and demonstrated cellular activity (EMRK1184 B-cell lymphoma IC50 = 0.25 μM). Key identifiers: CAS 2055397-28-7; formula C18H13F2N3O3S; molecular weight 389.4 g/mol; purity ≥98%.

  • Potent KAT6A inhibition (IC50 = 6.3 nM).
  • Demonstrated cellular activity in lymphoma cells (IC50 = 0.25 μM).
  • High purity supports reproducible biochemical assays (≥98%).
  • Well-defined molecular properties for characterization.
  • Suitable as a research chemical probe in epigenetic studies.

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5

Medchemexpress LLC 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4h-1,2,4-triazol-3-yl] | 935273-79-3 | 99.2% | 493.47 g/mol | C24H24F5N5O | 50 MG
SDP

MK-4101 is a small-molecule Smoothened (SMO) antagonist that inhibits the hedgehog signaling pathway and is provided for research use. It has demonstrated cellular activity in reported assays and is supplied as a solid in multiple pre-weighed quantities.

  • Small-molecule SMO antagonist useful for hedgehog pathway studies.
  • Demonstrated cellular activity (IC50 ≈1.1 μM in 293 cells).
  • Reported cellular activity in mouse cells (IC50 ≈1.5 μM).
  • Supplied with high reported purity (~99.2%) suitable for research.
  • Available in multiple pre-weighed quantities, including 50 mg.
  • Characterized molecular properties (CAS 935273-79-3; formula C24H24F5N5O).

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6

Medchemexpress LLC 5-(3,3-difluorocyclobutyl)-3-(bicyclo[2.2.2]octan-1-yl)-1,2,4-oxadiazole | 935273-79-3 | MFCD30343842 | 99.2% | 493.47 g/mol | C24H24F5N5O | 100 MG
SDP

MK-4101 is a small-molecule Smoothened (SMO) antagonist and hedgehog pathway inhibitor used for research applications, including in vitro pathway studies and preclinical cancer research. It shows antitumor activity by inhibiting tumor cell proliferation and inducing apoptosis.

  • Small-molecule SMO antagonist suitable for in vitro and preclinical studies.
  • High reported purity of 99.16%.
  • Molecular weight 493.47 g/mol and formula C24H24F5N5O.
  • Soluble in DMSO at ≥50 mg/mL; in vivo formulation protocols available.
  • Recommended storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years).
  • Reported cellular potency in the low micromolar range (IC50 values).

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