Alkyl fluorides
Medchemexpress LLC BAY-678 | 675103-36-3 | 99.59% | 400.35 | 50 MG
BAY-678 is an orally bioavailable, highly potent, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. It is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). For research use only; not sold to patients.
- Orally bioavailable
- Highly potent and selective inhibitor of human neutrophil elastase (HNE)
- Cell-permeable
- IC50 of 20 nM (HNE)
- Ki value for MNE is 700 nM
- Fourth-generation HNE inhibitor
- More than 2,000-fold selectivity in a panel of 21 serine proteases
- Reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating anti-inflammatory and anti-remodeling mode of action
- Shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice
eMolecules 307-24-4 | Perfluorohexanoic acid | Combi-Blocks, Inc. | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 100g | 837463435
Perfluorohexanoic acid | Combi-Blocks, Inc. | 307-24-4 | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 100g | 837463435
Medchemexpress LLC Lmp2a (426-434) | 152274-91-4 | 96.1% | 906.16 | 5 MG
LMP2A (426-434) is a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope of Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A). It can trigger an immune response in individuals expressing different HLA-A*02 subtypes (A*02:01, A*02:03, A*02:06, and A*02:07). This peptide induces a strong IFN-γ secretion response, stimulating the production of a high proportion of CD8+ IFN-γ+ T cells. It also induces specific CTLs to effectively kill target cells expressing LMP2A. It is used in the study of EBV-related malignant tumors such as Hodgkin's disease and nasopharyngeal carcinoma.
- Induces IFN-γ secreting cells at a frequency of 80.6 SFC/5x10⁴ CD8+ T cells (at 20 μg/mL for 24 h).
- Significantly increases the proportion of CD8+IFN-γ+ cells (at 20 μg/mL for 2 weeks).
- Specific CTLs effectively kill peptide-pulsed T2 cells and 293T-LMP2A cells (at 20 μg/mL for 4 h).
Medchemexpress LLC Perfluorododecanoic acid | 307-55-1 | MFCD00198081 | 95.0% | 614.10 g·mol⁻¹ | C12HF23O2 | 10 MG
Perfluorododecanoic acid is a perfluoroalkyl carboxylic acid used as a research reagent to investigate PFAS-driven biological effects such as cytotoxicity, increased reactive oxygen species, and altered mitochondrial membrane potential. It is provided as a high-purity solid for laboratory studies.
Medchemexpress LLC GluN1(356-385) | 99.95% | 3415.90 | 1 MG
GluN1 (356-385) is an antigenic peptide developed for the study of N-methyl-D-aspartate receptor (NMDAR) encephalitis. It functions by reducing the density of surface NMDAR clusters in hippocampal neurons, offering a tool to understand the pathogenesis of anti-NMDAR encephalitis.
- Antigenic peptide against NMDAR encephalitis
- Reduces density of surface NMDAR clusters in hippocampal neurons
- Useful for studying anti-NMDAR encephalitis pathogenesis
Cambridge Isotope Laboratories 2H 2H 3H 3H-Perfluorohexanoic acid (3 3 FTCA) (unlabeled) 100 ug/mL in methanol 1 2 mL
2H 2H 3H 3H-Perfluorohexanoic acid (3 3 FTCA) (unlabeled) 100 ug/mL in methanol 1 2 mL
FUJIFILM Biosciences UNDECAFLUOROHEANOIC ACID, 1G
*Orders for this supplier are non-cancellable/non-returnable once they are processed.* Undecafluoroheanoic Acid, 1g. 307-24-4 MFCD00198040
Medchemexpress LLC Perfluoropentanoic acid | 2706-90-3 | 98.0% | 264.05 | 1 G
Perfluoropentanoic acid (PFPeA) is a short-chain perfluorinated compound used as an important indicator of perfluorinated compound pollution in ecosystems. It exhibits certain toxicity to mice and is intended for research use only.
- Short-chain perfluorinated compound.
- Indicator of perfluorinated compound pollution.
- Exhibits toxicity to mice, affecting liver, skin, and immune cells.
- Can impact planktonic microbial communities and water quality.
- Increases serum and urine concentrations after topical application.
- Alters gene expression related to lipid metabolism and inflammation.
Medchemexpress LLC Perfluorodecanoic acid | 335-76-2 | MFCD00004175 | 98.0% | 514.08 g/mol | C10HF19O2 | 100 MG
Perfluorodecanoic acid (PFDA) is a perfluoroalkyl carboxylic acid supplied for laboratory research use and commonly used in studies of PFAS behavior, environmental fate, and toxicology. Documentation including a data sheet, certificate of analysis, and safety data sheet is provided by the manufacturer.
- High purity suitable for analytical and toxicological studies.
- Available in small milligram quantities for laboratory research.
- Documented CAS number and molecular properties for clear identification.
- Provided with data sheet, certificate of analysis, and safety data sheet.
- For research use only; not intended for human or clinical applications.
BIOHIPPO Research Grade Anti-Human CD266/TNFRSF12A Biosimilar Antibody (BAY-356), 100 µg
BAY-356 is a research-grade biosimilar antibody targeting CD266/TNFRSF12A. It reacts with Human. Suitable for ELISA, FACS, Functional assay, Research in vivo. This research-grade biosimilar supports comparability, functional, PK/PD and immunogenicity studies. Supplied as 100 ug.
Medchemexpress LLC Neo 376 | 496921-73-4 | 99.2% | 357.88 | C20H24ClN3O | 5 MG
NEO 376 is a small-molecule research compound described as a selective modulator of 5-HT1 (serotonin), GABA, and dopamine receptors with reported antipsychotic activity. It is intended for pharmacological and neurobiological studies and is provided with analytical documentation to support research use.
- Selective modulator of 5-HT1, GABA, and dopamine receptors.
- Reported antipsychotic activity suitable for psychiatric research.
- High purity: 99.2%.
- Molecular weight 357.88 and formula C20H24ClN3O.
- Soluble in DMSO; available as 10 mM solution or as solid (small pack sizes).
- Supplied with datasheet, certificate of analysis, and safety data sheet for research use.
Proteochem Inc HFBA Ampules (Proteomics Grade), 375-22-4, MFCD00004171, 10x1 mL
MF: C4 H F7 O2, MW: 214.04, Alternative Names: HFBA; Heptafluorobutanoic acid; Perfluorobutanoic acid; Perfluorobutyric acid; 2,2,3,3,4,4,4-Heptafluorobutanoic acid. Heptafluorobutyric Acid (HFBA) is an ion pairing agent for reverse-phase HPLC separation of peptides or proteins.
Cayman Chemical 2H 2H 3H 3H-Perfluorodecanoic
A polyfluoroalkyl substance; has been found as a contaminant in freshwater reserves and marine seafood
Medchemexpress LLC GluN1(356-385) | 99.95% | 3415.90 | 5 MG
GluN1 (356-385) is an antigenic peptide used against N-methyl-D-aspartate receptor (NMDAR) encephalitis. It effectively reduces the density of surface NMDAR clusters in hippocampal neurons. This peptide can be utilized to investigate the pathogenesis of anti-NMDAR encephalitis.
- Antigenic peptide against N-methyl-D-aspartate receptor (NMDAR) encephalitis.
- Reduces the density of surface NMDAR clusters in hippocampal neurons.
- Useful for studying the pathogenesis of anti-NMDAR encephalitis.
- Purity of 99.95%.