Halomethanes
Apexbio Technology LLC 360A iodide 737763-37-0 50mg
360A iodide (CAS 737763-37-0) is a 2 6-pyridine-dicarboxamide derivative that acts as a selective ligand for G-quadruplex DNA structures By stabilizing telomeric G-quadruplexes 360A inhibits telomerase activity and induces alterations in cell cycle progression notably causing S-phase accumulation in ATM-proficient EBV-lymphocytes Its mechanism of action involves promoting sister telomere fusions via DNA-PKcs-dependent non-homologous end joining (NHEJ) as well as triggering NHEJ and homologous recombination (HR) pathways at telomeres which disrupt mitotic progression 360A has been shown to preferentially bind telomeric G-quadruplex DNA over duplex DNA and to delay growth in HT1080 tumor cells This compound is valuable for investigating telomere biology DNA damage response and G-quadruplex-mediated genomic stability
![eMolecules 13237-88-2 | 7-bromobicyclo[2.2.1]heptane | Synthonix175.069 | C7H11Br | 99.000 | BrC1C2CCC1CC2 | 500mg | 784552152](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502464460.JPG-250.jpg)
eMolecules 13237-88-2 | 7-bromobicyclo[2.2.1]heptane | Synthonix175.069 | C7H11Br | 99.000 | BrC1C2CCC1CC2 | 500mg | 784552152
7-bromobicyclo[2.2.1]heptane | Synthonix | 13237-88-2175.069 | C7H11Br | 99.000 | BrC1C2CCC1CC2 | 500mg | 784552152
Medchemexpress LLC 2-cyclohexen-1-one, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl- | 220757-88-0 | 99.1% | 364.60 | C24H44O2 | 10 MG
tCFA15 is a trimethyl cyclohexenonic long-chain fatty alcohol (C24H44O2, MW 364.60) that promotes neuronal differentiation and modulates Notch1 signaling. It is supplied as a high-purity research standard intended for in vitro studies of neural stem cell differentiation and neuronal signaling pathways.
- Promotes differentiation of neural stem cell-derived neurospheres toward neurons.
- Modulates Notch1 expression and signaling.
- High purity suitable for in vitro research applications.
- Soluble in DMSO for solution-based assays.
- Shown to stimulate arginine vasopressin secretion in neurohypophysis preparations.
Medchemexpress LLC (-)-Denudatin B | 87402-88-8 | 1 MG
Denudatin B is an antiplatelet agent that relaxes vascular smooth muscle. It functions by inhibiting calcium ion influx through voltage-gated and receptor-operated calcium channels, and also exhibits a nonspecific antiplatelet action. This compound is provided with a purity of 97.88%.
- Acts as an antiplatelet agent
- Relaxes vascular smooth muscle
- Inhibits calcium ion influx through voltage-gated and receptor-operated calcium channels
- Exhibits nonspecific antiplatelet action
- Stored at 4°C, sealed, away from moisture and light
- In solvent, stored at -80°C for 6 months or -20°C for 1 month
eMolecules 76903-88-3 | Ambeed | 34-difluorobenzoylchloride | 5g | 569096044 | A378696 | MFCD00009930 | 176.55 | C7H3ClF2O
Ambeed | 34-difluorobenzoylchloride | 5g | 569096044 | A378696 | 76903-88-3 | MFCD00009930 | 176.550 | C7H3ClF2O
Medchemexpress LLC CCL4 Human 2ug
CCL4 Protein Human is a small cytokine of the CC chemokine subfamily that binds to the CCR5 chemokine receptor on the cell surface promotes leukocyte aggregation under various inflammatory conditions and contributes to immune protection against human immunodeficiency virus type 1 CCL4 Protein Human is a recombinant human CCL4 (A24-N92) expressed by E coli[1]
eMolecules 75-11-6 | Diiodomethane | Combi-Blocks | MFCD00001079 | 267.836 | CH2I2 | 98.000 | ICI | 5g | 537622802
Diiodomethane | Combi-Blocks | 75-11-6 | MFCD00001079 | 267.836 | CH2I2 | 98.000 | ICI | 5g | 537622802
Medchemexpress LLC Bay-593 | 2413020-56-9 | 99.9% | 476.53 | 1 ML
BAY-593 is an orally active GGTase-I inhibitor. It can block YAP1/TAZ signaling in animals and has antitumor activity. It is for research use only and not sold to patients.
- Orally active GGTase-I inhibitor
- Blocks YAP1/TAZ signaling in animals
- Exhibits antitumor activity
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC RN-1665 | 1803003-65-7 | 99.93% | 513.54 | 100 MG
RN-1665 is an orally active TRPV4 antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3, and TRPM8. It serves as a TRPV4 probe for focused screens, showing IC50s of 0.26 μM for human TRPV4 and 0.39 μM for rat TRPV4.
- Orally active.
- TRPV4 antagonist.
- Exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3, and TRPM8.
- Functions as a TRPV4 probe for focus screens.
- Has an IC50 of 0.26 μM for human TRPV4.
- Has an IC50 of 0.39 μM for rat TRPV4.
![eMolecules 112892-88-3 | ChemScene | Bicyclo[4.2.0]octa-135-triene-3-carbaldehyde | 250mg | 632277807 | CS-0044063 | MFCD09842341 | 132.162 | C9H8O](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502442815.PNG-250.jpg)
eMolecules 112892-88-3 | ChemScene | Bicyclo[4.2.0]octa-135-triene-3-carbaldehyde | 250mg | 632277807 | CS-0044063 | MFCD09842341 | 132.162 | C9H8O
Ambeed | 4-Methoxy-2-(4455-tetramethyl-132-dioxaborolan-2-yl)benzaldehyde | 100mg | 789350278 | A797455 | 1196474-59-5 | MFCD16658743 | 262.110 | C14H19BO4
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eMolecules 558-13-4 | Carbon tetrabromide, 98% (dry wt.), may cont. up to ca 6% water | Oakwood Chemicals | MFCD00000117 | 331.627 | CBr4 | 99.000 | BrC(Br)(Br)Br | 1kg | 480144350
Carbon tetrabromide, 98% (dry wt.), may cont. up to ca 6% water | Oakwood Chemicals | 558-13-4 | MFCD00000117 | 331.627 | CBr4 | 99.000 | BrC(Br)(Br)Br | 1kg | 480144350
Cambridge Isotope Laboratories Chloroiodomethane (D2 98%) copper 1 g
Chloroiodomethane (D2 98%) copper 1 g
Sigma Aldrich Fine Chemicals Biosciences Dibromomethane-d2 >=99 atom % D, >=99% (CP), contains copper as stabilizer | 22117-86-8 | MFCD00000169 | 5G
Dibromomethane-d2 >=99 atom % D, >=99% (CP), contains copper as stabilizer | Purity: >=99% (CP) | Mol Wt: 175.85 | 22117-86-8 | MFCD00000169 | 5G
TARGETMOL CHEMICALS INC MPP iodide 50MG
Also available in 1 g, 1 mL, 5 mg, 10 mg, 25 mg, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells. Purity 99.96%