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Filtered Search Results
Medchemexpress LLC Benactyzine hydrochloride | 57-37-4 | 99.0% | 1 ML
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Benactyzine hydrochloride is a competitive BChE inhibitor with a Ki of 0.01 mM. It is an anticholinergic drug and has potential for organophosphate poisoning research.
- Competitive BChE inhibitor
- Anticholinergic properties
- Potential for organophosphate poisoning research
- High purity of 99.0%
- Available in various formulations
- Optimized for stability with specific storage conditions
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC C13H9N5O5S2 | 883065-90-5 | MFCD01313575 | 99.9% | 379.37 g/mol | C13H9N5O5S2 | 100 MG
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BI-78D3 is a small-molecule substrate-competitive inhibitor of c-Jun N-terminal kinases (JNK) used as a research tool to probe JNK-dependent signaling. It inhibits JNK kinase activity with a reported IC50 of 280 nM and is supplied for in vitro research use only.
- Substrate-competitive JNK inhibitor (IC50 = 280 nM).
- Molecular formula C13H9N5O5S2; molecular weight 379.37 g/mol.
- High purity (99.85%) suitable for biochemical and cell-based assays.
- Soluble in DMSO; handle using standard laboratory safety procedures.
- For research use only; not for human or veterinary applications.
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Medchemexpress LLC Naphthol AS-TR phosphate disodium | 4264-93-1 | MFCD00069550 | 99.9% | C18H13ClNNa2O5P | 10MG
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Naphthol AS-TR phosphate disodium is a water-soluble enzymatic substrate used to detect alkaline phosphatase activity. The disodium salt is hydrolyzed by phosphatases to form a colored product that is measurable spectrophotometrically, making it suitable for biochemical assays, histochemical staining, and enzyme activity monitoring in biological samples.
- Water-soluble disodium salt suitable for aqueous assays.
- Sensitive substrate for alkaline and acid phosphatases.
- Generates a colored product upon enzymatic hydrolysis for spectrophotometric detection.
- High purity for reproducible assay results.
- Available in small pack sizes for laboratory-scale use.
- Stable solid form for storage and handling.
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Medchemexpress LLC 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one | 1883429-21-7 | 100.0% | 353.41 Da | C20H23N3O3 | 50 MG
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BI-7273 is a selective, cell-permeable bromodomain inhibitor used as a research tool to probe BRD9 and BRD7 biology. It demonstrates potent biochemical activity and is provided as a powdered reagent for laboratory assays.
- Selective, cell-permeable inhibitor of BRD9 and BRD7.
- Potent biochemical activity: IC50 19 nM (BRD9) and 117 nM (BRD7).
- Characterized compound: CAS 1883429-21-7; formula C20H23N3O3.
- Supplied as a powder suitable for in vitro and in vivo research.
- High purity appropriate for biochemical and cellular studies.
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Medchemexpress LLC Bi 01383298 | 2227549-00-8 | 99.3% | 445.34 | C19H19Cl2FN2O3S | 10MG
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BI01383298 is a small-molecule chemical probe that potently and selectively inhibits the sodium-coupled citrate transporter SLC13A5 (hNaCT). It is used in research to probe citrate transport and SLC13A5 function in human cells and preclinical studies.
- Potent inhibitor of SLC13A5: IC50 = 56 nM (hSLC13A5 in HEK cells) and 24 nM (HepG2).
- Highly selective: negligible activity on other SLC13 family members and murine SLC13A5 (IC50 >100 μM).
- High purity suitable for research use: 99.3% (HPLC).
- Molecular formula C19H19Cl2FN2O3S; molecular weight 445.34 g/mol.
- Provided as a small-quantity research solid for in vitro and preclinical applications.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Thiobis-β-galactose-propyne | 1989627-40-8 | 98.0% | C27H40O12S2 | 10MG
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Thiobis-β-galactose-propyne is a thiobis-linked galactose derivative used as a multivalent galectin inhibitor in preclinical research. It is supplied as a solid and intended for biochemical and cell-based studies investigating galectin-mediated interactions.
- Multivalent galectin inhibitor suitable for biochemical assays.
- Contains a propyne functional group for click-chemistry conjugation.
- Reported high purity appropriate for in vitro applications.
- Supplied as a solid and stable under recommended frozen storage.
- Available in small mass vials convenient for screening and conjugation work.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Dibenamine hydrochloride (N-(2-Chloroethyl)dibenzylamine hydrochloride) | 55-43-6 | 99.3% | 1 ML
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Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent. It is known for its ability to modify the pharmacological effects of epinephrine and significantly increases the rate of I-epinephrine destruction. In vitro, Dibenamine has been shown to attenuate cocaine-induced increases in sensitivity to acetylcholine in isolated guinea pig vas deferens. In vivo, it has been observed to reduce CHCl3 levels by 30-50 percent, suggesting it slows the conversion of CCl4 to CHCl3.
- Acts as a competitive and irreversible adrenergic blocking agent
- Modifies pharmacological effects of epinephrine
- Increases rate of I-epinephrine destruction
- Attenuates cocaine-induced increases in sensitivity to acetylcholine in guinea pig vas deferens
- Reduces CHCl3 levels, slowing CCl4 to CHCl3 conversion
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Medchemexpress LLC BI-3812 | 2166387-64-8 | 99.3% | 558.03 | 100 MG
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BI-3812 is a chemical probe and a highly efficient BCL6 inhibitor. It suppresses the BTB domain of BCL6 with an IC50 value of ≤ 3 nM, demonstrating antitumor activity. This product is intended for research use only and not for patient use.
- Highly efficient BCL6 inhibitor
- Suppresses the BTB domain of BCL6 with an IC50 value of ≤ 3 nM
- Exhibits antitumor activity
- Cellular BCL6 IC50 of 40 nM
- Available as a chemical probe
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Blu-945 | 2660250-10-0 | 99.6% | C28H37FN6O3S | 1 ML
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BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKIs). It effectively inhibits EGFR with L858R and/or exon 19 deletion mutation, T790M mutation, and C797S mutation, making it suitable for lung cancer research, including non-small cell lung cancer (NSCLC).
- Potent, highly selective, reversible, and orally active
- Inhibits EGFR with L858R, exon 19 deletion, T790M, and C797S mutations
- Used for research of lung cancer, including non-small cell lung cancer (NSCLC)
- Demonstrates anti-tumor activity in triple-mutant Osimertinib-resistant models
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eMolecules 13826-27-2 | 2,2'-Bi-1,3,2-benzodioxaborole | Accela ChemBio (ASD) | MFCD09842343 | 237.810 | C12H8B2O4 | 95.000 | O1B(Oc2ccccc12)B1Oc2ccccc2O1 | 25g | 517258233
2,2'-Bi-1,3,2-benzodioxaborole | Accela ChemBio (ASD) | 13826-27-2 | MFCD09842343 | 237.810 | C12H8B2O4 | 95.000 | O1B(Oc2ccccc12)B1Oc2ccccc2O1 | 25g | 517258233
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 312692-97-0 | 3,4-Dimethylphenylzinc iodide, 0.50 M in THF | Synthonix | MFCD01311451 | 297.440 | C8H9IZn | 0.000 | [I-].Cc1ccc([Zn+])cc1C | 50ml | 532652778
3,4-Dimethylphenylzinc iodide, 0.50 M in THF | Synthonix | 312692-97-0 | MFCD01311451 | 297.440 | C8H9IZn | 0.000 | [I-].Cc1ccc([Zn+])cc1C | 50ml | 532652778
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 33974-41-3 | Neopentylmagnesium bromide, 1.0 M in THF | Synthonix175.352 | C5H11BrMg | 0.000 | [Br-].CC(C)(C)C[Mg+] | 100ml | 702445966
Neopentylmagnesium bromide, 1.0 M in THF | Synthonix | 33974-41-3175.352 | C5H11BrMg | 0.000 | [Br-].CC(C)(C)C[Mg+] | 100ml | 702445966
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 138084-62-5 | [3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopent-1-yl)propyl]magnesium bromide, 0.5M in THF | Synthonix304.661 | C9H22BrMgNSi2 | 95.000 | [Br-].C[Si]1(C)CC[Si](C)(C)N1CCC[Mg+] | 50ml | 794559325
[3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopent-1-yl)propyl]magnesium bromide, 0.5M in THF | Synthonix | 138084-62-5304.661 | C9H22BrMgNSi2 | 95.000 | [Br-].C[Si]1(C)CC[Si](C)(C)N1CCC[Mg+] | 50ml | 794559325
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eMolecules 307496-28-2 | 3-Fluorophenylzinc iodide, 0.50 M in THF | Synthonix | MFCD01311395 | 287.380 | C6H4FIZn | 0.000 | [I-].Fc1cccc([Zn+])c1 | 25ml | 627353646
3-Fluorophenylzinc iodide, 0.50 M in THF | Synthonix | 307496-28-2 | MFCD01311395 | 287.380 | C6H4FIZn | 0.000 | [I-].Fc1cccc([Zn+])c1 | 25ml | 627353646
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Medchemexpress LLC Bi-4020 | 2664214-60-0 | 99.30% | 100 MG
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BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. It inhibits the triple mutant EGFR del19 T790M C797S variant with an IC50 of 0.2 nM in BaF3 cell lines, as well as the double mutant EGFR del19 T790M and primary mutant EGFR del19 with an IC50 of 1 nM. It also shows activity against EGFR wt (IC50=190 nM).
- Inhibits triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines)
- Inhibits double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM)
- Shows activity against EGFR wt (IC50=190 nM)
- Exhibits high kinome selectivity
- Good DMPK properties
- Leads to tumor regressions in human PC-9 (EGFR del19 T790M C797S) triple mutant NSCLC xenograft model in mice
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