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Filtered Search Results
Apexbio Technology LLC BI-847325 1207293-36-4 100mg
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BI-847325 (CAS 1207293-36-4) is a dual inhibitor targeting MEK1/2 and Aurora kinases with reported IC50 values of 25 nM and 4 nM against MEK1 and MEK2 and 3 nM 25 nM and 15 nM against Aurora A B and C respectively By inhibiting these kinases BI-847325 disrupts the MAPK/ERK and cell cycle signaling pathways that regulate cell proliferation and survival In cellular assays it demonstrates nanomolar EC50 values for inhibition of pERK and pHH3 in KRAS- and BRAF-mutant cancer cell lines and potently suppresses proliferation across a wide range of tumor cell models In xenograft studies it fully blocks tumor growth in BRAF- and KRAS-mutant cancer models This compound is utilized in research on kinase-targeted cancer therapies
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![eMolecules Synthonix - Stock / 2-[(Tributylstannyl)methyl]-1H-isoindole-13(2H)-dione / 250mg / 525905195 / A1306 / / 144157-84-6 / [null] / 450.210 / C21H33NO2Sn](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502456629.PNG-250.jpg)
eMolecules Synthonix - Stock / 2-[(Tributylstannyl)methyl]-1H-isoindole-13(2H)-dione / 250mg / 525905195 / A1306 / / 144157-84-6 / [null] / 450.210 / C21H33NO2Sn
Synthonix - Stock / 2-[(Tributylstannyl)methyl]-1H-isoindole-13(2H)-dione / 250mg / 525905195 / A1306 / / 144157-84-6 / [null] / 450.210 / C21H33NO2Sn
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![eMolecules 497923-83-8 | 2-Chloro-4-fluorophenylzinc iodide, 0.50 M in THF | Synthonix | MFCD02260160 | 321.820 | C6H3ClFIZn | 0.000 | [I-].Fc1ccc([Zn+])c(Cl)c1 | 25ml | 627353544](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502695416.jpg-250.jpg)
eMolecules 497923-83-8 | 2-Chloro-4-fluorophenylzinc iodide, 0.50 M in THF | Synthonix | MFCD02260160 | 321.820 | C6H3ClFIZn | 0.000 | [I-].Fc1ccc([Zn+])c(Cl)c1 | 25ml | 627353544
2-Chloro-4-fluorophenylzinc iodide, 0.50 M in THF | Synthonix | 497923-83-8 | MFCD02260160 | 321.820 | C6H3ClFIZn | 0.000 | [I-].Fc1ccc([Zn+])c(Cl)c1 | 25ml | 627353544
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Medchemexpress LLC 4-Chloro-1-naphthol | 604-44-4 | 178.62 | 1 ML
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4-Chloro-1-naphthol is a substrate of horseradish peroxidase. It can be used to visualize protein bands in western blotting and immunohistochemical staining, and also as a substrate to stain cryosections black by indirect immunoperoxidase staining.
- Functions as a substrate for horseradish peroxidase
- Useful for visualizing protein bands in western blotting
- Applicable in immunohistochemical staining
- Can be used to stain cryosections black via indirect immunoperoxidase staining
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eMolecules 2987-06-6 | 4-(Benzyloxy)cyclohexanone | ChemScene | MFCD10697867 | 204.269 | C13H16O2 | 96.000 | O=C1CCC(CC1)OCc1ccccc1 | 25g | 582638620
4-(Benzyloxy)cyclohexanone | ChemScene | 2987-06-6 | MFCD10697867 | 204.269 | C13H16O2 | 96.000 | O=C1CCC(CC1)OCc1ccccc1 | 25g | 582638620
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eMolecules Synthonix 2-(Tributylstannyl)oxazole 250mg 659071661 T5598 145214-05-7 MFCD06798076 358.113 C15H29NOSn
Synthonix 2-(Tributylstannyl)oxazole 250mg 659071661 T5598 145214-05-7 MFCD06798076 358.113 C15H29NOSn
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![eMolecules Synthonix 3-(Methoxycarbonyl)phenylzinc iodide 0.50 M in THF 100ml 532652899 M73174 148651-38-1 [null] 327.430 C8H7IO2Zn](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502696094.jpg-250.jpg)
eMolecules Synthonix 3-(Methoxycarbonyl)phenylzinc iodide 0.50 M in THF 100ml 532652899 M73174 148651-38-1 [null] 327.430 C8H7IO2Zn
Synthonix 3-(Methoxycarbonyl)phenylzinc iodide 0.50 M in THF 100ml 532652899 M73174 148651-38-1 [null] 327.430 C8H7IO2Zn
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![eMolecules 935433-87-7 | 5-Fluoro-2-pyridylzinc bromide, 0.50 M in THF | Synthonix241.370 | C5H3BrFNZn | 0.000 | [Br-].Fc1ccc([Zn+])nc1 | 25ml | 627353652](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502695318.jpg-250.jpg)
eMolecules 935433-87-7 | 5-Fluoro-2-pyridylzinc bromide, 0.50 M in THF | Synthonix241.370 | C5H3BrFNZn | 0.000 | [Br-].Fc1ccc([Zn+])nc1 | 25ml | 627353652
5-Fluoro-2-pyridylzinc bromide, 0.50 M in THF | Synthonix | 935433-87-7241.370 | C5H3BrFNZn | 0.000 | [Br-].Fc1ccc([Zn+])nc1 | 25ml | 627353652
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eMolecules 38952-61-3 | N,N-Dimethylmorpholine-4-carboxamide | Combi-Blocks | MFCD02859873 | 158.201 | C7H14N2O2 | 98.000 | CN(C)C(=O)N1CCOCC1 | 1g | 517093100
N,N-Dimethylmorpholine-4-carboxamide | Combi-Blocks | 38952-61-3 | MFCD02859873 | 158.201 | C7H14N2O2 | 98.000 | CN(C)C(=O)N1CCOCC1 | 1g | 517093100
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![eMolecules 41242-25-5 | 2,3,4,5,6-Pentafluorophenylzinc bromide, 0.50 M in THF | Synthonix312.340 | C6BrF5Zn | 97.000 | [Br-].Fc1c(F)c(F)c([Zn+])c(F)c1F | 25ml | 795399116](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502694589.jpg-250.jpg)
eMolecules 41242-25-5 | 2,3,4,5,6-Pentafluorophenylzinc bromide, 0.50 M in THF | Synthonix312.340 | C6BrF5Zn | 97.000 | [Br-].Fc1c(F)c(F)c([Zn+])c(F)c1F | 25ml | 795399116
2,3,4,5,6-Pentafluorophenylzinc bromide, 0.50 M in THF | Synthonix | 41242-25-5312.340 | C6BrF5Zn | 97.000 | [Br-].Fc1c(F)c(F)c([Zn+])c(F)c1F | 25ml | 795399116
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Medchemexpress LLC Encenicline hydrochloride | 550999-74-1 | C16H18Cl2N2OS | 100 MG
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Encenicline hydrochloride is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). This compound is intended for research use only and is not sold to patients. It demonstrates selectivity for α7 nAChRs and has shown promising results in restoring memory function in preclinical studies.
- Novel partial agonist of α7 neuronal nicotinic acetylcholine receptors
- Purity of 98.01%
- White to off-white solid appearance
- Exhibits good brain penetration
- Restores memory function in scopolamine-treated rats
- Moderately binds to rat plasma proteins
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(CCCC)c1ccnn1C | 10g | 525921666](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502696639.jpg-250.jpg)
eMolecules 170682-50-5 | 1-Methyl-5-(tributylstannyl)-1H-pyrazole | Synthonix - Stock | MFCD19686983 | 371.156 | C16H32N2Sn | 95.000 | CCCC[Sn](CCCC)(CCCC)c1ccnn1C | 10g | 525921666
1-Methyl-5-(tributylstannyl)-1H-pyrazole | Synthonix - Stock | 170682-50-5 | MFCD19686983 | 371.156 | C16H32N2Sn | 95.000 | CCCC[Sn](CCCC)(CCCC)c1ccnn1C | 10g | 525921666
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![eMolecules 1213256-49-5 | 4-Chloro-2-methoxyphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | MFCD11553187 | 245.780 | C7H6BrClMgO | 0.000 | [Br-].COc1cc(Cl)ccc1[Mg+] | 25ml | 437237052](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502697733.jpg-250.jpg)
eMolecules 1213256-49-5 | 4-Chloro-2-methoxyphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | MFCD11553187 | 245.780 | C7H6BrClMgO | 0.000 | [Br-].COc1cc(Cl)ccc1[Mg+] | 25ml | 437237052
4-Chloro-2-methoxyphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | 1213256-49-5 | MFCD11553187 | 245.780 | C7H6BrClMgO | 0.000 | [Br-].COc1cc(Cl)ccc1[Mg+] | 25ml | 437237052
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Medchemexpress LLC Ganfeborole hydrochl 100mg | 2131798-13-3 | 100MG
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Ganfeborole hydrochloride (GSK656) is a potent antitubercular agent acting as an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS) with an IC50 of 0 2 M
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Medchemexpress LLC Anagrelide hydrochloride | 58579-51-4 | MFCD01720337 | 99.4% | 1 ML
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Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) that inhibits platelet aggregation and bone marrow megakaryocytopoiesis. It has been shown to decrease gastrointestinal stromal tumor (GIST) cell proliferation and promote apoptosis in vitro. This imidazoquinazoline derivative acts as a platelet-lowering agent and exhibits antithrombopoietic action.
- Potent inhibitor of phosphodiesterase type III (PDE3) with an IC50 of 36 nM.
- Inhibits platelet aggregation.
- Inhibits bone marrow megakaryocytopoiesis.
- Decreases gastrointestinal stromal tumor (GIST) cell proliferation.
- Promotes apoptosis in vitro.
- Potently inhibits the development of marrow megakaryocytes (IC50=26 nM).
- Induces a cytotoxic effect in the GIST882 cell line (IC50=16 nM).
- Inhibits or reduces tumor growth in GIST2B, GIST9, and GIST882 models in vivo.
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