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Polycyclic aromatic hydrocarbon compounds that consist of ten carbon atoms and eight hydrogen atoms fused into two benzene rings; it is the simplest polycyclic aromatic hydrocarbon.
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Tamsulosin hydrochloride is an orally active antagonist of the α1-adrenergic receptor. It induces apoptosis and is used for research related to prostatic hyperplasia. It also attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models.
Orally active α1-adrenergic receptor antagonist
Induces apoptosis
Used for research of prostatic hyperplasia
Attenuates abdominal aortic aneurysm growth
Inhibits inflammation in animal models
Stable under recommended storage conditions
White to off-white solid appearance
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Tamsulosin hydrochloride is an orally active antagonist of the α1-adrenergic receptor. It induces apoptosis and is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride also attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models.
Orally active α1-adrenergic receptor antagonist
Induces apoptosis
Used for prostatic hyperplasia research
Attenuates abdominal aortic aneurysm growth
Inhibits inflammation in animal models
Molecular weight: 444.97
Chemical formula: C20H29ClN2O5S
Appearance: Solid
Color: White to off-white
Recommended storage: 4°C, sealed, away from moisture and light
Solvent storage: -80°C for 6 months; -20°C for 1 month (sealed, away from moisture and light)
Solubility in DMSO: 50 mg/mL (112.37 mM)
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Tamsulosin hydrochloride is an orally active antagonist of the α1-adrenergic receptor. It is used in the research of prostatic hyperplasia and has been shown to induce apoptosis and attenuate abdominal aortic aneurysm growth and inflammation in animal models.
Exhibits intrinsic activity at human alpha1B adrenergic receptor (EC50 of 0.13 nM).
Attenuates high glucose-induced injury in human glomerular endothelial cells.
Influences ECM production and distribution, and cellular metabolism levels in ARPE 19 cells.
Induces apoptosis and clusterin expression in NRP-152 cells.
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Chemical. CAS 18228-17-6. Formula C17H13ClNO5P. MW 377.72. Synthetic. Histochemical substrate for alkaline phosphatases. Aldolase inhibitor. Small molecule inhibitor. Anticancer compound that directly targets the KIX domain of CBP, resulting in a disrupted CREB-CBP complex, inhibited CREB-target gene induction and inhibited IL-1beta-mediated angiogenic activity in cancer cell lines. Inhibits activity of transcription factor Myb by blocking interaction with KIX domain of coactivator p300 in human leukemia cells. Interferes with the Myb–KIX interaction in vitro and inhibits Myb activity in vivo. Suppresses the expression of Myb target genes and induces myeloid differentiation and apoptosis.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Chemical. CAS 18228-17-6. Formula C17H13ClNO5P. MW 377.72. Synthetic. Histochemical substrate for alkaline phosphatases. Aldolase inhibitor. Small molecule inhibitor. Anticancer compound that directly targets the KIX domain of CBP, resulting in a disrupted CREB-CBP complex, inhibited CREB-target gene induction and inhibited IL-1beta-mediated angiogenic activity in cancer cell lines. Inhibits activity of transcription factor Myb by blocking interaction with KIX domain of coactivator p300 in human leukemia cells. Interferes with the Myb–KIX interaction in vitro and inhibits Myb activity in vivo. Suppresses the expression of Myb target genes and induces myeloid differentiation and apoptosis.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More