Phenanthrenes and derivatives
Medchemexpress LLC Vardenafil hydrochloride trihydrate | 330808-88-3 | 99.7% | 200 MG
Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM. It shows inhibitory effects towards PDE1 and PDE6 with IC50s of 180 nM and 11 nM, respectively, while IC50s are >1000 nM for PDE3 and PDE4. It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis, which increases cGMP levels. It can be used for research related to erectile dysfunction, hepatitis, and diabetes.
- It is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5).
- It has an IC50 of 0.7 nM for PDE5.
- It inhibits PDE1 and PDE6 with IC50s of 180 nM and 11 nM.
- It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis.
- It increases cGMP levels.
- It can be used for the research of erectile dysfunction.
- It can be used for the research of hepatitis.
- It can be used for the research of diabetes.
Medchemexpress LLC Vardenafil hydrochloride | 224785-91-5 | 99.8% | 200 MG
Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM, showing lower inhibition of PDE1, PDE6, PDE3, and PDE4. It competitively inhibits cGMP hydrolysis, leading to increased cGMP levels. It is used for research of erectile dysfunction, hepatitis, and diabetes.
- Specifically inhibits cGMP hydrolysis by PDE5, increasing intracellular cGMP levels for increased dilation and blood flow.
- Exhibits facilitator effects in rats with cavernous nerve injury.
- Protects the liver against Con A-induced hepatitis in mice and decreases NF-κB expression.
- Prevents reduction of tissue cGMP levels and increased 3-NT generation in ZDF hearts.
Apexbio Technology LLC IM-12 1129669-05-1 200mg
IM-12 (CAS 1129669-05-1) is a small-molecule inhibitor targeting glycogen synthase kinase-3 (GSK-3 ) displaying an IC50 of 53 nM GSK-3 is a serine/threonine kinase involved in neuronal development energy metabolism and Wnt/ -catenin signaling In ReNcell VM cells IM-12 inhibits GSK-3 resulting in increased -catenin accumulation enhanced TCF transcriptional activity and elevated neuronal differentiation markers The compound also extends cell doubling time and suppresses proliferation These properties make IM-12 valuable for investigating GSK-3 signaling in neurobiology cell proliferation and differentiation studies
Medchemexpress LLC SKF 38393 hydrochloride | 62717-42-4 | MFCD00069248 | >98.0% | 291.77 g/mol | C16H18ClNO2 | 200MG
SKF 38393 hydrochloride is the hydrochloride salt of SKF-38393, a selective dopamine D1 receptor agonist with a reported IC50 of approximately 110 nM. Supplied as a research-grade solid analytical standard, it is used for in vitro pharmacology, receptor binding, and analytical assays. Not for human or clinical use.
- Selective D1 receptor agonist, reported IC50 ≈ 110 nM.
- Hydrochloride salt form improves solubility for biological assays.
- Molecular weight 291.77 g/mol.
- Chemical formula C16H18ClNO2.
- Provided as a solid analytical standard suitable for in vitro studies.
- Typical purities reported ≥98% by HPLC from third-party suppliers.
- Not for human or clinical use; for research only.
![eMolecules ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475670.JPG-250.jpg)
eMolecules ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6
ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6
Medchemexpress LLC Fullerene-C60 | 99685-96-8 | MFCD00151408 | 99.7% | 720.64 g/mol | C60 | 50 MG
Fullerene-C60 is a buckminsterfullerene (C60) molecular carbon compound supplied as a brown to black solid for biochemical and analytical research. It has molecular weight 720.64 g/mol and CAS 99685-96-8, and is provided at high purity for experimental use.
- High purity: 99.73%.
- Molecular formula: C60; molecular weight 720.64 g/mol.
- Physical form: brown to black solid powder.
- Low solubility: H2O < 0.1 mg/mL; DMSO < 1 mg/mL.
- Recommended storage: powder at -20°C (3 years) or 4°C (2 years).
- Suitable for biochemical assays and analytical studies.
Medchemexpress LLC 2H-1-benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-, (3R,4S)-rel- | 1213777-80-0 | 99.9% | C22H20O4 | 10MG
Triphen diol is a phenol diol derivative reported to have anticancer activity against pancreatic cancer and cholangiocarcinoma. It induces apoptosis through caspase-mediated and caspase-independent mechanisms and is supplied as a high-purity research reagent for laboratory studies.
- Phenol diol derivative with reported anticancer activity.
- Induces apoptosis via caspase-mediated and caspase-independent pathways.
- High purity (~99.9%) suitable for research applications.
- Molecular formula C22H20O4; molecular weight 348.39 g·mol⁻¹.
- Soluble in DMSO (≈100 mg/mL); use freshly opened solvent to ensure solubility.
- Store protected from light; in solvent store short-term at -20°C and long-term at -80°C.
Apexbio Technology LLC Malonic acid 141-82-2 500mg
Malonic acid is a small-molecule dicarboxylic acid It is commonly used to facilitate the cross-linking of polysaccharide molecules such as corn starch and potato starch by forming covalent linkages via its two carboxyl groups Malonic acid acts primarily through condensation or esterification reactions to increase intermolecular connectivity and modulate the mechanical properties of biopolymer matrices Based on these properties malonic acid holds research potential in pharmaceutical excipient formulation drug delivery system development and biomaterial engineering studies
![eMolecules Chloro[tri(p-tolyl)phosphine]gold(I) | 28978-10-1 | MFCD15144864 | 100mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502137649.JPG-250.jpg)
eMolecules Chloro[tri(p-tolyl)phosphine]gold(I) | 28978-10-1 | MFCD15144864 | 100mg
Ambeed | Chloro[tri(p-tolyl)phosphine]gold(I) | 100mg | 528956050 | A474775 | | 28978-10-1 | MFCD15144864 | 536.790 | C21H21AuClP
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Apexbio Technology LLC Caffeic acid 331-39-5 200mg
Caffeic acid (CAS 331-39-5) is a naturally occurring hydroxycinnamic acid extracted from plant sources such as Solidago decurrens and large-fruited Chinese hawthorn This small molecule is known for its antioxidant activity primarily through the scavenging of reactive oxygen species and inhibition of lipid peroxidation Caffeic acid has also been reported to modulate various cellular signaling pathways including those related to inflammation and apoptosis Due to its bioactive properties caffeic acid is widely utilized in biomedical research to investigate mechanisms of oxidative stress inflammation and associated cellular events It is soluble in hot water and cold ethanol and should be stored sealed in cool dry conditions
Medchemexpress LLC Pazopanib hydrochloride | 635702-64-6 | 100.0% | 200 MG
Pazopanib hydrochloride is the hydrochloride salt of pazopanib, provided as a high-purity analytical standard intended for research and analytical applications (not for human use).
- High purity confirmed by LCMS (99.99%).
- Hydrochloride salt form for consistent analytical performance.
- Molecular formula C21H24ClN7O2S, molecular weight 473.98 g/mol.
- Available in small-scale packages suitable for assay and method development.
- Suitable as a reference standard for LC/MS, HPLC, and biochemical assays.
Medchemexpress LLC 6-Aminochrysene | 2642-98-0 | MFCD00003699 | 99.7% | 243.30 g/mol | C18H13N | 100 MG
6-Aminochrysene is an aromatic amine used in biochemical and toxicological research. The compound is supplied as a high-purity solid or as DMSO solutions for laboratory assays and analytical studies.
- High purity of 99.7% for accurate analytical results.
- Molecular formula C18H13N and molecular weight 243.30 g/mol.
- Available in small research quantities, including 100 mg and solution formats.
- Applicable to enzymatic metabolism, mutagenicity, and toxicology studies.
- Provided with purity and identity information appropriate for research use.
Medchemexpress LLC Aristolochic acid D | 17413-38-6 | 357.27 | 5 MG
Aristolochic acid D | 17413-38-6 | 357.27 | 5 MG
Cayman Chemical ArIstolochIc AcId 50mg
A PLA2 inhibitor (IC50 = 40 µM in human neutrophils); inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo; inhibits hemolytic activity of the PLA2 enzymes TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively); enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib; associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas
eMolecules Medchem Express / Aristolochic acid B / 1mg / 527573755 / HY-N0511 / / 475-80-9 / MFCD01708574 / 311.249 / C16H9NO6
Medchem Express / Aristolochic acid B / 1mg / 527573755 / HY-N0511 / / 475-80-9 / MFCD01708574 / 311.249 / C16H9NO6