Unsubstituted Phenols
Medchemexpress LLC Cl2a-sn-38 | 1279680-68-0 | 1480.61 | C73H97N11O22 | 50 MG
CL2A-SN-38 is a drug-linker conjugate composed of the DNA topoisomerase I inhibitor SN-38 linked via a hydrolyzable CL2A linker, intended for antibody-drug conjugate (ADC) research and development. It releases active SN-38 within tumor cells and the tumor microenvironment, producing bystander antitumor effects.
- Drug-linker conjugate designed for ADC development.
- Releases SN-38 within tumor cells and tumor microenvironment.
- Camptothecin-class topoisomerase I inhibitor mechanism.
- Molecular formula C73H97N11O22; molecular weight 1480.61.
- Soluble in DMSO (100 mg/mL) and in documented in vivo formulations.
- Store at -20°C under nitrogen; in solution -80°C (6 months) or -20°C (1 month).
Selleck Chemical LLC LY2510924
LY2510924 is a potent and selective CXCR4 antagonist that specifically blocks SDF-1 binding to CXCR4 with IC50 value of 0 079 nmol/L and inhibits SDF-1-induced GTP binding with Kb value of 0 38 nmol/L
Apexbio Technology LLC L-690,330 142523-38-4 10mg
L-690 330 (CAS 142523-38-4) is a competitive inhibitor of inositol monophosphatase (IMPase) exhibiting a Ki between 0 2 and 2 M depending on the enzyme source IMPase catalyzes the hydrolysis of inositol monophosphates yielding free inositol for phosphatidylinositol (PI) cycle signaling In M1 CHO cells L-690 330 did not elevate [3H]InsP1 levels alone but attenuated carbachol-stimulated increases producing effects up to 40% of those observed with lithium In vivo L-690 330 administration led to significant Ins(1)P accumulation in mouse brain following muscarinic agonist stimulation These properties make L-690 330 a valuable tool for probing inositol signaling pathways and studying IMPase-related neurological processes