Azobenzenes
Medchemexpress LLC Iclepertin | 1421936-85-7 | 99.9% | 512.42 | 100 MG
Iclepertin is a potent, selective, and orally active glycine transporter 1 (GlyT1) inhibitor. It is inactive against GlyT2 and can be used for Alzheimer's disease and schizophrenia research.
- Appearance: Solid, white to off-white
- Inhibits GlyT1 with IC50 values of 5.2 nM in rat primary neurons and 5.0 nM in human SK-N-MC cells
- Single oral administration induces a dose-dependent increase of glycine cerebrospinal fluid (CSF) levels
- Related to neurological disease areas including membrane transporter/ion channel, neuronal signaling, and GlyT
Medchemexpress LLC Ombuoside | 20188-85-6 | 5 MG
Ombuoside is a compound with antioxidant properties, capable of inhibiting ROS production and apoptosis. It exhibits neuroprotective effects by acting through the ERK-JNK-caspase-3 system and promotes Dopamine biosynthesis via TH and CREB activation. Additionally, Ombuoside shows antimicrobial activity against various Gram-positive and Gram-negative bacteria, as well as Candida albicans.
- Antioxidant: Inhibits ROS production and apoptosis.
- Neuroprotective: Acts via the ERK-JNK-caspase-3 system.
- Dopamine biosynthesis: Promotes Dopamine biosynthesis through TH and CREB activation.
- Antimicrobial: Exhibits activity against several Gram-positive and Gram-negative bacteria, and Candida albicans.
- Purity: 99.68%.
- Appearance: White to light yellow solid.
- Research use only.
eMolecules 2184-85-2 | Ambeed | 2-(2-Chlorophenyl)propanoic acid | 250mg | 552668940 | A239275 | MFCD06658208 | 184.62 | C9H9ClO2
Medchem Express | Daucosterol | 5mg | 446275027 | HY-N0410 | 474-58-8 | MFCD01683621 | 576.859 | C35H60O6
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Medchemexpress LLC 3-(benzylthio)-5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazole | 129544-85-0 | 99.9% | C22H19N3OS | 10MG
MIND4-19 is a small-molecule SIRT2 inhibitor (IC50 7.0 μM) used as a research tool in studies of neurodegeneration, including Huntington's disease. The compound is a solid, white to off-white material with formula C22H19N3OS and a molecular weight of 373.47 g·mol⁻¹; it is supplied with high purity and storage recommendations to protect activity.
- Potent SIRT2 inhibition (IC50 7.0 μM).
- High chemical purity (>99.9%).
- Solid, white to off-white appearance for easy handling.
- Suitable for neurodegeneration and SIRT2 biology research.
- Storage conditions provided to preserve stability and activity.
![eMolecules 50269-86-8 | PYRROLO[1,2-D][1,2,4]TRIAZIN-1(2H)-ONE | AstaTech | MFCD09864428 | 135.126 | C6H5N3O | 95.000 | O=c1[nH]ncn2cccc12 | 0.25g | 273166549](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502460843.JPG-250.jpg)
eMolecules 50269-86-8 | PYRROLO[1,2-D][1,2,4]TRIAZIN-1(2H)-ONE | AstaTech | MFCD09864428 | 135.126 | C6H5N3O | 95.000 | O=c1[nH]ncn2cccc12 | 0.25g | 273166549
PYRROLO[1,2-D][1,2,4]TRIAZIN-1(2H)-ONE | AstaTech | 50269-86-8 | MFCD09864428 | 135.126 | C6H5N3O | 95.000 | O=c1[nH]ncn2cccc12 | 0.25g | 273166549
Medchemexpress LLC 5-hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one | 2133499-85-9 | MFCD32201069 | 99.7% | 264.30 | C13H12O4S | 5MG
HSP27 inhibitor J2 (J2) is a small-molecule inhibitor of heat shock protein 27 (HSP27) that induces abnormal HSP27 dimer formation and inhibits formation of HSP27 giant polymers, disrupting HSP27 chaperone function and reducing cellular protection. In cellular studies J2 enhances the antiproliferative activity of 17-AAG and sensitizes cells to cisplatin, supporting its use in mechanistic and combination oncology research.
- Inhibits HSP27 chaperone activity by promoting abnormal dimer formation.
- Enhances antiproliferative effects of HSP90 inhibition in cell assays.
- Sensitizes cells to platinum-based chemotherapy in vitro.
- High purity (99.7%) suitable for biochemical and cell-based studies.
- Supplied as milligram-scale solid packs with good DMSO solubility for assay preparation.
eMolecules 627034-85-9 | Medchem Express | NF449 (octasodium) | 1mg | 559839452 | HY-112461A | MFCD03791135 | 1505.05 | C41H24N6Na8O29S8
Medchem Express | NF449 (octasodium) | 1mg | 559839452 | HY-112461A | 627034-85-9 | MFCD03791135 | 1505.050 | C41H24N6Na8O29S8
eMolecules 376637-85-3 | (3-PHENOXYPHENYL)METHYLAMINE HCL | AstaTech | MFCD07781045 | 235.710 | C13H14ClNO | 95.000 | Cl.NCc1cccc(Oc2ccccc2)c1 | 1g | 112531058
(3-PHENOXYPHENYL)METHYLAMINE HCL | AstaTech | 376637-85-3 | MFCD07781045 | 235.710 | C13H14ClNO | 95.000 | Cl.NCc1cccc(Oc2ccccc2)c1 | 1g | 112531058
![Medchemexpress LLC 3H-pyrrolo[2,3-d]pyrimidine-4,6-dione derivative (pentafluoropropoxy, trifluoroethoxy phenyl) | 1236767-85-3 | 99.9% | 473.27 | C17H11F8N3O4 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000228000.png-250.jpg)
Medchemexpress LLC 3H-pyrrolo[2,3-d]pyrimidine-4,6-dione derivative (pentafluoropropoxy, trifluoroethoxy phenyl) | 1236767-85-3 | 99.9% | 473.27 | C17H11F8N3O4 | 50 MG
D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor provided as a high-purity research compound for in vitro and in vivo studies. The compound shows low-nanomolar potency and includes solubility and formulation guidance in the datasheet and COA.
- Selective delta-5 desaturase inhibitor with human IC50 22 nM and rat IC50 72 nM.
- High reported purity: 99.9% (LCMS).
- Molecular weight 473.27; formula C17H11F8N3O4.
- Supplied as 50 MG research quantity.
- DMSO solubility 125 mg/mL; in vivo formulation protocols provided.
- Quality supported by an accompanying COA and datasheet.
Medchemexpress LLC DB04760 (compound 4) | 544678-85-5 | MFCD09878513 | 99.2% | 410.42 g/mol | C22H20F2N4O2 | 10MG
DB04760 is a small-molecule MMP-13 inhibitor (compound 4) reported as a potent, highly selective, non-zinc-chelating inhibitor with an IC50 of 8 nM. It has been used in studies showing reduction of paclitaxel-induced neurotoxicity and anticancer activity, and is supplied for research use with defined purity and solubility characteristics.
- Potent MMP-13 inhibitor with IC50 = 8 nM.
- Highly selective non-zinc-chelating mechanism.
- Molecular formula C22H20F2N4O2, molecular weight 410.42 g/mol.
- CAS number 544678-85-5.
- Purity 99.2%.
- Soluble in DMSO at ≥100 mg/mL; in vivo formulation: 10% DMSO then 90% corn oil.
- Reported to reduce paclitaxel neurotoxicity and exhibit anticancer activity.
- Available in multiple small-scale pack sizes for research use.
Medchemexpress LLC GSK1702934A | 924377-85-5 | 99.11% | 395.52 | 50 MG
GSK1702934A is a selective TRPC3 agonist that modulates cardiac contractility and arrhythmogenesis by activation of TRPC3.
- Selective TRPC3 agonist.
- Modulates cardiac contractility and arrhythmogenesis.
- Induces TRPC3/6-currents in HEK293 cells.
- Induces a transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes.
- Promotes NCX currents in TRPC3-overexpressing myocytes.
- Transiently increases blood pressure in conscious Sprague Dawley rats.
- Useful for research applications.
- Available for research use only.
eMolecules 302799-86-6 | Medchem Express | TCS 46b | 5mg | 791205920 | HY-107707 | MFCD09971137 | 345.446 | C22H23N3O
Ambeed | 2-Chloro-4-methyl-56-dihydro-7H-cyclopenta[b]pyridin-7-one | 100mg | 490540447 | A234844 | 745075-82-5 | MFCD18255919 | 181.620 | C9H8ClNO
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![Medchemexpress LLC Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N' | 1166393-85-6 | 98.6% | 445.52 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387730-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N' | 1166393-85-6 | 98.6% | 445.52 | 50 MG
PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. It may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects, and for targeted bone regeneration.
- Potent and selective PYK2 inhibitor with an IC50 of 637 nM.
- Promotes osteogenesis of hMSC cultures, increasing alkaline phosphatase (ALP) activity and mineralization.
- Enhances osteoblast proliferation.
- Enhances calcium deposition.
- Increases cell proliferation activity in murine bone marrow-derived mesenchymal stem cells (BMSC).
eMolecules 19948-85-7 | Medchem Express | FAK-IN-7 | 5mg | 761041122 | HY-148109 | 295.36 | C16H13N3OS
Medchem Express | L-Valine-d8 | 5mg | 686240710 | HY-I1124 | 35045-72-8 | MFCD00144704 | 125.197 | C5H11NO2
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