Azolines

Organic heterocyclic compounds that consist of a five-membered ring made up of four carbon atoms and one nitrogen atom, and only one carbon - carbon double bond.

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136

Sigma Aldrich 1-Chloroisoquinoline

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

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CAS	19493-44-8

137

eMolecules 34301-54-7 | Adamantane-1-thiol | Ambeed168.300 | C10H16S | 95.000 | SC12CC3CC(CC(C3)C1)C2 | 5g | 553233158

Adamantane-1-thiol | Ambeed | 34301-54-7168.300 | C10H16S | 95.000 | SC12CC3CC(CC(C3)C1)C2 | 5g | 553233158

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138

Eagle Biosciences Inc Creatinine Serum Detection Kit, 2 x 96 well

Creatinine Serum Detection Kit

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139

Apexbio Technology LLC Serotonin HCl(Synonyms: Serotonin hydrochloride, 5-Hydroxytryptamine hydrochloride, 5-HT hydrochloride), 50mg, CAS: 153-98-0.

Serotonin hydrochloride (CAS 153-98-0) is a monoamine neurotransmitter naturally derived from tryptophan that functions as an endogenous agonist of serotonin (5-HT) receptors Additionally serotonin hydrochloride acts as a non-competitive inhibitor of the enzyme catechol O-methyltransferase (COMT) exhibiting a binding affinity (Ki) of approximately 44 M Serotonin modulates diverse physiological processes including mood regulation sleep appetite sexual function and gastrointestinal activity Due to its role in mediating neurological and inflammatory pathways serotonin hydrochloride is widely utilized in research studies investigating depression anxiety disorders migraine pathophysiology and inflammation-associated hypersensitivity

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140

Medchemexpress LLC Thiol-PEG6-alcohol | 194425-46-2 | ≥97.0% | 50 MG

Thiol-PEG6-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules containing two different ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein. They function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

PEG-based PROTAC linker
Used in the synthesis of PROTACs
Leverages the intracellular ubiquitin-proteasome system
Selectively degrades target proteins

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141

Medchemexpress LLC M-PEG-THIOL MW 2000 1G

M-PEG-THIOL MW 2000 1G

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142

Medchemexpress LLC NAG-thiazoline | 179030-22-9 | ≥95.0% | 219.26 | 25 MG

NAG-thiazoline is an O-GlcNAcase inhibitor with a Kᵢ of 180 nM. It is also a potent GH20 GlcNAcase (VhGlcNAcase) inhibitor with an IC₅₀ of 11.9 μM and a Kᵢ of 62 μM. It completely inhibits the growth of V. campbellii strain 650. This product is for research use only.

O-GlcNAcase inhibitor (Kᵢ of 180 nM)
Potent GH20 GlcNAcase (VhGlcNAcase) inhibitor (IC₅₀ of 11.9 μM, Kᵢ of 62 μM)
Inhibits the growth of V. campbellii strain 650 (MIC value of 0.5 μM)
Suitable for research applications

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143

eMolecules 1172472-37-5 | 2-IMIDAZOL-1-YL-1-ISOPROPYL-ETHYLAMINE 2HCL | AstaTech | MFCD04117727 | 226.150 | C8H17Cl2N3 | 95.000 | Cl.Cl.CC(C)C(N)Cn1ccnc1 | 1g | 112530796

2-IMIDAZOL-1-YL-1-ISOPROPYL-ETHYLAMINE 2HCL | AstaTech | 1172472-37-5 | MFCD04117727 | 226.150 | C8H17Cl2N3 | 95.000 | Cl.Cl.CC(C)C(N)Cn1ccnc1 | 1g | 112530796

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144

eMolecules 174500-20-0 | 2,6-Bis[(4s)-phenyl-2-oxazolin-2-yl]pyridine | Combi-Blocks | MFCD01863586 | 369.424 | C23H19N3O2 | 96.000 | C1OC(=N[C@H]1c1ccccc1)c1cccc(n1)C1=N[C@H](CO1)c1ccccc1 | 10g | 267164594

2,6-Bis[(4s)-phenyl-2-oxazolin-2-yl]pyridine | Combi-Blocks | 174500-20-0 | MFCD01863586 | 369.424 | C23H19N3O2 | 96.000 | C1OC(=N[C@H]1c1ccccc1)c1cccc(n1)C1=N[C@H](CO1)c1ccccc1 | 10g | 267164594