Benzodiazepines
Cayman Chemical Coelenterazine 400a hydrochl
A bisdeoxy derivative of coelenterazine that produces an emission maximum of 395 nm following conversion by Renilla luciferase; commonly used in BRET2 protocols to evaluate protein-protein interactions
Selleck Chemical LLC Coelenterazine
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase Renilla luciferase and substrate coelenterazine have been used as bioluminescence donors in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in the chemiluminescent detection of peroxynitrite
Medchemexpress LLC Clozapine N-oxide (dihydrochloride) | 2250025-93-3 | 99.7% | 415.74 | 100 MG
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and acts as an agonist for human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di. This compound cannot cross the blood-brain barrier. Clozapine, its parent compound, is a potent dopamine antagonist and a selective muscarinic M4 receptor agonist with an EC50 of 11 nM.
- Major metabolite of Clozapine
- Activates human muscarinic designer receptors (DREADDs) hM3Dq and hM4Di
- Cannot cross the blood-brain barrier
- Clozapine is a potent dopamine antagonist and selective muscarinic M4 receptor agonist
- Appearance: Solid
- Color: Light yellow to yellow
Medchemexpress LLC Clozapine N-oxide | 34233-69-7 | 99.9% | 342.82 | 1 ML
Clozapine N-oxide is a major metabolite of Clozapine and acts as an agonist for human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di but cannot cross the blood-brain barrier. Clozapine, its parent compound, is a potent dopamine antagonist and a selective muscarinic M4 receptor (EC50=11 nM) agonist.
- Purity: 99.87%
- Molecular weight: 342.82
- Formula: C18H19ClN4O
- Appearance: Solid, light yellow to yellow color
- Solubility in DMSO: 100 mg/mL (291.70 mM)
- Solubility in H2O: < 0.1 mg/mL (insoluble)
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 1 year, -20°C for 6 months
Medchemexpress LLC FAUC 365 50mg | 474432-66-1 | 462.44 g/mol | C23H25Cl2N3OS | 50 MG
FAUC 365 is a dopamine D3 receptor-selective antagonist supplied for preclinical research use. It exhibits high affinity for D3 with markedly lower affinity for D2 and D4 subtypes, and is used in studies of schizophrenia and Parkinson's disease models.
- High D3 receptor selectivity (reported Ki ≈ 0.5 nM)
- High purity (~98.8%)
- Available in solid packs and as a solution in DMSO
- Soluble in DMSO (~33.33 mg/mL); in vivo formulation guidance provided
- Recommended storage for powder and solutions to preserve stability
- Analytical documentation available (SDS, COA, H NMR, RP-HPLC, MS)
eMolecules Ambeed / 2345-Tetramethylaniline / 100mg / 601096959 / A213463 / / 2217-45-0 / MFCD19203597 / 149.237 / C10H15N
Ambeed / 2345-Tetramethylaniline / 100mg / 601096959 / A213463 / / 2217-45-0 / MFCD19203597 / 149.237 / C10H15N
Medchemexpress LLC Coelenteramine 400a | 70217-82-2 | MFCD04114093 | 99.7% | 391.5 g/mol | C26H21N3O | 25 MG
Coelenteramine 400a is a coelenterazine-derived luciferase substrate used for Renilla luciferase (RLuc) assays and bioluminescence resonance energy transfer (BRET) research. It produces blue bioluminescent emission with a peak near 395 nm and is supplied as a solid with high reported purity.
- Provides blue emission with peak near 395 nm.
- Suitable for Renilla luciferase (RLuc) assays and BRET research.
- High reported purity (99.7%).
- Supplied as a solid; store protected from light at -20°C.
- Available in small laboratory quantities (25 MG).
- Follow safety data sheet precautions; harmful if swallowed and may irritate skin, eyes, and respiratory system.
Medchemexpress LLC Clozapine N-oxide | 34233-69-7 | MFCD00210190 | >99.8% | 342.82 | 25 MG
Clozapine N-oxide is a major metabolite of Clozapine and acts as an agonist for human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di. Notably, Clozapine N-oxide does not cross the blood-brain barrier. Clozapine, its parent compound, is a potent dopamine antagonist and a potent and selective muscarinic M4 receptor agonist (EC50=11 nM).
- Activates the DREADD receptors hM3Dq and hM4Di.
- Does not cross the blood-brain barrier.
- Major metabolite of clozapine.
- Parent compound clozapine is a potent dopamine antagonist.
- Parent compound clozapine is a selective muscarinic M4 receptor agonist.
Medchemexpress LLC Clozapine N-oxide | 34233-69-7 | 99.9% | 342.82 | 50 MG
Clozapine N-oxide is a major metabolite of Clozapine and acts as an agonist for human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier. It undergoes reverse-metabolism to its parent compound clozapine, an atypical antipsychotic.
- Activates DREADD receptors hM3Dq and hM4Di
- Cannot cross the blood-brain barrier
- Undergoes reverse-metabolism to clozapine
- Suitable for laboratory centrifugation and storage
eMolecules Ambeed / 4-Propyl-2345-tetrafluoro-1141-terphenyl / 1g / 525032930 / A129324 / / 205806-88-8 / MFCD16038524 / 344.353 / C21H16F4
Ambeed / 4-Propyl-2345-tetrafluoro-1141-terphenyl / 1g / 525032930 / A129324 / / 205806-88-8 / MFCD16038524 / 344.353 / C21H16F4
eMolecules Ambeed / 2345-Tetramethylcyclopent-2-enone / 1g / 525089954 / A173061 / / 54458-61-6 / MFCD00010248 / 138.210 / C9H14O
Ambeed / 2345-Tetramethylcyclopent-2-enone / 1g / 525089954 / A173061 / / 54458-61-6 / MFCD00010248 / 138.210 / C9H14O
TARGETMOL CHEMICALS INC CLOZAPINE N-OXIDE 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4 whose activities in turn can be affected by drugs and disease [2]. Clozapine N-oxide is normally biologically inactive. However it can be used in designer receptor exclusively activated by designer drugs also known as DREADDs technology to modulate synthetic receptors in vivo [3]. purity: 99%
Sigma Aldrich Fine Chemicals Biosciences Clozapine | 5786-21-0 | MFCD00153785 | 25MG
Clozapine | Mol Wt: 326.82 | 5786-21-0 | MFCD00153785 | 25MG
