Benzodiazepines
TARGETMOL CHEMICALS INC Clozapine Analogues 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Clozapine Analogues can be used to study neurological disorders. Purity 99.6%
Medchemexpress LLC Coelenterazine | 55779-48-1 | 98.5% | 423.46 | 25 MG
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. It has been utilized as a bioluminescence donor in bioluminescence resonance energy transfer (BRET) for detecting protein-protein interactions. It also serves as a superoxide anion-sensitive chemiluminescent probe and can be employed in the chemiluminescent detection of peroxynitrite.
- Functions as a luminescent enzyme substrate
- Used as a bioluminescence donor in BRET for protein-protein interaction detection
- Acts as a superoxide anion-sensitive chemiluminescent probe
- Can be used for chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm)
Selleck Chemical LLC Coelenterazine
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase Renilla luciferase and substrate coelenterazine have been used as bioluminescence donors in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in the chemiluminescent detection of peroxynitrite
Medchemexpress LLC Coelenteramine 400a | 70217-82-2 | MFCD04114093 | 99.7% | 391.46 | C26H21N3O | 10 MG
Coelenteramine 400a is a coelenterazine-derived luciferase substrate used for Renilla luciferase assays, bioluminescence detection, and BRET studies. Supplied as a solid for research use, it is high-purity and should be protected from light during storage and handling.
- Produces 395-400 nm emission with Renilla luciferase
- High purity suitable for sensitive assays
- Solid form that dissolves in common organic solvents
- Recommended storage: -20°C, protect from light; in solvent: -80°C for long-term
- Offered in research-scale quantities for assay development
Alkali Scientific Coelenterazine H, 1 Mg
Coelenterazine H is a luminescent substrate widely used in biochemical assays, especially in studying the activity of luciferases. This 1mg reagent is used to trigger light emission in the presence of luciferase enzymes, making it valuable for applications in molecular biology, cell biology, and immunology. The light output provides a sensitive and quantifiable measure of enzymatic activity, making Coelenterazine H an essential tool for assay systems such as reporter gene assays and ATP measurements. Its ability to generate light makes it ideal for in vitro and in vivo imaging of biological processes, and it is commonly used in research related to cellular signaling, gene expression, and enzyme kinetics.
Enzo Life Sciences Clozapine, (50mg), CAS Number: 5786-21-0
Dopamine receptor and serotonin receptor antagonist. Dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors. Alternative Name: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]diazepine. Formula: C18H19ClN4. MW: 326.8. CAS Number: 5786-21-0. MI: 14: 2423. Purity: ≥99% (HPLC). Appearance: Yellow crystalline powder. Solubility: Soluble in DMSO (30mg/ml) or dilute aqueous acid. Long Term Storage: +4°C
Medchemexpress LLC Coelenterazine h (2-deoxycoelenterazine) | 50909-86-9 | 99.4% | 407.46 | C26H21N3O2 | 10 MG
Coelenterazine h (2-deoxycoelenterazine) is a yellow to orange solid luminescent substrate used in biochemical and cell-based assays. It functions as a substrate for Renilla luciferase, offers increased sensitivity to Ca2+ for detecting small calcium changes, and is supplied with high purity; the compound is unstable in solution and should be prepared fresh and stored protected from light at -20°C.
- Is a luminescent substrate for Renilla luciferase, enabling bioluminescent assays.
- Shows increased sensitivity to Ca2+, aiding detection of small calcium changes.
- Supplied as a yellow to orange solid with high purity (≈99.4%).
- Exhibits excitation/emission at 437/466 nm for assay matching.
- Is unstable in solution; prepare fresh solutions and store at -20°C protected from light.
Medchemexpress LLC Clozapine | 5786-21-0 | 99.8% | C18H19ClN4 | 100 MG
Clozapine is an antipsychotic used for the research of schizophrenia. It has high affinity for several neuroreceptors. Clozapine acts as a potent antagonist of dopamine D2 with a Ki of 75 nM. It also inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Ki values of 9.5 nM and 4 nM, respectively. Furthermore, Clozapine is a potent and selective agonist at the muscarinic M4 receptor (EC50 = 11 nM).
- Antagonist of dopamine D2 and α2-adrenoceptor
- Inhibits muscarinic M1 and serotonin 5HT2A receptors
- Potent and selective agonist at muscarinic M4 receptor
- Exhibits antipsychotic effects in mouse models
- Inhibits human dopamine receptor D4.2 and D2L receptor
Apexbio Technology LLC Coelenterazine 55779-48-1 5mg
Coelenterazine (CAS 55779-48-1) is a small molecule substrate for bioluminescent enzymes that generates a chemiluminescent signal upon oxidation by reactive oxygen species (ROS) particularly superoxide anions and peroxynitrite In rat hepatocytes it exhibits an IC50 of approximately 69 M toward superoxide anions Coelenterazine demonstrates concentration-dependent antioxidant activity enhancing cell viability and decreasing lipid peroxidation under oxidative stress induced by tert-butyl hydroperoxide It is widely applied in biomedical research including ELISA bioluminescence resonance energy transfer (BRET) high-throughput screening (HTS) and in vivo imaging studies of ROS in cancer models
Medchemexpress LLC Clozapine | 5786-21-0 | 99.8% | C18H19ClN4 | 50 MG
Clozapine (HF 1854) is an antipsychotic agent used for the research of schizophrenia. It has high affinity for several neuroreceptors. Clozapine acts as a potent antagonist of dopamine D2 (Ki of 75 nM), inhibits the muscarinic M1 receptor (Ki of 9.5 nM) and serotonin 5HT2A receptor (Ki of 4 nM), and is a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).
- Antipsychotic used in schizophrenia research
- High affinity for various neuroreceptors
- Potent antagonist of dopamine D2
- Inhibits muscarinic M1 receptor and serotonin 5HT2A receptor
- Potent and selective agonist at the muscarinic M4 receptor
- Available in solid and solution forms
Medchemexpress LLC Coelenterazine | 55779-48-1 | 98.45% | 423.46 | 100 MG
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. It has been used as a bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. It is also a superoxide anion-sensitive chemiluminescent probe that can be used in the chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm).
- Luminescent enzyme substrate for apoaequorin and Renilla luciferase.
- Used in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions.
- Superoxide anion-sensitive chemiluminescent probe.
- Can be used in chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm).
- For research use only.