Biotin and derivatives
Medchemexpress LLC Biotin-PEG10-NHS ester | 98.0% | C37H64N4O16S | 100 MG
Biotin-PEG10-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are compounds designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, featuring two ligands connected by a linker - one for an E3 ubiquitin ligase and another for the target protein.
- PEG-based linker
- Used in PROTAC synthesis
- Exploits ubiquitin-proteotein system
- Selectively degrades target proteins
- Features two ligands connected by a linker
Medchemexpress LLC Biotin-PEG4-acid | 721431-18-1 | 97.0% | 100 MG
Biotin-PEG4-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) are compounds with two ligands connected by a linker; one binds to an E3 ubiquitin ligase, and the other targets a specific protein, exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Can be utilized in the synthesis of protacs
- Has a purity of 97.0%
- Appears as a white to off-white solid
- Intended for research use only
Medchemexpress LLC PC biotin-PEG3-NHS ester | 2353409-93-3 | MFCD07110334 | 95.0% | 840.89 g/mol | C36H52N6O15S | 25 MG
PC Biotin-PEG3-NHS ester is a cleavable 3-unit polyethylene glycol (PEG) linker bearing a biotin tag and an N-hydroxysuccinimide (NHS) ester reactive group. It is used to attach biotin to primary amines and as an ADC linker in bioconjugation workflows.
- Cleavable 3-unit PEG spacer provides hydrophilicity and spacing.
- NHS ester enables efficient coupling to primary amines.
- Biotin tag enables affinity capture and detection.
- Molecular weight 840.89 g/mol, formula C36H52N6O15S, CAS 2353409-93-3.
- Typical purity 95.0%.
- Powder storage at -20 °C; in solution store at -80 °C for long-term stability.
- Available in small research pack sizes suitable for conjugation optimization.
=O)C(=O)Oc1ccc(cc1)[N+]([O-])=O | 1g | 526508582](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502179406.JPG-250.jpg)
eMolecules 104199-82-8 | BOC-D-ASN-ONP | AstaTech | MFCD00065559 | 353.331 | C15H19N3O7 | 97.000 | CC(C)(C)OC(=O)N[C@H](CC(N)=O)C(=O)Oc1ccc(cc1)[N+]([O-])=O | 1g | 526508582
BOC-D-ASN-ONP | AstaTech | 104199-82-8 | MFCD00065559 | 353.331 | C15H19N3O7 | 97.000 | CC(C)(C)OC(=O)N[C@H](CC(N)=O)C(=O)Oc1ccc(cc1)[N+]([O-])=O | 1g | 526508582
Medchemexpress LLC Biotin-PEG6-NHS ester | 2055045-04-8 | MFCD22056308 | 98.0% | C29H48N4O12S | 10MG
Biotin-PEG6-NHS ester is an amine-reactive, PEG-based linker containing a biotin tag and an N-hydroxysuccinimide (NHS) ester for labeling primary amines. It is commonly used to biotinylate proteins, peptides, and other amine-containing molecules and as a PEG-based linker in PROTAC synthesis to enable affinity capture or target engagement studies.
- Amine-reactive NHS ester for efficient, selective bioconjugation.
- PEG6 spacer provides a flexible, hydrophilic linker.
- Biotin tag enables streptavidin-based affinity capture and detection.
- High purity (98.0%) suitable for research applications.
- Solid form; store sealed at -20°C; in solvent store at -80°C (up to 6 months) or -20°C (up to 1 month).
- Compatible with protein and peptide labeling workflows.
Medchemexpress LLC Sulfo-NHS-Biotin sodium | 194041-65-1 | 95.0% | 443.43 Da | 100 MG
Sulfo-NHS-Biotin sodium is a low-molecular-weight tracer (443.4 Da) that is used to assess blood-brain barrier permeability. It functions as a passive tracer in animal models of traumatic brain injury, helping to measure blood-brain barrier leakage volume without exhibiting inherent pharmacodynamic effects.
- Low-molecular-weight (443.4 Da) tracer
- Assesses blood-brain barrier permeability
- Functions as a passive tracer
- No inherent pharmacodynamic effects
- Suitable for research use
Medchemexpress LLC TCO-NHS ester | 1191901-33-3 | 97.0% | C13H17NO5 | 25 MG
TCO-NHS ester is an alkyl/ether-based PROTAC linker designed for use in the synthesis of PROTACs. This compound functions as a click chemistry reagent, featuring a TCO group. This TCO group is capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) when combined with molecules that contain Tetrazine groups. PROTACs themselves are composed of two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. Their mechanism of action involves leveraging the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- Alkyl/ether-based PROTAC linker for PROTAC synthesis.
- Functions as a click chemistry reagent.
- Contains a TCO group that reacts with Tetrazine groups via iEDDA.
- Enables the creation of PROTACs which selectively degrade target proteins via the ubiquitin-proteasome system.
Medchemexpress LLC NHS-SS-biotin | 122266-55-1 | MFCD28505564 | 98.0% | 504.64 g/mol | C19H28N4O6S3 | 100 MG
NHS-SS-biotin is a cleavable disulfide-containing biotin linker with an N-hydroxysuccinimide (NHS) ester reactive group. It is used to introduce a biotin tag onto primary amines and as a reducible linker in antibody-drug conjugate synthesis and other bioconjugation workflows.
- Cleavable disulfide linker for reductive release.
- NHS ester reactive toward primary amines.
- Useful for protein and peptide biotinylation and affinity capture.
- Available in small-scale quantities suitable for research applications.
- Purity typically 98.0% as provided in supplier documentation.
Medchemexpress LLC Biotin-PEG3-NHS ester | 1253286-56-4 | 98.4% | 50 MG
Biotin-PEG3-NHS ester is a PEG-based PROTAC linker, specifically designed for use in the synthesis of PROTACs. Proteolysis Targeting Chimeras (PROTACs) function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This compound exhibits a high purity of 98.35%, has a molecular weight of 544.62, and the chemical formula C23H36N4O9S. It is presented as a solid, ranging in color from white to light yellow.
- Functions as a PEG-based linker for the synthesis of PROTACs.
- Enables PROTACs to exploit the intracellular ubiquitin-proteasome system for targeted protein degradation.
- Offers a high purity of 98.35%.
- Molecular weight: 544.62; formula: C23H36N4O9S; CAS No.: 1253286-56-4.
- Available as a solid, with a color ranging from white to light yellow.
Medchemexpress LLC UV Cleavable Biotin-PEG2-Azide | 1192802-98-4 | MFCD28505541 | 95.58% | C38H51N7O9S | 50 MG
UV Cleavable Biotin-PEG2-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Azide group for Cu(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
Medchemexpress LLC Biotin (Standard) | 58-85-5 | 99.8% | 250 MG
Biotin (Standard) is the analytical standard of Biotin. Biotin, also known as vitamin B7, serves as a coenzyme for five carboxylases in humans and is involved in the synthesis of fatty acids, isoleucine, and valine, as well as in gluconeogenesis. It is essential for cell growth, fatty acid production, and the metabolism of fats and amino acids.
- Analytical standard of Biotin
- Serves as a coenzyme for five carboxylases in humans
- Involved in the synthesis of fatty acids, isoleucine, and valine
- Involved in gluconeogenesis
- Essential for cell growth, fatty acid production, and metabolism of fats and amino acids
- Used as a reference standard in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
Medchemexpress LLC Biotin | 58-85-5 | 99.8% | 10 G
Biotin, also known as vitamin B7 or vitamin H, serves as a coenzyme for five carboxylases in humans. It is involved in the synthesis of fatty acids, isoleucine, and valine, as well as in gluconeogenesis. Biotin is essential for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
- Serves as a coenzyme for five carboxylases in humans
- Involved in the synthesis of fatty acids, isoleucine, and valine
- Involved in gluconeogenesis
- Essential for cell growth
- Essential for the production of fatty acids
- Essential for the metabolism of fats and amino acids
Medchemexpress LLC N3-PEG3-C2-NHS ester | 1245718-89-1 | 99.9% | 344.32 g/mol | C13H20N4O7 | 1 G
N3-PEG3-C2-NHS ester is an azide-terminated PEG3 linker bearing an N-hydroxysuccinimide (NHS) ester reactive group, designed for coupling to primary amines and for use in click-chemistry workflows such as antibody-drug conjugate (ADC) synthesis.
- Azide-terminated PEG3 linker for click chemistry applications.
- NHS ester reactive handle for coupling to primary amines.
- Non-cleavable linker suitable for stable bioconjugation.
- Reported high chemical purity for research use.
- Available in multiple pack sizes including 1 G for laboratory-scale synthesis.
Medchemexpress LLC L-biotin | 21788-37-4 | 99.7% | 244.31 | C10H16N2O3S | 25 MG
L-biotin is the unnatural enantiomer of biotin and is used as a biochemical research reagent. It is provided as a white to off-white solid with reported high purity and has been observed to bind streptavidin in laboratory assays.
- High purity suitable for research applications.
- White to off-white solid, easy to handle and store.
- Soluble in DMSO at high concentration for in vitro use.
- Available in small solid quantities appropriate for bench-scale experiments.
- Stable when stored frozen as a powder to extend shelf life.
Medchemexpress LLC m-PEG15-NHS ester | 98.0% | 100 MG
m-PEG15-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. These Proteolysis Targeting Chimeras consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for a target protein. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This compound has a molecular weight of 875.99 and a chemical formula of C39H73NO20. It appears as a white to off-white solid below 35°C and a liquid above 35°C.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Molecular weight: 875.99
- Chemical formula: C39H73NO20
- Appears as a white to off-white solid below 35°C
- Liquid above 35°C
- Store at -20°C in sealed storage, away from moisture and light
- In solvent, stable for 6 months at -80°C or 1 month at -20°C