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Dithioles

Organosulfur heterocyclic compounds that consist of a five-membered ring with two sulfur atoms, three carbon atoms, and a carbon - carbon double bond.

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1

Medchemexpress LLC Thiolutin (Acetopyrrothin) | 87-11-6 | 10 MG
SDP

Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic and a potent inhibitor of bacterial and yeast RNA polymerases. Produced by Streptomyces, it functions as a dual inhibitor of BRCC36 and the NLRP3 inflammasome, demonstrating anti-inflammatory and anti-angiogenic properties.

  • Sulfur-containing antibiotic
  • Potent inhibitor of bacterial and yeast RNA polymerases
  • Inhibits AMSH and Rpn11
  • Dual inhibitor of BRCC36 and the NLRP3 inflammasome
  • Anti-inflammatory effects
  • Inhibits HCC growth by suppressing BRCC36 and HMGCR interaction
  • Attenuates pyroptosis and NLRP3 inflammasome activation
  • Alleviates renal injury and inflammatory processes in IgAN
  • Acts as an anti-angiogenic compound
  • Eases Doxorubicin-induced cardiotoxicity

ENCOMPASS_PREFERRED
2

Medchemexpress LLC Thiolutin | 87-11-6 | 25 MG
SDP

Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic and a potent inhibitor of bacterial and yeast RNA polymerases. It acts as a dual inhibitor of BRCC36 and the NLRP3 inflammasome, demonstrating anti-inflammatory effects. It suppresses the interaction between BRCC36 and HMGCR, inhibiting HCC growth, attenuating pyroptosis and NLRP3 inflammasome activation, and alleviating renal injury and inflammatory processes. Thiolutin is also an anti-angiogenic compound that can ease Doxorubicin-induced cardiotoxicity (DOXIC).

  • Potent inhibitor of bacterial and yeast RNA polymerases.
  • Dual inhibitor of BRCC36 and the NLRP3 inflammasome.
  • Exhibits anti-inflammatory properties and attenuates pyroptosis.
  • Suppresses BRCC36 and HMGCR interaction, inhibiting HCC growth.
  • Alleviates renal injury in IgAN and Doxorubicin-induced cardiotoxicity.
  • Can be produced by Streptomyces.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Thiolutin (acetopyrrothin) | 87-11-6 | 1 ML
SDP

Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic and a potent inhibitor of bacterial and yeast RNA polymerases. It is produced by Streptomyces. Thiolutin inhibits AMSH (IC50 = 4 μM) and Rpn11 (IC50 = 0.53 μM). It acts as a dual inhibitor of BRCC36 and the NLRP3 inflammasome, demonstrating anti-inflammatory effects and effectively suppressing the interaction between BRCC36 and HMGCR, thereby inhibiting HCC growth.

  • Potent inhibitor of bacterial and yeast RNA polymerases.
  • Inhibits AMSH (IC50 = 4 μM) and Rpn11 (IC50 = 0.53 μM).
  • Dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects.
  • Suppresses the interaction between BRCC36 and HMGCR, inhibiting HCC growth.
  • Attenuates pyroptosis and NLRP3 inflammasome activation.
  • Alleviates renal injury and inflammatory process in IgAN.
  • Anti-angiogenic compound that can ease doxorubicin-induced cardiotoxicity (DOXIC).

ENCOMPASS_PREFERRED