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Etiocholanolone (5β-Androsterone) is an excreted metabolite of testosterone with anticonvulsant activity. It is also described as a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor compared to its enantiomer form.
Excreted metabolite of testosterone
Anticonvulsant activity
Neurosteroid positive allosteric modulator (PAM) of the GABAA receptor
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Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form.
It is the excreted metabolite of testosterone.
It has anticonvulsant activity.
It is a less potent neurosteroid positive allosteric modulator of the GABAA receptor than its enantiomer form.
It exhibits ED50 values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively.
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Etiocholanolone (5β-androsterone) is an endogenous metabolite of testosterone provided as a high-purity research standard. It demonstrates anticonvulsant activity and functions as a neurosteroid positive allosteric modulator (PAM) of GABAA receptors, making it useful for biochemical, pharmacological, and analytical applications.
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