Indoles and derivatives

Medchemexpress LLC 2-amino-3-(3-[(10,12-dicyano-11-(4-(methylcarbamoyl)methoxy)phenyl)carbamoyl]phenyl)propanoic acid | 1941174-13-5 | 99.8% | 1 ML

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KMH-233 is a potent, reversible, and selective inhibitor of the L-type amino acid transporter LAT1 (SLC7A5), used in biochemical and cellular research to inhibit leucine uptake and suppress cell growth.

• Inhibits LAT1-mediated leucine uptake (IC50 = 18 μM).
• Potentiates the efficacy of bestatin and cisplatin at low concentrations.
• Supplied as a 10 mM solution in DMSO, 1 mL.
• Molecular formula C32H25N7O5 and molecular weight 587.58.
• High purity (99.8%) suitable for research use.

eMolecules​ Ambeed / (S)-()-22-Bis[di(35-di-i-propyl-4-dimethylaminophenyl)phosphino]-66-dimethoxy-11-biphenyl / 100mg / 600841492 / A485957 / / 919338-66-2 / MFCD09753010 / 1091.544 / C70H100N4O2P2

Ambeed / (S)-()-22-Bis[di(35-di-i-propyl-4-dimethylaminophenyl)phosphino]-66-dimethoxy-11-biphenyl / 100mg / 600841492 / A485957 / / 919338-66-2 / MFCD09753010 / 1091.544 / C70H100N4O2P2

Medchemexpress LLC Snt-207858 (free base) | 1104662-66-9 | 99.7% | 616.62 | 1 ML

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SNT-207858 free base is a selective, blood-brain barrier penetrating, potent, and orally active melanocortin-4 (MC-4) receptor antagonist. It demonstrates high affinity and selectivity for the MC-4 receptor, with an IC50 of 22 nM (binding) and 11 nM (function), showing 170-fold selectivity over MC-3 and 40-fold over MC-5. In preclinical studies, SNT-207858 significantly reduced tumor-induced weight loss in mice.

• Selective melanocortin-4 (MC-4) receptor antagonist
• Blood-brain barrier penetrating
• Orally active
• High potency with IC50 of 22 nM (binding) and 11 nM (function) on MC-4 receptor
• Shows 170-fold selectivity versus MC-3 and 40-fold selectivity versus MC-5
• Significantly reduces tumor-induced weight loss in mice with C26 adenocarcinoma-induced cachexia

Medchemexpress LLC SNT-207858 free base | 1104662-66-9 | 99.7% | 616.62 | 1 ML

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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SNT-207858 free base is a selective, blood-brain barrier penetrating, potent, and orally active melanocortin-4 (MC-4) receptor antagonist. It exhibits high affinity and selectivity for the MC-4 receptor, making it suitable for various research applications.

• Selective MC-4 receptor antagonist.
• Blood-brain barrier penetrating.
• Potent and orally active.
• IC50 for MC-4 receptor (binding): 22 nM.
• IC50 for MC-4 receptor (function): 11 nM.
• 170-fold selectivity versus MC-3.
• 40-fold selectivity versus MC-5.
• Reduces tumor-induced weight loss in C26 adenocarcinoma-induced cachexia models.