Lactams
Medchemexpress LLC Thalidomide-PEG4-COOH | 2828438-28-2 | 95.4% | 478.45 | 25 MG
Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Utilized in PROTAC technology
- Targets cereblon
- Associated with cancer, cancer targeted therapy, cancer metabolism, and metastasis research
- Relevant to autophagy and apoptosis studies
- Functions as an inhibitor
Medchemexpress LLC Thalidomide-1-me-5-nh2 | 1468761-60-5 | >98.0% | 287.27 g·mol-1 | C14H13N3O4 | 50 MG
Thalidomide-1-Me-5-NH2 is an aminated thalidomide analogue used as a cereblon E3 ligase ligand and building block for PROTAC design and related chemical biology research. It is intended for derivatization at the amine for linker attachment and is supplied as a high-purity research reagent suitable for synthetic applications.
- Aminated thalidomide analogue enabling linker derivatization
- Serves as a cereblon E3 ligase ligand for PROTAC design
- High purity for research applications (>98.0%)
- Supplied in small milligram-scale quantities suitable for synthesis (50 mg)
- Molecular formula C14H13N3O4, molecular weight 287.27 g·mol-1
- CAS number 1468761-60-5 for unambiguous identification
Medchemexpress LLC Thalidomide-Piperazine-PEG2-NH2 (diTFA) | 99.7% | 701.57 | 25 MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Includes a linker used in PROTAC technology
- Targets Cereblon
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-CH2NH2 hydrochloride | 444287-40-5 | 98.1% | 323.73 | 100 MG
Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, a versatile functional group that can participate in various reactions. It is intended for research use only.
- Features a primary amine group
- Provided as a solid, white to off-white in color
- Ships at room temperature in continental US
- Powder storage at -20°C for 3 years, 4°C for 2 years
- Storage in solvent at -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.9% | 276.22 | 5 G
Thalidomide 4-fluoride is a Thalidomide-based Cereblon ligand that recruits CRBN protein and can be linked to the ligand for IRAK4 protein to create PROTAC IRAK4 degrader-1. This compound targets cereblon (CRBN), a ubiquitous protein involved in the cullin-4 E3 ubiquitin ligase complex CRL4, facilitating the ubiquitination and subsequent proteasomal degradation of target proteins.
- Recruits CRBN protein.
- Can be linked to IRAK4 protein ligand.
- Targets cereblon (CRBN).
- Facilitates ubiquitination and proteasomal degradation of target proteins.
- Molecular weight: 276.22.
- Physical state: solid.
- Color: off-white to gray.
- Soluble in DMSO.
- Store powder at -20°C for 3 years or 4°C for 2 years.
- Store in solvent at -80°C for 2 years or -20°C for 1 year.
- Avoid repeated freeze-thaw cycles after preparation into solution.
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2H-isoindol-2-yl)- | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g/mol | C13H11IN2O3 | 500 MG
Deoxy-thalidomide-5-iodine is a thalidomide analog used as a cereblon-binding ligand scaffold in PROTAC and chemical biology research. Provided as a research-grade small molecule with reported purity suitable for biochemical and cell-based studies.
- Purity reported as 98.0%.
- Suitable for PROTAC ligand development and E3 ligase recruitment studies.
- Iodinated scaffold enables further functionalization or conjugation chemistry.
- Available in multiple pack sizes, including 500 mg, for scale flexibility.
- Molecular formula C13H11IN2O3; molecular weight 370.14 g/mol.
Medchemexpress LLC Thalidomide-O-amido-PEG4-propargyl | 2496687-00-2 | 98.0% | C26H31N3O10 | 50 MG
Thalidomide-O-amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide 10 mM * 1 mL in DMSO Solution
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.
Medchemexpress LLC Thalidomide-NH-CBP/p300 ligand 2 (P-007) | 2484739-21-9 | 98.6% | 922.03 | 100 MG
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader, extracted from patent WO2020173440. This product is for research use only.
- PROTAC-based CBP and p300 degrader
- Extracted from patent WO2020173440
- For research use only
- Targets cereblon
Medchemexpress LLC Thalidomide-NH-PEG3-NH-Boc | 2204246-03-5 | 548.59 | 50 MG
Thalidomide-NH-PEG3-NH-Boc is a laboratory chemical intended for research use only. It is suitable for the manufacture of substances and should be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- For laboratory use
- For research purposes only
- To be handled by experienced personnel
- Requires appropriately equipped and authorized facilities
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | 100 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research purposes only.
- Incorporates a thalidomide-based cereblon ligand
- Designed for use in PROTAC technology
- Targets cereblon
- Appears as a white to yellow solid
- Useful in cancer research applications
- Functions as an E3 ligase ligand-linker conjugate
- Involved in autophagy and apoptosis studies
- Acts as an inhibitor
Medchemexpress LLC Thalidomide-4-o-c5-nh2 | 2307477-23-0 | 359.38 | 100 MG
Thalidomide-4-O-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide-based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not for sale to patients.
- Target: Cereblon
- Formula: C18H21N3O5
- For research use only
- Not for sale to patients
Medchemexpress LLC Thalidomide-o-amido-PEG4-azide | 2411681-89-3 | 99.2% | C25H32N6O10 | 25 MG
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. This compound also functions as a versatile click chemistry reagent due to its azide group, enabling both copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with appropriate alkyne-containing molecules. PROTACs, which utilize this linker, are designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used for synthesizing PROTACs
- Functions as a click chemistry reagent
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Exploits the ubiquitin-proteasome system
- Supports selective degradation of target proteins