Lactams
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00078028 | 99.98% | 258.23 | 500 MG
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of approximately 250 nM. It possesses immunomodulatory, anti-inflammatory, and anti-angiogenic cancer properties. Thalidomide can also function as a molecular glue to potentiate substrate.
- Inhibits cereblon (CRBN), a component of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.
- Demonstrates immunomodulatory, anti-inflammatory, and anti-angiogenic properties.
- Functions as a molecular glue to potentiate substrate.
- Potentiates the anti-tumor activity of Icotinib against PC9 and A549 cell proliferation.
- Inhibits EGFR and VEGF-R2 pathways in PC9 cells.
- Alleviates RILF by suppressing ROS and down-regulating the TGF-β/Smad pathway.
Sigma Aldrich Fine Chemicals Biosciences Strychnine | 57-24-9 | MFCD00005941 | 5G
Strychnine | Mol Wt: 334.41 | 57-24-9 | MFCD00005941 | 5G
Sigma Aldrich Fine Chemicals Biosciences Aztreonam US Ph200mg
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
eMolecules 68373-14-8 | Medchem Express | Sulbactam | 100mg | 446272524 | HY-B0334 | 233.24 | C8H11NO5S
Medchem Express | Sulbactam | 100mg | 446272524 | HY-B0334 | 68373-14-8 | 233.240 | C8H11NO5S
TARGETMOL CHEMICALS INC Tazobactam 1G
Also available in 1 mL, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Tazobactam (YTR-830H) is an antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases. Purity 100%
Medchemexpress LLC Tazobactam sodium | 89785-84-2 | 99.7% | 322.27 | 100 MG
Tazobactam sodium is an antibiotic belonging to the beta-lactamase inhibitor class. It is combined with Ceftolozane to enhance the activity of ceftolozane against various ESBL-producing Enterobacteriaceae and some *Bacteroides spp.*. It is intended for research use only and not for sale to patients. In vitro studies show that Tazobactam sodium (0.045 mg/mL Piperacillin/Tazobactam, 3 days) can induce oxidative stress and mitochondrial damage, leading to apoptosis in HK-2 cells when used with Piperacillin. In vivo, Tazobactam sodium (300-500 mg/kg of Piperacillin/Tazobactam, iv, single dose) has been observed to cause direct nephrotoxicity, including tubular damage and mitochondrial structure alteration, in C57BL/6 mouse models.
- Beta-lactamase inhibitor
- Extends activity of ceftolozane against ESBL-producing Enterobacteriaceae and *Bacteroides spp*.
Apexbio Technology LLC Sulbactam sodium 69388-84-7 10mM (in 1mL H2O)
Sulbactam sodium is a competitive and irreversible inhibitor targeting -lactamase enzymes It functions predominantly through binding the active site of -lactamases thereby obstructing these enzymes from hydrolyzing -lactam antibiotics Widely employed in biomedical research Sulbactam sodium is utilized for evaluating bacterial resistance mechanisms characterizing susceptibility profiles of -lactamase-expressing clinical isolates and examining synergistic therapeutic combinations Moreover Sulbactam sodium itself exhibits antimicrobial activity notably against Acinetobacter species clinically resistant to common antibiotics In antibacterial assays against certain -lactamase-producing bacterial strains Sulbactam sodium typically demonstrates inhibitory effects at IC50 values ranging approximately from 5 to 25 g/mL depending upon specific experimental conditions
![Medchemexpress LLC N-[2-amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide | 1609389-52-7 | 99.6% | 429.54 g/mol | C24H23N5OS | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243882.png-250.jpg)
Medchemexpress LLC N-[2-amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide | 1609389-52-7 | 99.6% | 429.54 g/mol | C24H23N5OS | 100 MG
ACY-957 is a small-molecule, orally active inhibitor selective for histone deacetylases HDAC1 and HDAC2, used in preclinical research to modulate epigenetic regulation and induce γ-globin expression. CAS 1609389-52-7; formula C24H23N5OS; molecular weight 429.54 g/mol.
- Selective inhibition of HDAC1 and HDAC2 (IC50 7 nM and 18 nM)
- Markedly reduced activity against HDAC3 (IC50 ≈ 1,300 nM), supporting class I selectivity
- Orally active in preclinical models, suitable for in vivo dosing studies
- High reported purity for research-grade material (~99.6%)
- Solid, light yellow to yellow form; stable when stored at -20 °C
- Used to study epigenetic regulation and hemoglobin induction in preclinical research