Lactams
Medchemexpress LLC Tazobactam | 89786-04-9 | 5 G
Tazobactam (CL-298741) is a potent β-lactamases inhibitor and a penicillin antibiotic. It exhibits antibacterial activity and can be used for pneumonia research. This product is intended for research and analytical applications.
- Potent β-lactamases inhibitor
- Penicillin antibiotic
- Exhibits antibacterial activity
- Can be used for pneumonia research
- Intended for research and analytical applications
Medchemexpress LLC Thalidomide-O-PEG4-amine hydrochloride | 2820929-03-9 | C23H32ClN3O9 | 250MG
Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound is designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Designed for selective degradation of target proteins
Medchemexpress LLC Thalidomide-CH2NH2 hydrochloride | 444287-40-5 | MFCD32183715 | 98.0% | 323.73 g/mol | C14H14ClN3O4 | 10 MG
Thalidomide-CH2NH2 hydrochloride is a thalidomide analogue supplied as the hydrochloride salt for research use. It features a primary aminomethyl substituent that enables further functionalization and utility as a ligand-like scaffold in biochemical studies. The compound is provided as a high-purity solid suitable for synthetic chemistry and assay development.
- Contains a primary aminomethyl group for synthetic functionalization.
- Supplied as the hydrochloride salt for improved stability and handling.
- High purity suitable for research and assay development.
- Serves as a ligand scaffold for E3 ligase-related studies.
- Available in small-scale quantities for discovery workflows.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 | C13H9FN2O4 | 1 ML
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used as a building block in targeted protein degradation (PROTAC) research and related chemical biology applications. It is supplied as both solid material and pre-formulated DMSO solutions to facilitate linker conjugation and assay use.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- Cas number: 835616-61-0.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- Purity reported at 99.96% (analytical).
- Available as 10 mM solution in DMSO (1 mL) and as solid in multiple package sizes.
- Storage: powder at -20°C or 4°C; in solvent at -80°C or -20°C.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | MFCD30188075 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 1 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used as an E3 ligase recruiting moiety in chemical biology and PROTAC research. It is supplied as a powder and as a 10 mM DMSO solution for laboratory use.
- High purity: 99.96%
- Molecular weight: 276.22 g/mol
- Chemical formula: C13H9FN2O4
- Available sizes: 1 mL (10 mM in DMSO), 1 G, 5 G, 10 G, 25 G, 50 G
- Recommended storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 6 months) or -20°C (up to 1 month)
- Safety and quality documents: SDS and COA provided by manufacturer
Medchemexpress LLC Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]- | 2412056-27-8 | 95.0% | C15H13N3O6 | 25 MG
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk) and functions as a ligand of E3 ligase. This PROTAC leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins, holding potential for researching various diseases, as extracted from patent WO2021170109A1. This product is for research use only.
- Potent and selective inhibitor of tropomyosin receptor kinase (trk)
- Functions as a ligand for E3 ligase
- PROTAC (proteolysis-targeting chimera) technology
- Utilizes the ubiquitin-proteasome system to degrade target proteins
- Potential for researching various diseases
Medchemexpress LLC Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride | 2341841-02-7 | MFCD32705133 | 99.3% | 410.81 | 50 MG
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride is a chemical compound designed for the development of PROTACs (Proteolysis Targeting Chimeras). It functions by incorporating a cereblon (CRBN) ligand, which is essential for E3 ubiquitin ligase binding, alongside a linker. This product is strictly for research purposes and is not intended for patient use or clinical applications.
- Incorporates a cereblon (CRBN) ligand for E3 ubiquitin ligase binding
- Features a versatile linker for PROTAC design
- A key component for PROTAC research and development
- Facilitates targeted protein degradation studies
- Suitable for chemical biology and drug discovery research
Medchemexpress LLC Thalidomide-O-PEG4-Boc | 2411681-87-1 | C28H38N2O11 | 50 MG
Thalidomide-O-PEG4-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 25 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used in targeted protein degradation research and PROTAC synthesis. It is supplied as a high-purity solid and as a DMSO solution, with analytical data and safety documentation available.
- Thalidomide-based cereblon ligand for PROTAC development and E3 ligase recruitment studies.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- High purity (99.96%).
- Available as solid in 1 g, 5 g, 10 g, 25 g quantities.
- Solution option available as 10 mM in DMSO.
- Supplied with supporting documentation including COA, SDS, HNMR, RP-HPLC, and MS.
Medchemexpress LLC Thalidomide-O-amido-PEG4-azide | 2411681-89-3 | 99.19% | C25H32N6O10 | 100 MG
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs utilizing this linker are engineered to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent with Azide group
- Enables CuAAc reactions with alkyne groups
- Facilitates SPAAC reactions with DBCO or BCN groups
- Used in the synthesis of PROTACs
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | 586.03 | 100 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. For research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Utilizes a linker in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 5-[2-(2-chloroethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- | 2230956-57-5 | 96.6% | 380.78 | 25 MG
Thalidomide-5-PEG2-Cl is a thalidomide-based cereblon ligand that facilitates the recruitment of CRBN protein. It can be linked to a target protein ligand to create PROTACs, which are designed to harness the intracellular ubiquitin-proteasome system for selective protein degradation.
- Functions as a thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a protein ligand via a linker to form PROTACs
- PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-5-O-C8-NH2 hydrochloride | ≥98% | 437.92 | 5 MG
Thalidomide-5-O-C8-NH2 hydrochloride is a cereblon ligand derived from Thalidomide. It is utilized to recruit CRBN protein and can be linked to a target protein ligand via a linker to form PROTACs.
- It is a cereblon ligand.
- It is used in the recruitment of CRBN protein.
- It can be connected to a ligand for protein by a linker to form PROTACs.
- It is intended for research purposes only and not for sale to patients.
Medchemexpress LLC Thalidomide-Piperazine-PEG3-COOH | 2797619-63-5 | 99.89% | 546.57 | 25 MG
A synthesized ligand-linker conjugate is described as incorporating a cereblon ligand and a linker often employed in protein degradation technology. This conjugate is intended for research applications only and not for patient use.
- Synthesized conjugate.
- Incorporates a cereblon ligand.
- Utilizes a linker as part of protein degradation technology.
- Composed of two distinct ligands joined by a linker.
- One ligand targets an E3 ubiquitin ligase.
- The other ligand targets a specific protein.
- Leverages the intracellular ubiquitin-proteasome system.
- Aims for selective degradation of target proteins.
- For research purposes only.