Lactams
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.9 % | 276.22 | 50 G
Thalidomide 4-fluoride is a Thalidomide-based Cereblon ligand designed for the recruitment of CRBN protein. It can be linked to other ligands by a linker to form PROTAC degraders. In vitro, Thalidomide targets cereblon (CRBN), a ubiquitously expressed protein that is part of the cullin-4 E3 ubiquitin ligase complex. Cereblon mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to other ligands to form PROTAC degraders
- Targets cereblon (CRBN), a protein involved in the cullin-4 E3 ubiquitin ligase complex
- Mediates ubiquitination and proteasomal degradation of target proteins
- High purity for reliable research
- Solid appearance, off-white to gray color
- Stable under recommended storage conditions
- Soluble in DMSO (200 mg/mL)
Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | 95.0% | 332.26 g/mol | C15H12N2O7 | 25 MG
Thalidomide-5-O-CH2-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate used as a cereblon ligand in chemical biology and targeted protein degradation research. It is supplied as a solid reagent intended for in vitro studies and synthetic applications.
- Acts as a cereblon (CRBN) ligand for targeted protein degradation studies.
- Designed as a ligand-linker conjugate to enable attachment to target-binding warheads.
- High solubility in DMSO (125 mg/mL) facilitates preparation of concentrated stocks.
- Supplied with typical purity of 95.0% suitable for research use.
- Molecular weight 332.26 g/mol and formula C15H12N2O7 for accurate dosing.
- Stable as a powder when stored frozen for long-term retention.
- Accompanied by datasheet, certificate of analysis, and safety data for handling guidance.
Medchemexpress LLC Thalidomide-5-O-C14-NH2 hydrochloride | 97.7% | 522.08 | 25 MG
Thalidomide-5-O-C14-NH2 hydrochloride is a thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It can be connected to a ligand for protein by a linker to form PROTACs.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a ligand for protein by a linker
- Forms PROTACs
- Targets cereblon
Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 | 100 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate, incorporating the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This click chemistry reagent contains an Azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules or strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It is designed for research applications related to PROTACs, which utilize the ubiquitin-proteasome system to degrade target proteins.
- Incorporates cereblon ligand and a linker for PROTAC technology
- Click chemistry reagent with an Azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Designed for research in protein degradation via PROTACs
Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 | 50 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product is also a click chemistry reagent, containing an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a thalidomide-based cereblon ligand
- Features a linker used in PROTAC technology
- Functions as a click chemistry reagent with an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Allows strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Supports selective degradation of target proteins through PROTACs
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 4-[(6-azidohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- | 2411389-65-4 | 99.10% | 399.40 | 25 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It functions as a click chemistry reagent, containing an Azide group, which allows it to undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules that have Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a cereblon ligand
- Functions as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Exploits intracellular ubiquitin-proteasome system for selective target protein degradation
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00078028 | 99.98% | 258.23 | 500 MG
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of approximately 250 nM. It possesses immunomodulatory, anti-inflammatory, and anti-angiogenic cancer properties. Thalidomide can also function as a molecular glue to potentiate substrate.
- Inhibits cereblon (CRBN), a component of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.
- Demonstrates immunomodulatory, anti-inflammatory, and anti-angiogenic properties.
- Functions as a molecular glue to potentiate substrate.
- Potentiates the anti-tumor activity of Icotinib against PC9 and A549 cell proliferation.
- Inhibits EGFR and VEGF-R2 pathways in PC9 cells.
- Alleviates RILF by suppressing ROS and down-regulating the TGF-β/Smad pathway.
![Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.3% | 440.95 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387076-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.3% | 440.95 | 5 MG
DDL-357 is a potent enhancer of secreted clusterin. It has been shown to reduce phospho-tau levels in the brain and improve memory in the murine 3xTg-AD model. It is intended for research use only and not for sale to patients.
- Purity: 98.31%
- Appearance: Solid
- Color: White to off-white
- Shipping: Room temperature in continental US; may vary elsewhere.
- Storage (powder): -20°C for 3 years, 4°C for 2 years.
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month.
- Solubility (in vitro): 100 mg/mL in DMSO (226.78 mM; requires ultrasonic, hygroscopic DMSO affects solubility).
- Solubility (in vivo - protocol 1): ≥ 5 mg/mL (11.34 mM) in a mixture of 10% DMSO, 40% PEG300, 5% Tween-80, and 45% Saline, yielding a clear solution.
Medchemexpress LLC Thalidomide-NH-PEG4-COOH | 2412056-48-3 | 96.7% | 521.52 | 50 MG
Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.
- E3 ligase ligand-linker conjugate
- Used for synthesizing dCBP-1
- Potent and selective heterobifunctional degrader of p300/CBP
- Purity of 96.7%
- Appearance: yellow to green (solid-liquid mixture)
- Store at -20°C, protect from light
Medchemexpress LLC Thalidomide-1-Me,4-OH | 2244568-06-5 | >98.0% | 288.26 | C14H12N2O5 | 25 MG
Thalidomide-1-Me,4-OH is a thalidomide analogue with a 1-methyl and 4-hydroxyl substitution that functions as an E3 ubiquitin ligase ligand. It is used in biochemical research to recruit E3 ligases (Cereblon-related activity) for targeted protein degradation studies.
- Acts as an E3 ligase ligand suitable for cereblon-mediated recruitment.
- Contains 1-methyl and 4-hydroxyl substitutions on the thalidomide scaffold.
- Molecular formula C14H12N2O5, molecular weight 288.26.
- Purity greater than 98%.
- Recommended storage: powder at -20°C (long-term) or 4°C (short-term); in solvent at -80°C for extended storage.
- Supplied in small research quantities, e.g., 25 MG, for biochemical assays.
Medchemexpress LLC Thalidomide-NH-PEG3-NH-Boc | 2204246-03-5 | 97.2% | 548.59 | 100 MG
Thalidomide-NH-PEG3-NH-Boc is a chemical compound with a molecular weight of 548.59. It appears as a light yellow to yellow oil and its structure is consistent with LCMS analysis. This product has been tested and complies with the given specifications.
- Molecular formula: C26H36N4O9
- Storage in pure form: -20°C for 3 years; 4°C for 2 years
- Storage in solvent: -80°C for 6 months; -20°C for 1 month
- Purity: 97.20%
- Appearance: Light yellow to yellow (oil)
Medchemexpress LLC Thalidomide-5-O-C9-NH2 hydrochloride | 451.94 | 5 MG
Thalidomide-5-O-C9-NH2 hydrochloride is a chemical compound primarily used as a laboratory chemical for research purposes and substance manufacturing. It is presented as a solid and is stable under recommended storage conditions.
- Solid appearance
- Stable under recommended storage conditions
- For research use only
Medchemexpress LLC Thalidomide-5-NH2-C8-NH2 TFA | 2097509-49-2 | >98.3% | 514.49 | 50 MG
Thalidomide-5-NH2-C8-NH2 TFA is a chemical compound suitable for synthesis applications.
- Used for compound synthesis
- Targeted as biochemical assay reagents
- Molecular formula: C23H29F3N4O6
Medchemexpress LLC Thalidomide-5-O-C6-NH2 hydrochloride | 2761398-05-2 | 409.86 | 5 MG
Thalidomide-5-O-C6-NH2 hydrochloride is a cereblon ligand based on Thalidomide. It is utilized in the recruitment of CRBN protein and can be linked to a ligand for protein via a linker to form PROTACs. It is a solid with a white to off-white appearance.
- Cereblon ligand
- Utilized in CRBN protein recruitment
- Can form PROTACs when linked to a protein ligand
- Available as a white to off-white solid
- Shipped at room temperature
- Stored at -20°C, protected from light and under nitrogen
Medchemexpress LLC Thalidomide-4-O-C14-NH2 hydrochloride | 99.9% | 522.08 | 5 MG
Thalidomide-4-O-C14-NH2 hydrochloride is a cereblon ligand derived from Thalidomide and is utilized for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to create PROTACs, which are relevant for research purposes.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Can be connected to a protein ligand by a linker to form PROTACs
- For research use only