Lactams
Selleck Chemical LLC Thalidomide-NH-C4-NH-Boc
Thalidomide-NH-C4-NH-Boc is a novel potent and selective class of Bromodomain-containing protein 4 (BRD4) and Bromodomain-containing protein 2 (BRD2) degrader for the development of therapeutics to treat cancers
Medchemexpress LLC N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g·mol⁻¹ | C21H23F3N4O8 | 2 G
Thalidomide-O-amido-C4-NH2 TFA is a thalidomide-derived cereblon ligand-linker conjugate provided as the trifluoroacetate (TFA) salt for use in PROTAC design and other chemical biology applications. It is supplied as a white to off-white solid with high analytical purity and a molecular weight of 516.42 g·mol⁻¹.
- Thalidomide-derived cereblon ligand-linker conjugate.
- Provided as the trifluoroacetate (TFA) salt.
- High purity by LCMS (reported 99.92%).
- White to off-white solid appearance.
- Molecular formula C21H23F3N4O8; molecular weight 516.42 g·mol⁻¹.
- Intended for research use only; not for human or diagnostic use.
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g/mol | C13H8F2N2O4 | 250 MG
Thalidomide-4,5-F is a fluorinated thalidomide analogue used as a cereblon (CRBN) ligand and E3 ligase recruiter for chemical biology and PROTAC research. It promotes ubiquitinylation of target proteins and can be derivatized at fluorine positions. Supplied as a solid powder with high purity and recommended cold storage conditions.
- Fluorinated analogue designed for cereblon engagement.
- High purity suitable for research applications.
- Available in multiple milligram-scale pack sizes.
- Stable solid form with defined cold storage conditions.
- Modifiable at fluorine positions for derivatization.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | >98.0% | 290.25 | C14H11FN2O4 | 500 MG
5-Fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione is a fluorinated thalidomide analogue described as an E3 ligase activator for research use. Supplied as a powder, it can serve as a synthetic building block for further derivatization, particularly by nucleophilic aromatic substitution (SNAr).
- Fluorinated thalidomide analogue useful for E3 ligase activation studies.
- Suitable as a synthetic building block for derivatization via SNAr.
- Supplied as a powder suitable for laboratory handling and storage.
- High purity; commonly listed as >98.0%.
- Typical pack sizes: 100 mg-1 g.
Medchemexpress LLC Tazobactam-15N3 sodium | 89785-84-2 | MFCD00917472 | 98.8% | 325.25 g/mol | C10H11(15N)3NaO5S | 1 MG
Tazobactam-15N3 sodium is the 15N-labeled isotopologue of tazobactam sodium intended for use as an analytical tracer or internal standard in quantitative NMR, GC-MS, and LC-MS methods. It is supplied as a sodium salt in small package sizes and is characterized by high chemical purity and supporting documentation.
- 15N-labeled isotopologue suitable as tracer or internal standard.
- High purity of 98.8% for reliable analytical results.
- Supplied in small quantities suitable for method development and standards (e.g., 1 mg).
- Certificate of analysis and safety data sheet available.
- Molecular weight 325.25 g/mol and chemical formula C10H11(15N)3NaO5S provided for documentation.
Medchemexpress LLC Thalidomide-5-NH-C-alkyne | 2357110-24-6 | MFCD34563706 | >98.0% | 311.29 g/mol | C16H13N3O4 | 100 MG
Thalidomide-5-NH-C-alkyne is an E3 ligase ligand-linker conjugate bearing a terminal alkyne for click-style conjugation, supplied for research use in small packs for assembling PROTACs and other bioconjugates.
- Contains a terminal alkyne for click conjugation.
- Functions as an E3 ligase ligand suitable for PROTAC assembly.
- Purity >98.0%.
- Molecular formula C16H13N3O4; molecular weight 311.29 g/mol.
- CAS number 2357110-24-6 for substance identification.
- Supplied as a 100 mg research pack.
- For research use only; not for human or animal therapeutic use.
Medchemexpress LLC 2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione | 2222115-19-5 | >98.0% | 294.21 g/mol | C13H8F2N2O4 | 1 G
Thalidomide-4,5-F is a fluorinated analogue of thalidomide used as a cereblon (CRBN) E3 ligase ligand in research. It promotes ubiquitinylation of target proteins and can be derivatized via substitution at the fluorine positions. Supplied as a powder with high reported purity for use in chemical biology and medicinal chemistry studies.
- Fluorinated thalidomide analogue enabling derivatization via fluorine substitution
- Acts as a cereblon (CRBN) E3 ligase ligand for targeted protein ubiquitination
- Promotes ubiquitinylation of proteins in biochemical assays
- High reported purity (≥98.0%) suitable for research use
- Powder form compatible with synthetic and analytical workflows
- Molecular formula C13H8F2N2O4 and molecular weight 294.21 g/mol
Medchemexpress LLC Thalidomide-o-amido-C3-COOH | 2308035-51-8 | 98.4% | 417.37 | C19H19N3O8 | 2 G
Thalidomide-O-amido-C3-COOH is an E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a short C3 linker terminating in a carboxylic acid. It is intended for use as a CRBN-recruiting building block in PROTAC synthesis and related targeted protein degradation research.
- used as a cereblon (CRBN) recruiting building block in PROTAC synthesis
- terminates in a carboxylic acid for conjugation to target ligands
- reported purity 98.43% by LCMS
- molecular weight 417.37; formula C19H19N3O8
- storage: 4°C under nitrogen; in solution store at -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC CD3 epsilon 1-27 pep 20ug | 20ug
CD3 epsilon is an important component of the TCR-CD3 complex on T lymphocytes and promotes TCR-mediated signaling When APC activates the TCR CD3 epsilon together with CD3D CD3G and CD3Z transmits signals across the cell membrane through ITAMs CD3 epsilon 1-27 peptide Protein Human (Biotinylated HEK293 hFc-Avi) is the recombinant human-derived CD3 epsilon 1-27 peptide protein expressed by HEK293 with C-Avi C-hFc labeled tag
Medchemexpress LLC HY-126457 5mg Medchemexpress, Thalidomide-propargyl CAS:2098487-39-7 Purity:>98%
Medchemexpress, HY-126457 5mg Thalidomide-propargyl CAS:2098487-39-7 Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.