Lactams
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | 25 MG
Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker. This compound is suitable for designing PROTAC CDK2/9 Degrader-1.
- Incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker
- Targets cereblon
- Has a molecular weight of 416.38
- Has a molecular formula of C19H20N4O7
- Appears as a solid with a light yellow to yellow color
- Purity of 98.45%
- Soluble in DMSO at 100 mg/mL (requires ultrasonic)
- Powder storage: -20°C for 3 years
- In-solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Thalidomide-5-O-C11-NH2 hydrochloride | >98.0% | 480.00 | C24H34ClN3O5 | 10 MG
Thalidomide-5-O-C11-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand used to recruit the CRBN E3 ligase in targeted protein degradation constructs. Supplied as a white to off-white solid, it is intended for research use in PROTAC synthesis and ligand-linker conjugation. Handle under light protection and low-temperature storage to maintain stability.
- Thalidomide-derived cereblon ligand for E3 ligase recruitment.
- High purity (>98.0% HPLC) suitable for synthetic applications.
- White to off-white solid, convenient for handling and weighing.
- Stable under low-temperature, light-protected storage when handled under nitrogen.
- Available in small research quantities for conjugation and PROTAC development.
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 50mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | 100 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research purposes only.
- Incorporates a thalidomide-based cereblon ligand
- Designed for use in PROTAC technology
- Targets cereblon
- Appears as a white to yellow solid
- Useful in cancer research applications
- Functions as an E3 ligase ligand-linker conjugate
- Involved in autophagy and apoptosis studies
- Acts as an inhibitor
Medchemexpress LLC Thalidomide-4-O-C5-NH2 hydrochloride | 2419145-66-5 | 96.9% | 395.84 | 25 MG
Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They are utilized to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Utilizes PROTAC technology for selective degradation of target proteins
- Exploits the intracellular ubiquitin-proteasome system
Medchemexpress LLC Thalidomide-5-PEG4-NH2 hydrochloride | 2743434-24-2 | 95.2% | 485.92 | 50 MG
Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker, and is used in PROTAC technology. This product is intended for research use only and is not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Utilizes a linker for PROTAC technology
- For research use only
Medchemexpress LLC Thalidomide-pyrrolidine (hydrochloride) | 2616553-35-4 | 98.0% | 335.74 g/mol | C15H14ClN3O4 | 10 MG
Thalidomide-pyrrolidine hydrochloride is a thalidomide-derived E3 ligase ligand supplied for laboratory research. It serves as a building block for the synthesis of proteolysis targeting chimeras (PROTACs) and related chemical probes. The compound is provided as a solid hydrochloride salt intended for research use only.
- E3 ligase ligand suitable for PROTAC synthesis.
- Hydrochloride salt form for improved stability and handling.
- Off-white to gray solid for solid-phase handling.
- High purity appropriate for research applications.
- Supplied in small pack sizes for synthesis and screening.
Sigma Aldrich Fine Chemicals Biosciences (+)-Thalidomide >=98% (HPLC), powder | 2614-06-4 | MFCD00210220 | 10MG
(+)-Thalidomide >=98% (HPLC), powder | Purity: >=98% (HPLC) | Mol Wt: 258.23 | 2614-06-4 | MFCD00210220 | 10MG
![Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261970.png-250.jpg)
Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG
Thalidomide-O-C6-COOH is a thalidomide-based cereblon (CRBN) E3 ligase ligand-linker conjugate terminating in a six-carbon carboxylic acid. It is used as a building block in PROTAC synthesis and chemical biology research, providing a convenient carboxylic acid handle for linker attachment and efficient recruitment of CRBN.
- Used in PROTAC design to recruit cereblon (CRBN) E3 ligase.
- Thalidomide-based ligand with a six-carbon carboxylic acid linker.
- High purity, 99.3% (reported).
- Soluble ≥100 mg/mL in DMSO.
- Off-white to light yellow solid suitable for synthesis.
- Molecular formula C20H22N2O7; molecular weight 402.40 g·mol⁻1.
- Storage recommendations provided for powder and solutions to maintain stability.
![eMolecules 921755-46-6 | (1R,2R,4R)-rel-1-Azabicyclo[2,2,1]heptane-2-carboxylic acid hydrochloride | Synthonix - Stock355.260 | C14H24Cl2N2O4 | 95.000 | Cl.Cl.OC(=O)[C@H]1C[C@H]2CC[N@@]1C2.OC(=O)[C@@H]1C[C@@H]2CC[N@]1C2 | 1g | 499991381](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502168053.JPG-250.jpg)
eMolecules 921755-46-6 | (1R,2R,4R)-rel-1-Azabicyclo[2,2,1]heptane-2-carboxylic acid hydrochloride | Synthonix - Stock355.260 | C14H24Cl2N2O4 | 95.000 | Cl.Cl.OC(=O)[C@H]1C[C@H]2CC[N@@]1C2.OC(=O)[C@@H]1C[C@@H]2CC[N@]1C2 | 1g | 499991381
(1R,2R,4R)-rel-1-Azabicyclo[2,2,1]heptane-2-carboxylic acid hydrochloride | Synthonix - Stock | 921755-46-6355.260 | C14H24Cl2N2O4 | 95.000 | Cl.Cl.OC(=O)[C@H]1C[C@H]2CC[N@@]1C2.OC(=O)[C@@H]1C[C@@H]2CC[N@]1C2 | 1g | 499991381
Medchemexpress LLC Thalidomide-4-O-C7-NH2 hydrochloride | 00-00-0 | 99.8% | C20H26ClN3O5 | 10MG
Thalidomide-4-O-C7-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate provided as the hydrochloride salt for research use in PROTAC development and E3 ligase recruitment studies. It is supplied as a high-purity, well-characterized reagent suitable for biochemical assays, linker conjugation, and medicinal chemistry workflows.
- High purity (99.8%) suitable for research applications.
- Hydrochloride salt form for consistent handling and storage.
- Characterized molecular formula C20H26ClN3O5 and molecular weight 387.43 g/mol.
- Functions as a cereblon (CRBN) E3 ligase ligand for PROTAC design.
- Available in small, lab-scale quantities for screening and synthesis.
- Datasheet and certificate of analysis available from the supplier.
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 50 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Uses a linker in PROTAC technology
- Targets Cereblon
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Cayman Chemical -ThalIdomIde 1g
An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1, 10, and 100 UG/ml; increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro; enhances NK cell-mediated cytotoxicity in MM.1S multiple myeloma cells; reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis at 4 mg/animal; induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 UG/kg egg weight)