Lactams
Medchemexpress LLC Thalidomide-piperazine-PEG1-NH2 diTFA | 00-00-0 | 99.4% | C25H29F6N5O9 | 10MG
Thalidomide-Piperazine-PEG1-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-based cereblon ligand with a short PEG1/piperazine linker for PROTAC design. Intended for research use only, the compound is supplied as a solid (white to yellow) with characterized solubility and storage recommendations to support experimental workflows.
- High purity for research use (99.4%).
- Thalidomide-based cereblon ligand facilitates E3 ligase recruitment.
- Short PEG1/piperazine linker suitable for PROTAC assembly.
- DMSO solubility: 100 mg/mL; sonication recommended.
- In vivo formulation options reach ~2.5 mg/mL as suspended or clear solutions.
- Storage: sealed at 4°C; in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | C25H36ClN5O9 | 10MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a thalidomide-based cereblon (CRBN) ligand-linker conjugate intended as a building block for PROTAC synthesis. The molecule combines a thalidomide-derived CRBN recruiting moiety with an amino-terminated PEG4-C2 spacer to enable straightforward coupling to target ligands. It is supplied as the hydrochloride salt for improved handling and is for research use only.
- High HPLC purity (98.0%).
- Amino-terminated PEG4-C2 linker for facile conjugation.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- Supplied as a solid hydrochloride salt, light yellow to yellow.
- Available in small-scale quantities suitable for medicinal chemistry.
- Store sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Thalidomide-Piperazine 5-fluoride | 2222114-22-7 | >96.5% | 360.34 | 5 G
Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate. Its intended use is for research purposes, specifically in the field of PROTAC (Proteolysis Targeting Chimeras) technology. It incorporates a thalidomide-based cereblon ligand and a linker. This product is not for sale to patients.
- Appearance: Solid, light yellow to green yellow
- Solubility: Soluble in DMSO (5.83 mg/mL or 16.18 mM)
- Storage: 4°C, protect from light; in solvent: -80°C for 6 months, -20°C for 1 month (protect from light)
- Related research areas: Cancer, PROTAC, autophagy, apoptosis, E3 ligase ligand-linker conjugates
- Cereblon ligand: Incorporates a thalidomide-based cereblon ligand
- PROTAC technology: Utilizes a linker commonly used in PROTAC technology
Medchemexpress LLC Thalidomide-4-O-C7-NH2 hydrochloride | 99.8% | 423.89 g/mol | C20H26ClN3O5 | 5 MG
Thalidomide-4-O-C7-NH2 hydrochloride is a thalidomide-derived cereblon ligand-linker conjugate used as an E3 ligase ligand in PROTAC development and CRBN recruitment studies.
- High chemical purity: 99.8%.
- Hydrochloride salt form for improved stability and solubility.
- Molecular formula C20H26ClN3O5; molecular weight 423.89 g/mol.
- Optimized for use as an E3 ligase ligand in biochemical and cell-based assays.
- Supplied in small research quantities suitable for synthesis and assay development.
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2H-isoindol-2-yl) | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 | C13H11IN2O3 | 50 MG
Deoxy-thalidomide-5-iodine is an iodinated thalidomide analog intended for chemical biology and PROTAC applications; it functions as a cereblon-binding ligand for E3 ligase recruitment and is supplied with analytical data confirming identity and high purity.
- Iodinated thalidomide analog useful for PROTAC research.
- Binds cereblon to enable E3 ligase recruitment.
- High purity: 98.0% by NMR.
- Molecular weight 370.14; formula C13H11IN2O3.
- Appearance: blue to blue-green solid.
- Store protected from light at 4°C; in solvent keep at -80°C (6 months) or -20°C (1 month).
- Supplied in small research quantities (50 mg).
Medchemexpress LLC Thalidomide-O-PEG2-propargyl | 2098487-52-4 | 98.3% | 400.38 | 500 MG
Thalidomide-O-PEG2-propargyl, also known as E3 ligase Ligand-Linker Conjugates 32, is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a 2-unit PEG linker, making it suitable for PROTAC technology. This product also functions as a click chemistry reagent, containing an Alkyne group and capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
- Synthesized E3 ligase ligand-linker conjugate.
- Used in PROTAC technology.
- Click chemistry reagent with an alkyne group.
- Undergoes CuAAc with azide groups.
Medchemexpress LLC Thalidomide-propargyne-PEG2-COOH | 2797619-65-7 | 98.7% | 428.39 g/mol | C21H20N2O8 | 5 MG
Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a PEG2 linker terminating in a propargyl carboxylic acid. It is intended for PROTAC construction and click-chemistry applications, providing an alkyne handle for downstream conjugation.
- Contains terminal propargyl (alkyne) group for copper-catalyzed azide-alkyne cycloaddition.
- Incorporates a PEG2 linker to improve solubility and provide appropriate spacer length.
- Acts as a cereblon ligand to recruit CRBN for targeted protein degradation strategies.
- High purity suitable for research and synthetic applications.
- Available in small pack sizes for efficient use in medicinal chemistry workflows.
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 100 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only and not intended for sale to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Utilizes linker used in PROTAC technology
- For research use only