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Lactams

Organic heterocyclic compounds that contain a cyclic amide; amide groups consist of a carbonyl carbon atom linked by a single bond to a nitrogen atom and either a hydrogen or a carbon atom. These compounds are the nitrogen analogs of lactones.

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1

Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | 25 MG
SDP

Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker. This compound is suitable for designing PROTAC CDK2/9 Degrader-1.

  • Incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker
  • Targets cereblon
  • Has a molecular weight of 416.38
  • Has a molecular formula of C19H20N4O7
  • Appears as a solid with a light yellow to yellow color
  • Purity of 98.45%
  • Soluble in DMSO at 100 mg/mL (requires ultrasonic)
  • Powder storage: -20°C for 3 years
  • In-solvent storage: -80°C for 6 months, -20°C for 1 month

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2

Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | 416.38 g/mol | C19H20N4O7 | 5 MG
SDP

Thalidomide-C2-amido-C2-COOH is an E3 ligase ligand-linker conjugate that incorporates a cereblon-binding thalidomide-derived moiety and a carboxylic acid linker. It is intended for use as a research reagent in PROTAC design and related chemical biology studies; not for human or clinical use.

  • CAS number: 2353496-84-9.
  • Molecular formula: C19H20N4O7.
  • Molecular weight: 416.38 g/mol.
  • Purity: 98.45% (typical by supplier).
  • Solubility: DMSO up to 100 mg/mL (may require sonication).
  • Storage: powder at -20°C; stock solutions at -80°C for long term.
  • Intended use: CRBN ligand for PROTAC design and E3 ligase studies.
  • Available in small mg quantities for research use.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Thalidomide 4-fluoride (Cereblon ligand 4) | 835616-60-9 | 99.83% | 276.22 | 25 G
SDP

Thalidomide 4-fluoride (Cereblon ligand 4) is a Thalidomide-based Cereblon ligand that is utilized in the recruitment of the CRBN protein. It can be linked to the ligand for IRAK4 protein via a linker to form PROTAC IRAK4 degrader-1. It is for research use only and not sold to patients.

  • Purity: 99.83%
  • Molecular weight: 276.22
  • Formula: C13H9FN2O4
  • CAS No.: 835616-60-9
  • Appearance: Solid
  • Color: Off-white to gray
  • Solubility (in vitro): DMSO : 200 mg/mL (724.05 mM; requires ultrasonic; hygroscopic DMSO impacts solubility, use newly opened DMSO)
  • Storage (powder): -20°C for 3 years, 4°C for 2 years
  • Storage (in solvent): -80°C for 2 years, -20°C for 1 year

ENCOMPASS_PREFERRED