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Lactams

Organic heterocyclic compounds that contain a cyclic amide; amide groups consist of a carbonyl carbon atom linked by a single bond to a nitrogen atom and either a hydrogen or a carbon atom. These compounds are the nitrogen analogs of lactones.

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Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | MFCD34368531 | ≥95.0% | 433.41 g/mol | C20H23N3O8 | 5 MG
SDP

Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon (CRBN) ligand with a short PEG2 carboxylic acid linker. It is designed as a building block for PROTAC (proteolysis targeting chimera) synthesis and related chemical biology research. For research use only.

  • Provides CRBN engagement via a thalidomide-derived ligand.
  • Contains a PEG2 spacer terminating in a carboxylic acid for linker conjugation.
  • Suitable as a building block for PROTAC synthesis and E3 ligase recruitment studies.
  • Characterized by analytical data, including HPLC, LC-MS, and NMR files.
  • Available in small research-scale quantities for medicinal chemistry applications.

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2

Medchemexpress LLC Thalidomide-4-O-C10-COOH | 2379870-45-6 | MFCD03424822 | 99.1% | 458.50 g·mol⁻¹ | C24H30N2O7 | 5 MG
SDP

Thalidomide-4-O-C10-COOH is an E3 ligase ligand-linker conjugate intended as a building block for PROTAC synthesis. It features a thalidomide-derived cereblon-recruiting motif linked via a C10 spacer to a terminal carboxylic acid, allowing standard coupling chemistry for attachment to target-binding ligands. Supplied as a high-purity solid for laboratory research use.

  • High purity suitable for synthesis work.
  • Carboxylic acid terminus for standard coupling reactions.
  • Contains a C10 spacer to provide linker flexibility.
  • Molecular formula: C24H30N2O7; molecular weight: 458.50 g·mol⁻¹.
  • Supplied in small mg-scale quantities appropriate for research.

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3

Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.3% | 440.95 | 5 MG
SDP

DDL-357 is a potent enhancer of secreted clusterin. It has been shown to reduce phospho-tau levels in the brain and improve memory in the murine 3xTg-AD model. It is intended for research use only and not for sale to patients.

  • Purity: 98.31%
  • Appearance: Solid
  • Color: White to off-white
  • Shipping: Room temperature in continental US; may vary elsewhere.
  • Storage (powder): -20°C for 3 years, 4°C for 2 years.
  • Storage (in solvent): -80°C for 6 months, -20°C for 1 month.
  • Solubility (in vitro): 100 mg/mL in DMSO (226.78 mM; requires ultrasonic, hygroscopic DMSO affects solubility).
  • Solubility (in vivo - protocol 1): ≥ 5 mg/mL (11.34 mM) in a mixture of 10% DMSO, 40% PEG300, 5% Tween-80, and 45% Saline, yielding a clear solution.

ENCOMPASS_PREFERRED