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Lactams

Organic heterocyclic compounds that contain a cyclic amide; amide groups consist of a carbonyl carbon atom linked by a single bond to a nitrogen atom and either a hydrogen or a carbon atom. These compounds are the nitrogen analogs of lactones.

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1

Medchemexpress LLC 2-(2,6-dioxopiperidin-3-yl)-5-methylisoindoline-1,3-dione | 40313-92-6 | MFCD30290642 | 99.9% | C14H12N2O4 | 10MG
SDP

Thalidomide-5-methyl is a thalidomide-derived ligand that recruits the cereblon (CRBN) E3 ubiquitin ligase and is used as a recruiting moiety in proteolysis-targeting chimera (PROTAC) synthesis and CRBN-focused chemical biology research.

  • Binds cereblon (CRBN) E3 ubiquitin ligase.
  • Suitable as a recruiting moiety in PROTAC synthesis.
  • High purity (99.9%).
  • Molecular formula C14H12N2O4, molecular weight 272.26.
  • Provided as a small-molecule solid, common pack size 10 mg.
  • Compatible with linker conjugation for medicinal chemistry applications.

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2

Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- | 40313-92-6 | 99.9% | 272.26 | 25 MG
SDP

Thalidomide-5-methyl is a cereblon (CRBN) ligand derived from Thalidomide, used for recruiting CRBN protein. It can be utilized in the synthesis of PROTACs.

  • Thalidomide-based cereblon (CRBN) ligand.
  • Used in the recruitment of CRBN protein.
  • Can be used to synthesize PROTACs.

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3

Medchemexpress LLC 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | 26166-92-7 | MFCD30188073 | 98.4% | 337.13 | C13H9BrN2O4 | 100 MG
SDP

Thalidomide-5-Br is a brominated thalidomide derivative supplied for research use in studies of inflammation, tumor biology, and neurology. It is provided as a solid research reagent; consult lot-specific documentation for analytical details.

  • Contains a bromodomain; used as a tool compound in biochemical and pharmacological research.
  • Reported purity approximately 98% (see product documentation for lot-specific certificate of analysis).
  • Solid, off-white to gray appearance suitable for analytical and synthetic applications.
  • Storage recommendations: room temperature for shipping; in solution store at -80°C (2 years) or -20°C (1 year).
  • Available in multiple pack sizes including 100 mg.

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4

Medchemexpress LLC 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | 26166-92-7 | MFCD30188073 | 97.0% | 337.13 | C13H9BrN2O4 | 25 MG
SDP

Thalidomide-5-Br (5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) is a brominated thalidomide derivative supplied as a research reagent and used in studies of inflammation, tumor biology, and neurology.

  • contains a brominated thalidomide core
  • used in inflammation research
  • applicable to tumor biology studies
  • suitable for neurology research
  • available in small research quantities

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