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Lactims

Organic heterocyclic compounds that consist of a cyclic carboximidic acid characterized by a carbon-nitrogen double bond within the ring; they are tautomeric with the lactams.

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1

Medchemexpress LLC 2-Pyrimidinamine, 4-[4-(1H-imidazol-1-yl)phenyl]-N-2-propyn-1-yl- | 2234272-10-5 | 98.1% | 25 MG
SDP

AP-C5 is a selective inhibitor of cGMP-dependent protein kinase II (cGKII) with a pIC50 of 7.2. It can be used for research on diarrheal disease and also functions as a click chemistry reagent containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.

  • Selective inhibitor of cGMP-dependent protein kinase II (cGKII)
  • pIC50 of 7.2 for cGKII
  • Useful for diarrheal disease research
  • Click chemistry reagent with an alkyne group
  • Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
  • Potentiates cAMP signaling by PDE inhibition
  • Partially blocks heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum

ENCOMPASS_PREFERRED
2

Medchemexpress LLC 2-Pyrimidinamine, 4-[4-(1H-imidazol-1-yl)phenyl]-N-2-propyn-1-yl- | 2234272-10-5 | 98.1% | 50 MG
SDP

AP-C5 is a selective inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2. It is used for the research of diarrheal disease. This compound is also a click chemistry reagent containing an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that contain Azide groups.

  • Potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation
  • Effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue
  • Potentiates cAMP signaling through PDE inhibition
  • Partially blocks heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum
  • Click chemistry reagent with an alkyne group
  • Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)

ENCOMPASS_PREFERRED
3

Medchemexpress LLC AP-C5 | 2234272-10-5 | 98.1% | 100 MG
SDP

AP-C5 selectively inhibits guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, making it suitable for diarrheal disease research. It is also a click chemistry reagent containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.

  • Inhibits cGMP-dependent cGKII-mediated protein phosphorylation.
  • Effectively inhibits cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue.
  • Potentiates cAMP signaling through PDE inhibition.
  • Partially blocks heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum.

ENCOMPASS_PREFERRED
4

Medchemexpress LLC 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine | 2234272-10-5 | 98.1% | C16H13N5 | 10MG
SDP

AP-C5 is a selective small-molecule inhibitor of cGMP-dependent protein kinase II (cGKII) used in cellular and biochemical research, including studies of diarrheal disease. It also contains an alkyne functional group that enables copper-catalyzed azide-alkyne cycloaddition (click chemistry) for probe conjugation.

  • Selective cGKII inhibition suitable for biochemical and cellular assays.
  • Click-chemistry compatible alkyne for facile probe conjugation.
  • High purity (>98%) for consistent experimental performance.
  • Solid, light yellow to light brown physical form for straightforward handling.
  • Stable when stored under recommended conditions for long-term use.
  • Good solubility in DMSO for preparation of screening solutions.

ENCOMPASS_PREFERRED
5

Medchemexpress LLC Pomalidomide-C5-azide | 2434629-02-2 | 97.5% | C18H20N6O4 | 10MG
SDP

Pomalidomide-C5-azide is an E3 ubiquitin ligase cereblon (CRBN) ligand-linker conjugate bearing a terminal azide for bioorthogonal click chemistry. It is used as a synthetic building block for PROTACs and related chemical biology probes, enabling attachment of linkers or payloads via azide-alkyne cycloaddition. Intended for research use only.

  • Terminal azide suitable for copper-catalyzed and strain-promoted click reactions.
  • Cereblon-binding ligand enables E3 ligase recruitment in degrader constructs.
  • Useful building block for PROTAC synthesis and chemical biology probe development.
  • High purity (≈97.5%) appropriate for research applications.
  • Solid, light yellow appearance; store cold, protected from light, under inert gas when possible.

ENCOMPASS_PREFERRED