Oxazinanes
Sigma Aldrich Fine Chemicals Biosciences Aprepitant >=98% (HPLC) | 170729-80-3 | MFCD12912491 | 25MG
Aprepitant >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 534.43 | 170729-80-3 | MFCD12912491 | 25MG
Sigma Aldrich Fine Chemicals Biosciences Aprepitant United States Pharmacopeia (USP) Reference Standard | 170729-80-3 | MFCD12912491 | 150MG
Aprepitant United States Pharmacopeia (USP) Reference Standard | Mol Wt: 534.43 | 170729-80-3 | MFCD12912491 | 150MG
Cayman Chemical SRT 1720 (hydrochloride), Purity: ≥98%, CAS: 1001645-58-4, 50 mg
A SIRT1 activator (EC1.5 = 0.16 µM in a cell-free fluorescence polarization assay); reduces acetylated p53 levels in U2OS cells at 0.1 µM; reduces fed blood glucose levels, improves insulin sensitivity, and increases mitochondrial capacity in a DIO mouse model of diabetes at 100 mg/kg; improves liver, adipose tissue, and skeletal muscle insulin sensitivity in Zucker fa/fa rats; decreases synovitis and delays osteoarthritis progression in mice at 25 mg/kg
Cayman Chemical HA-1077 (hydrochloride), Purity: ≥98%, CAS: 203911-27-7, 100 mg
A potent inhibitor of ROCK2, PRK-2, MSK1, and MAPKAP-K1b with IC50 values of 1.9, 4, 5, and 15 µM, respectively; has been shown to reduce blood vessel constriction, decreases pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in a diabetic rat model; drug forms are marketed for the treatment of pulmonary arterial hypertension and stable angina
Cayman Chemical Methyl-L-NIO (hydrochloride), Purity: ≥98%, CAS: 150403-96-6, 25 mg
A competitive NOS inhibitor; more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM)
Cayman Chemical SKF 96365 (hydrochloride), Purity: ≥98%, CAS: 130495-35-1, 1 mg
Inhibits the receptor-mediated influx of calcium via voltage-gated calcium channels (IC50 = 10 µM); inhibits the acetylcholine-induced depolarization of circular smooth muscle in a dose-dependent manner at 3-50 µM
Cayman Chemical FR122047 (hydrochloride), Purity: ≥98%, CAS: 130717-51-0, 10 mg
A selective COX-1 inhibitor (IC50 = 0.028 µM for the human enzyme); selective for COX-1 over COX-2 (IC50 = 65 µM); inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation in human platelet-rich plasma (IC50 = 180-200 nM); unlike aspirin, it does not induce gastric damage at 100 mg/kg, p.o.; has an anti-inflammatory effect in a rat models of collagen-induced arthritis
Cayman Chemical SB-242084 (hydrochloride), Purity: ≥98%, CAS: 1049747-87-6, 5 mg
An antagonist of the 5-HT2C receptor (pKi = 9.0), with at least 100-fold more selectivity over other 5-HT, dopamine, or adrenergic receptors; brain penetrant with significant anxiolytic activity; used extensively in animal research