Oxazinanes
Sigma Aldrich Fine Chemicals Biosciences TrizmaR hydrochloride reag25KG
Trizma(R) hydrochloride is mainly required for preparation of buffer at physiological range of 7.3 to 7.5. The prepared buffer is compatible with biological fluids. It is of importance to laboratories as a standard pH SOLUTIONon.
Cayman Chemical O-2545 (hydrochloride), Purity: ≥98%, CAS: 874745-43-4, 10 mg
A potent water-soluble agonist of CB1 and CB2 receptors with Ki values of 1.5 and 0.32 nM, respectively; when dissolved in saline, is highly efficacious in mouse behavioral models when administered either intravenously or intracerebroventricularly
Cayman Chemical SKF 96365 (hydrochloride), Purity: ≥98%, CAS: 130495-35-1, 10 mg
Inhibits the receptor-mediated influx of calcium via voltage-gated calcium channels (IC50 = 10 µM); inhibits the acetylcholine-induced depolarization of circular smooth muscle in a dose-dependent manner at 3-50 µM
Cayman Chemical HA-1077 (hydrochloride), Purity: ≥98%, CAS: 203911-27-7, 50 mg
A potent inhibitor of ROCK2, PRK-2, MSK1, and MAPKAP-K1b with IC50 values of 1.9, 4, 5, and 15 µM, respectively; has been shown to reduce blood vessel constriction, decreases pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in a diabetic rat model; drug forms are marketed for the treatment of pulmonary arterial hypertension and stable angina
Cayman Chemical CP 24,879 (hydrochloride), Purity: ≥98%, CAS: 10141-51-2, 1 mg
A Δ5/Δ6 desaturase inhibitor; reduces liver arachidonate content by ~50% in mice at 3 mg/kg; increases mead acid content and inhibits leukotriene C4 synthesis in murine mastocytoma cells at 5 µM
Cayman Chemical Methyl-L-NIO (hydrochloride), Purity: ≥98%, CAS: 150403-96-6, 50 mg
A competitive NOS inhibitor; more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM)