Oxazinanes
TARGETMOL CHEMICALS INC SKF-96365 HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SKF-96365 hydrochloride (SKF96365) a SOCE inhibitor exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically SKF-96365 hydrochloride treatment inhibited the calcium/calmodulin-dependent protein kinase II(gamma) (CaMKII(gamma))/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKII(gamma) or AKT abolished the effects of SKF-96365 on Y cells suggesting a critical role of the CaMKII(gamma)/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 hydrochloride inhibited hERG current in a concentration-dependent manner. purity: 99%
Medchemexpress LLC 5,6-Dihydro-5-methyluracil-d6 | 334473-42-6 | 1 MG
5,6-Dihydro-5-methyluracil-d6 is the deuterium-labeled version of 5,6-Dihydro-5-methyluracil (Dihydrothymine). Dihydrothymine is an intermediate breakdown product of thymine, found in animals and plants, and can be toxic at abnormally high levels. This compound is intended for research use only and is not sold to patients.
- Application as a tracer
- Internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS
- Deuterium substitution can influence the pharmacokinetic and metabolic profiles of drugs
- High purity (99%)
- Appearance: solid, white to off-white in color
- Molecular formula: C5H2D6N2O2
- Molecular weight: 134.17
Apexbio Technology LLC Prilocaine hydrochloride 1786-81-8 10mM (in 1mL DMSO)
Prilocaine hydrochloride (CAS 1786-81-8) is a local anesthetic belonging to the amino amide class It functions by reversibly inhibiting voltage-gated sodium channels on neuronal cell membranes thereby blocking the initiation and propagation of nerve impulses This property makes it suitable for investigating neuronal excitability pain signaling and ion channel pharmacology in various preclinical models Prilocaine hydrochloride is commonly employed in studies requiring local anesthesia and serves as a reference compound for benchmarking novel anesthetic agents in research settings
Cayman Chemical ClAmidine hydrochloride
A PAD inhibitor (IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively); cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 μM, respectively); reduces ex vivo extracellular NET formation and increases survival in a mouse model of CLP-induced sepsis at 50 mg/kg; decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies in a mouse model of collagen-induced arthritis
eMolecules 594-44-5 | Ethanesulfonyl chloride | Oakwood Chemical | MFCD00007460 | 128.570 | C2H5ClO2S | 99.000 | CCS(Cl)(=O)=O | 1g | 537693039
Ethanesulfonyl chloride | Oakwood Chemical | 594-44-5 | MFCD00007460 | 128.570 | C2H5ClO2S | 99.000 | CCS(Cl)(=O)=O | 1g | 537693039
Chemscene ChemScene | 4-(Morpholino)phenylboronic acid | 5G | CS-W009091 | 0.98 | 186498-02-2| MFCD03095169 | 207.038
ChemScene | 4-(Morpholino)phenylboronic acid | 5G | CS-W009091 | 0.98 | 186498-02-2| MFCD03095169 | 207.038