Oxazinanes
Medchemexpress LLC Quizartinib dihydrochloride | 1132827-21-4 | 99.8% | C29H34Cl2N6O4S | 25 MG
Quizartinib dihydrochloride (AC220 dihydrochloride) is the dihydrochloride salt form of Quizartinib. It is an orally active, highly selective, and potent second-generation type II FLT3 tyrosine kinase inhibitor. This compound inhibits wild-type FLT3 and FLT3-ITD autophosphorylation and induces apoptosis.
- Orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor
- Inhibits wild-type FLT3 and FLT3-ITD autophosphorylation
- Induces apoptosis
- Can be linked to the VHL ligand to form a PROTAC FLT3 degrader
Medchemexpress LLC Bersiporocin | 2241808-52-4 | 99.0% | C15H19Cl2N3O | 1 MG
Bersiporocin is a prolyl-tRNA synthetase inhibitor used in antifibrotic research. It exhibits an IC50 of ≤100 nM for phosphoribosylpyrophosphate synthetase (PRS) and is supplied as a white to off-white solid.
- Prolyl-tRNA synthetase inhibitor
- IC50 of ≤100 nM for phosphoribosylpyrophosphate synthetase (PRS)
- Suitable for antifibrotic research
- Ships at room temperature in continental US
- Store at 4°C, sealed, away from moisture and light
- For research use only
Medchemexpress LLC Tebanicline dihydrochloride | 209326-19-2 | 99.49% | C9H13Cl3N2O | 100 MG
Tebanicline dihydrochloride is an nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM. This compound shows preferential selectivity for neuronal nAChRs and acts as an agonist.
- Potent, orally effective analgesic activity.
- Inhibits binding of cytisine to α4β2 neuronal nAChRs.
- Selective for neuronal nAChRs.
- Agonist at transfected human α4β2 neuronal nAChR.
- Produces antinociceptive effects in models of acute and persistent pain.
- Effective against acute noxious thermal stimulation.
- Antinociceptive in rat models of acute thermal, persistent chemical, and neuropathic pain.
Medchemexpress LLC Tebanicline dihydrochloride | 209326-19-2 | 99.5% | C9H13Cl3N2O | 25 MG
Tebanicline dihydrochloride is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM. It is for research use only, and has shown antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain.
- Potent, orally effective analgesic activity
- Inhibits binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM
- Antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain
- Suitable for research use only
Medchemexpress LLC 1,11b-Dihydro-11b-hydroxymaackiain | 210537-05-6 | 302.28 | 1 MG
1,11b-Dihydro-11b-hydroxymaackiain is a pterocarpane extract from the stems of *Erycibe expansa*, which shows a hepatoprotective effect. It is for research use only, and not sold to patients.
- Hepatoprotective effect
- Purity: 97%
Medchemexpress LLC Febrifugine dihydrochloride | 32434-42-7 | 50 MG
Febrifugine dihydrochloride is a quinazolinone alkaloid with antimalarial and anticancer activity. It inhibits Plasmodium falciparum and also inhibits bladder cancer by hindering DNA synthesis, inducing apoptosis, and reducing steroids.
- Exhibits antimalarial activity against P. falciparum.
- Inhibits proliferation of bladder cancer cells.
- Suppresses DNA synthesis and induces cell death in cancer cells.
- Reduces steroidogenesis and promotes apoptosis.
- Significantly reduces mortality and parasitemia levels in infected mice.
- Effectively inhibits bladder cancer xenograft proliferation in vivo.
Medchemexpress LLC 5,6-Dihydro-5-methyluracil | 696-04-8 | 250 MG
5,6-Dihydro-5-methyluracil, also known as Dihydrothymine, is an intermediate breakdown product of thymine found in animals and plants. This substance is intended for laboratory use and research purposes only, and can be toxic at abnormally high levels.
- Intermediate breakdown product of thymine
- Found in animals and plants
- Can be toxic at abnormally high levels
- For research use only
- Appears as a white to off-white solid
- Stable under recommended storage conditions
Selleck Chemical LLC Tulobuterol hydrochloride
Tulobuterol is a long-acting 2-adrenergic receptor agonist that has bronchodilatory anti-inflammatory and antiviral activities
eMolecules Apollo Scientific 3 7-Dioxabicyclo[4 1 0]heptane 250mg 600856286 OR54673 95 000 286-22-6 MFCD11226853 100 117 C5H8O2
Apollo Scientific 3 7-Dioxabicyclo[4 1 0]heptane 250mg 600856286 OR54673 95 000 286-22-6 MFCD11226853 100 117 C5H8O2
Selleck Chemical LLC Iptacopan Hydrochloride
Iptacopan Hydrochloride is a first-in-class orally administered potent and highly selective factor B inhibitor with an IC50 of 12 nM and a Kd value of 7 9 nM Iptacopan exhibits excellent selectivity over other proteases affording IC50s of 30 M across a panel of 41 human proteases
Selleck Chemical LLC Filanesib hydrochloride
Filanesib (ARRY-520) hydrochloride is a kinesin spindle protein (KSP) inhibitor that blocks the separation of centrosomes and assembly of spindles in the early stage of cell mitosis and cell proliferation
Medchemexpress LLC m-PEG6-Br | 125562-29-0 | 99.8% | C13H27BrO6 | 250 MG
m-PEG6-Br is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins, by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Pure form storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
TARGETMOL CHEMICALS INC CSRM617 HYDROCHLORIDE 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 ( OC2 a master regulator of androgen receptor) with a K d of 7.43 uM in SPR assays directly binds to OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the mouse model of prostate cancer [1]purity: 99%
TARGETMOL CHEMICALS INC SB 258719 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5. purity: 98%
eMolecules Synthonix - Stock 2-(2 5-Dihydro-3-furanyl)-4 4 5 5-tetramethyl-1 3 2-dioxaborolane 250mg 525914654 D15488 0 000 212127-80-5 MFCD16996209 196 050 C10H17BO3
Synthonix - Stock 2-(2 5-Dihydro-3-furanyl)-4 4 5 5-tetramethyl-1 3 2-dioxaborolane 250mg 525914654 D15488 0 000 212127-80-5 MFCD16996209 196 050 C10H17BO3