Oxazinanes
Cayman Chemical SRT 1720 hydrochloride
A selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol; improves insulin sensitivity, lowers plasma, glucose and increases mitochondrial capacity in diet-induced obese and diabetic leptin-deficient ob/ob mice after one week of treatment with an oral dose of 100 mg/kg once daily.
Medchemexpress LLC N1,N1-dimethylpropane-1,2-diamine | 108-15-6 | MFCD00014812 | 99.3% | 102.18 | 500 MG
N1,N1-dimethylpropane-1,2-diamine is a laboratory chemical used in the manufacture of substances. It is intended for research use only and should be handled by experienced personnel. The product has not been fully validated for medical applications and is stable under recommended storage conditions.
- Laboratory chemicals
- Manufacture of substances
- Research use only
- Stable under recommended storage conditions
- Appearance: liquid, colorless to light yellow
Medchemexpress LLC Vacquinol-1 dihydrochloride (NSC13316 dihydrochloride) | 2309312-85-2 | 99.7% | 425.78 | 100 MG
Vacquinol-1 (NSC13316) dihydrochloride is a MKK4-specific activator that activates MAPK pathways. It specifically induces human glioblastoma cell (GC) death, attenuates tumor progression, and prolongs survival in a glioblastoma multiforme (GBM) mouse model. Vacquinol-1 dihydrochloride also induces apoptosis in hepatocellular carcinoma (HCC) cells.
- Activates MAPK pathways
- Induces human glioblastoma cell death
- Attenuates tumor progression
- Prolongs survival in a glioblastoma multiforme mouse model
- Induces apoptosis in hepatocellular carcinoma cells
Selleck Chemical LLC Alprenolol hydrochloride
Alprenolol hydrochloride is the hydrochloride salt form of alprenolol which is an beta adrenergic receptorantagonist and is used as an antihypertensive anti-anginal and anti-arrhythmic agent
Apexbio Technology LLC Pazopanib Hydrochloride 635702-64-6 10mM (in 1mL DMSO)
Pazopanib Hydrochloride (CAS 635702-64-6) is a small-molecule receptor tyrosine kinase inhibitor that targets multiple kinases involved in tumor growth and angiogenesis including VEGFR1 (IC50 10 nM) VEGFR2 (30 nM) VEGFR3 (47 nM) PDGFR (84 nM) FGFR (74 nM) c-Kit (140 nM) and C-FMS (146 nM) By inhibiting these receptors pazopanib suppresses both tumor proliferation and neovascularization Preclinical studies have demonstrated its antitumor activity in various human xenograft models such as renal prostate colon lung melanoma head and neck and breast cancers Pazopanib is employed in research focusing on tumor biology angiogenesis and targeted therapy development
TARGETMOL CHEMICALS INC SBE13 HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50 0.2 nM); no inhibition om Aurora A kinase Plk2/3. purity: 99%
Apexbio Technology LLC 7,8-dihydro-L-Biopterin 6779-87-9 5mg
7 8-dihydro-L-Biopterin (CAS 6779-87-9) is a reduced pterin and a biochemical precursor of tetrahydrobiopterin (BH4) a critical cofactor in the regulation of endothelial nitric oxide synthase (eNOS) BH4 is essential for nitric oxide (NO) synthesis and its oxidation or depletion alters NO-dependent signaling and increases oxidative stress a phenomenon observed in vascular cells under diabetic conditions 7 8-dihydro-L-Biopterin noncompetitively inhibits rat liver GTP cyclohydrolase I with a reported Ki of 14 4 M demonstrating approximately 12-fold higher potency compared to oxidized pterins This compound is valuable for elucidating redox regulation in eNOS signaling and for investigating pterin-mediated modulation of vascular oxidative responses
Cayman Chemical Trimidox hydrochloride
A specific ribonucleotide reductase inhibitor; inhibits growth of human promyelocytic leukemia HL-60 cells (IC50 = 35 µM)
TARGETMOL CHEMICALS INC Pivmecillinam hydrochloride
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Pivmecillinam hydrochloride (FL-1039 hydrochloride) is an orally active prodrug of mecillinam, an extended-spectrum penicillin antibiotic effective against gram-negative organisms, and is used as a substitute for amdinocillin. Purity 99.86%
TARGETMOL CHEMICALS INC TANDOSPIRONE CITRATE 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tandospirone citrate (SM-3997 citrate) is a potent and selective 5-HT1A receptor partial agonist (Ki 27 nM)purity: 99%
Selleck Chemical LLC Bobcat339 hydrochloride
Bobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 M and 73 M for TET1 and TET2 respectively Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe
eMolecules AA Blocks LLC 6-Bromo-3 4-dihydro-2h-isoquinolin-1-one 100mg 436020794 AA001EV3 0 000 147497-32-3 MFCD04114858 226 073 C9H8BrNO
AA Blocks LLC 6-Bromo-3 4-dihydro-2h-isoquinolin-1-one 100mg 436020794 AA001EV3 0 000 147497-32-3 MFCD04114858 226 073 C9H8BrNO
Medchemexpress LLC Elacestrant dihydrochloride | 1349723-93-8 | 99.5% | 531.56 | 1 ML
Elacestrant (RAD1901) dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant dihydrochloride also can inhibit growth of ER+ breast cancer cell lines in vitro and in vivo.
- Orally available and selective estrogen receptor degrader (SERD).
- Inhibits growth of ER+ breast cancer cell lines in vitro and in vivo.
- Demonstrates antitumor activity in breast cancer xenograft models.
- Induces complete tumor growth inhibition in mice.
- Tumor growth inhibition is maintained for 4 weeks after withdrawal.
AdipoGen Bupivacaine HCl monohydrate
Chemical. CAS 73360-54-0. Formula C18H28N2O . HCl . H2O. MW 288.4. 36.5 . 18.0. Synthetic. Bupivacaine is an amino amide local anesthetic that decreases current amplitude and inhibits whole cell K currents in Ca2-activated K channels and N-type voltage-gated KCNA and KCNC K channels. Bupivacaine also inhibits voltage-gated Na channels and tandem pore domain TASK-2/KCNK-5 K channels. The compound is cytotoxic at high concentrations inducing apoptosis and/or necrosis by interference with the mitochondrial energy transduction. Shown to inhibit aerobic ATP synthesis by i uncoupling of the oxidative phosphorylation OXPHOS and ii inhibition of the complex I of the respiratory. Other mechanisms include inhibition of the carnitine-acylcarnitine translocase or activation of the mitochondrial permeability transition pore MPTP.
Medchemexpress LLC 4-phenyl-7,8-dihydroxycoumarin | 842-01-3 | MFCD02058070 | 99.4% | 254.24 g·mol⁻¹ | C15H10O4 | 5 MG
4-phenyl-7,8-dihydroxycoumarin is a coumarin derivative provided for research use. It is used in bronchiectasis-related studies and supplied as an off-white to yellow solid or as a DMSO solution, with high purity and defined storage recommendations.
- High purity: 99.4%.
- Molecular formula: C15H10O4; molecular weight: 254.24 g·mol⁻¹.
- Physical form: off-white to yellow solid; also available as 10 mM solution in DMSO.
- Typical pack sizes: 5 mg, 10 mg, 50 mg, 100 mg.
- Storage: powder at -20°C (stable up to 3 years) or 4°C (up to 2 years); in solvent at -80°C (up to 6 months) or -20°C (up to 1 month).
- Intended use: for laboratory research only.