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Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist with poor penetration of the blood-brain barrier. It reduces gastric acid secretion and muscle spasm, and can be used in peptic ulcer research. Pirenzepine dihydrochloride also demonstrates anti-proliferative activity against cancer cells.
Reduces gastric acid secretion
Reduces muscle spasm
Used in peptic ulcer research
Shows anti-proliferative activity to cancer cells
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Also available in 5 mg 10 mg 25 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Dasotraline hydrochloride (SEP-225289 hydrochloride) (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine norepinephrine and serotonin transporters with IC50 values of 4 6 and 11 nM respectively. purity: 99%
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1 HDAC2 HDAC3 HDAC6 HDAC8 and HDAC10 are 4 nM 14 nM 11 nM 15 nM 7 nM and 20 nM respectively. CRA-026440 hydrochloride exhibits antitumor and antiangiogenic activities. purity: 99%
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Chemical. CAS 152-11-4. Formula C27H38N2O4 . HCl. MW 491.06. Synthetic Verapamil hydrochloride is an alpha-adrenergic receptor alpha-AR antagonist and calcium channel protein inhibitor that blocks the L-type Ca2 channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr P-glycoprotein. Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Chemical. CAS 152-11-4. Formula C27H38N2O4 . HCl. MW 491.06. Synthetic Verapamil hydrochloride is an alpha-adrenergic receptor alpha-AR antagonist and calcium channel protein inhibitor that blocks the L-type Ca2 channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr P-glycoprotein. Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Chemical. CAS 152-11-4. Formula C27H38N2O4 . HCl. MW 491.06. Synthetic Verapamil hydrochloride is an alpha-adrenergic receptor alpha-AR antagonist and calcium channel protein inhibitor that blocks the L-type Ca2 channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr P-glycoprotein. Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More