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Oxetanes

Organic heterocyclic compounds that consist of a four-membered ring with three carbon atoms and one oxygen atom.

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1

Medchemexpress LLC Taccalonolide A | 108885-68-3 | 5 MG
SDP

Taccalonolide A is a microtubule stabilizer, a steroid isolated from Tacca chantrieri. It exhibits cytotoxic and antimalarial activities, causing G2-M accumulation, Bcl-2 phosphorylation, and initiating apoptosis. It is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.

  • Functions as a microtubule stabilizer
  • Isolated from Tacca chantrieri
  • Exhibits cytotoxic and antimalarial properties
  • Causes G2-M accumulation and Bcl-2 phosphorylation
  • Initiates apoptosis
  • Effective against cell lines overexpressing P-glycoprotein (Pgp)
  • Effective against cell lines overexpressing multidrug resistance protein 7 (MRP7)

ENCOMPASS_PREFERRED
2

Medchemexpress LLC Typhaneoside | 104472-68-6 | 770.69 | 5 MG
SDP

Typhaneoside | 104472-68-6 | 770.69 | 5 MG

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Purfalcamine 5mg | 1038620-68-6 | 528.62 g/mol | C29H33FN8O | 5 MG
SDP

Purfalcamine is a research-grade small molecule inhibitor of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with reported antimalarial activity. It is intended for laboratory research use only and is used in biochemical and cellular assays to investigate parasite kinase function.

  • Selective inhibitor of PfCDPK1 for antimalarial research.
  • Reported purity of 99.44% suitable for in vitro assays.
  • Available as a solid (multiple sizes, including 5 mg) and as a 10 mM solution in DMSO.
  • Molecular weight 528.62 g/mol; molecular formula C29H33FN8O.
  • Provided for research use only; not for human or clinical applications.

ENCOMPASS_PREFERRED
4

Medchemexpress LLC (5Z)-4-methyl-2,6-dioxo-5-[(5-phenylfuran-2-yl)methylidene]pyridine-3-carbonitrile | 591239-68-8 | 99.3% | 10MG
SDP

(5Z)-4-methyl-2,6-dioxo-5-[(5-phenylfuran-2-yl)methylidene]pyridine-3-carbonitrile | 591239-68-8 | 99.3% | 10MG

ENCOMPASS_PREFERRED
5

Medchemexpress LLC 8-chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b,e]diazepine | 2369979-68-8 | 100.0% | 358.84 g/mol | C19H20ClFN4 | 5 MG
SDP

JHU37160 is a brain-penetrant DREADD agonist for chemogenetic research, showing potent activity at engineered muscarinic DREADDs and selective displacement of clozapine binding. It is provided as a solid (white to yellow) with reported high purity and recommended storage conditions for powder and solutions, suitable for in vitro and in vivo DREADD modulation studies.

  • Potent DREADD agonist with low-nanomolar EC50s (hM3Dq and hM4Di)
  • Brain-penetrant for in vivo applications
  • Selective displacement of [3H]clozapine from DREADDs
  • High reported purity suitable for research use
  • Supplied as a solid with specified storage conditions
  • Available in multiple small pack sizes and as a DMSO solution

ENCOMPASS_PREFERRED