Oxolanes
Medchemexpress LLC RK-582 | 2171388-28-4 | 98.05% | 510.60 | 50 MG
RK-582 is a tankyrase inhibitor, antitumor agent, and orally bioavailable growth inhibitor. It has an IC50 of 36.1 nM against human tankyrase-1 and 39.2 nM against human tankyrase-2. In APC-mutated colorectal cancer cells, sensitivity to RK-582 correlates with the level of active β-catenin, while drug resistance is associated with PIK3CA mutation. RK-582 can be used for the research of colorectal cancer.
- Tankyrase inhibitor
- Antitumor agent
- Orally bioavailable growth inhibitor
- IC50 of 36.1 nM against human tankyrase-1
- IC50 of 39.2 nM against human tankyrase-2
- Correlates with active β-catenin levels in APC-mutated colorectal cancer cells
- Useful for colorectal cancer research
eMolecules 1033194-54-5 | 4-(1-BENZYLPIPERIDIN-4-YLAMINO)-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID | AstaTech | MFCD11040503 | 358.460 | C18H22N4O2S | 95.000 | CSc1ncc(C(O)=O)c(NC2CCN(Cc3ccccc3)CC2)n1 | 1g | 112532178
4-(1-BENZYLPIPERIDIN-4-YLAMINO)-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID | AstaTech | 1033194-54-5 | MFCD11040503 | 358.460 | C18H22N4O2S | 95.000 | CSc1ncc(C(O)=O)c(NC2CCN(Cc3ccccc3)CC2)n1 | 1g | 112532178
Medchemexpress LLC KTX-582 | 2573298-13-0 | 98.7% | 872.93 | 5 MG
KTX-582 is a potent IRAK4 degrader that can induce apoptosis in MYD88MT DLBCL and is efficient in inducing in vivo tumor regressions in a lymphoma model. It degrades IRAK4 in whole blood monocytes and lymphocytes with high potency.
- Potent IRAK4 degrader with DC50 values of 4 nM for IRAK4 and 5 nM for Ikaros
- Induces apoptosis in MYD88MT DLBCL
- Efficient in inducing in vivo tumor regressions in a lymphoma model
- Degrades IRAK4 in whole blood monocytes and lymphocytes with IC50s of less than 0.05 μM
- Inhibits IRAK4 in human whole blood LPS TNFα with an IC50 of 0.05 to 1 μM
- Exhibits antiproliferative activity against human OCI-Ly10 cells (IC50: 14 nM)
BIOHIPPO Anti-HLA-A2-peptide (RLVDDFLLV) Complex (3A12), 100 µg
HLA-A2-peptide Complex (3A12) Recombinant Antibody (clone RLVDDFLLV) is a recombinant Mouse IgG1 antibody specific for HLA-A2-peptide Complex (3A12). It reacts with Human. Suitable for ELISA. Recombinant production ensures high specificity and lot-to-lot reproducibility. Supplied as 100 ug.